ID A0AMQ1_DROME Unreviewed; 391 AA.
AC A0AMQ1;
DT 28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=isocitrate dehydrogenase (NAD(+)) {ECO:0000256|ARBA:ARBA00013012};
DE EC=1.1.1.41 {ECO:0000256|ARBA:ARBA00013012};
DE AltName: Full=Isocitric dehydrogenase subunit alpha {ECO:0000256|ARBA:ARBA00042862};
DE AltName: Full=NAD(+)-specific ICDH subunit alpha {ECO:0000256|ARBA:ARBA00042642};
GN Name=CG3483 {ECO:0000313|EMBL:CAL25841.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:CAL25841.1};
RN [1] {ECO:0000313|EMBL:CAL25841.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ZBMEL384 {ECO:0000313|EMBL:CAL25841.1};
RX PubMed=16951084; DOI=10.1534/genetics.106.058008;
RA Proeschel M., Zhang Z., Parsch J.;
RT "Widespread adaptive evolution of Drosophila genes with sex-biased
RT expression.";
RL Genetics 174:893-900(2006).
RN [2] {ECO:0000313|EMBL:CAL25841.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ZBMEL384 {ECO:0000313|EMBL:CAL25841.1};
RA Proeschel M., Zhang Z., Parsch J.;
RT "Widespread adaptive evolution of Drosophila genes with sex-biased
RT expression.";
RL Genetics 0:0-0(0).
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AM293939; CAL25841.1; -; Genomic_DNA.
DR AlphaFoldDB; A0AMQ1; -.
DR VEuPathDB; VectorBase:FBgn0035005; -.
DR HOGENOM; CLU_031953_0_0_1; -.
DR ExpressionAtlas; A0AMQ1; baseline and differential.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR PANTHER; PTHR11835; DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE; 1.
DR PANTHER; PTHR11835:SF34; ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
PE 3: Inferred from homology;
KW Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532}.
FT DOMAIN 71..387
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
FT REGION 21..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..53
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 391 AA; 42888 MW; 9DBAE7C8D5BD313A CRC64;
MNTLRKLNSL PPFRSVGGAY RLFAGKDQKK DSAGQKTRQP EKPPQDKQKS KGASGKAKSA
GSTDSAKKTT KVTLINGEGV GRELMDAVQE VICAVKAPIE WDVHDEFKAK DSDDVSPEVL
QSLRANKVGI KGPVDSRHWQ RQIRKQFAQF AYVSLCSHIE GLDSPYGDFD VVIIRDQMEG
DYSGIEHLVV PGVMQTIKVS TTAGAARIAE FVFNYAVKNK RKRITVAHKA NIMRMTDGNF
LEAMRAEADK HVDDVLFEER YLDTCILKIL LKPHKCDVMV SSSMYGDVLR VIAGGMMGVP
GICPGYSVSS LGTVFDCRMK ACHALAGKDL ANPTGPLLSA ALMLRHVKMD KQADQVDCAI
RKVYKDTDIR TPDVGGKAKC SEFVKAVCDC L
//
