ID A0AN20_DROME Unreviewed; 323 AA.
AC A0AN20;
DT 28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=peptide chain release factor N(5)-glutamine methyltransferase {ECO:0000256|ARBA:ARBA00012771};
DE EC=2.1.1.297 {ECO:0000256|ARBA:ARBA00012771};
GN Name=CG9531 {ECO:0000313|EMBL:CAL25962.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:CAL25962.1};
RN [1] {ECO:0000313|EMBL:CAL25962.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ZBMEL377 {ECO:0000313|EMBL:CAL25962.1};
RX PubMed=16951084; DOI=10.1534/genetics.106.058008;
RA Proeschel M., Zhang Z., Parsch J.;
RT "Widespread adaptive evolution of Drosophila genes with sex-biased
RT expression.";
RL Genetics 174:893-900(2006).
RN [2] {ECO:0000313|EMBL:CAL25962.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ZBMEL377 {ECO:0000313|EMBL:CAL25962.1};
RA Proeschel M., Zhang Z., Parsch J.;
RT "Widespread adaptive evolution of Drosophila genes with sex-biased
RT expression.";
RL Genetics 0:0-0(0).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-
CC methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release
CC factor] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42896, Rhea:RHEA-
CC COMP:10271, Rhea:RHEA-COMP:10272, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30011, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:61891; EC=2.1.1.297;
CC Evidence={ECO:0000256|ARBA:ARBA00000932};
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DR EMBL; AM294058; CAL25962.1; -; Genomic_DNA.
DR AlphaFoldDB; A0AN20; -.
DR VEuPathDB; VectorBase:FBgn0031817; -.
DR HOGENOM; CLU_018398_4_1_1; -.
DR ExpressionAtlas; A0AN20; baseline and differential.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008276; F:protein methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR004556; HemK-like.
DR InterPro; IPR040758; PrmC_N.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR007848; Small_mtfrase_dom.
DR NCBIfam; TIGR00536; hemK_fam; 1.
DR PANTHER; PTHR18895; HEMK METHYLTRANSFERASE; 1.
DR PANTHER; PTHR18895:SF74; MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE; 1.
DR Pfam; PF05175; MTS; 1.
DR Pfam; PF17827; PrmC_N; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 41..108
FT /note="Release factor glutamine methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF17827"
FT DOMAIN 116..234
FT /note="Methyltransferase small"
FT /evidence="ECO:0000259|Pfam:PF05175"
SQ SEQUENCE 323 AA; 36727 MW; A3EAD1987A8A4C82 CRC64;
MLRQLTRSMG LTSRLLRQVN YGTNAPAGTH IPVTKALEIG QWEEKLKAAG VEDRKFNVKC
IVSHVLKQKF SSVPDSFDQL QLNPGQLADF ERFLEARCAR MPLQHIIGEW DFMDITLKTS
PSVFIPRPET EEFMRLVIDD HKNAKHVDLL EVGCGSGAMS LSMLHSLPQV VATAIERSKA
ATVLAAENAK MLGLLNRFEV HNHTMEEDKY LPDVLKDKKY DLIISNPPYV KTEEFQFLHP
EVVVYENLNA LDGGSDGLRV ARLVFDLACR HLRPGGKLWL ELGNDHPPMV KTIMNLKYEG
RLKFIAGYSD QYQRERFVQI EKV
//
