ID A0B576_METTP Unreviewed; 162 AA.
AC A0B576;
DT 28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=siroheme decarboxylase {ECO:0000256|ARBA:ARBA00023471};
DE EC=4.1.1.111 {ECO:0000256|ARBA:ARBA00023471};
GN OrderedLocusNames=Mthe_0047 {ECO:0000313|EMBL:ABK13850.1};
OS Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 /
OS PT) (Methanosaeta thermophila).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanotrichales; Methanotrichaceae; Methanothrix.
OX NCBI_TaxID=349307 {ECO:0000313|EMBL:ABK13850.1, ECO:0000313|Proteomes:UP000000674};
RN [1] {ECO:0000313|EMBL:ABK13850.1, ECO:0000313|Proteomes:UP000000674}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6194 / JCM 14653 / NBRC 101360 / PT
RC {ECO:0000313|Proteomes:UP000000674};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P.,
RA Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Kim E., Smith K.S., Ingram-Smith C., Richardson P.;
RT "Complete sequence of Methanosaeta thermophila PT.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+) + siroheme = 12,18-didecarboxysiroheme + 2 CO2;
CC Xref=Rhea:RHEA:19093, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:60052, ChEBI:CHEBI:140497; EC=4.1.1.111;
CC Evidence={ECO:0000256|ARBA:ARBA00023409};
CC -!- PATHWAY: Porphyrin-containing compound metabolism.
CC {ECO:0000256|ARBA:ARBA00023444}.
CC -!- SIMILARITY: Belongs to the Ahb/Nir family.
CC {ECO:0000256|ARBA:ARBA00023457}.
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DR EMBL; CP000477; ABK13850.1; -; Genomic_DNA.
DR AlphaFoldDB; A0B576; -.
DR STRING; 349307.Mthe_0047; -.
DR KEGG; mtp:Mthe_0047; -.
DR HOGENOM; CLU_112007_0_1_2; -.
DR Proteomes; UP000000674; Chromosome.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd00090; HTH_ARSR; 1.
DR Gene3D; 3.30.70.3460; -; 1.
DR InterPro; IPR011991; ArsR-like_HTH.
DR InterPro; IPR000485; AsnC-type_HTH_dom.
DR InterPro; IPR040523; AsnC_trans_reg2.
DR InterPro; IPR019888; Tscrpt_reg_AsnC-like.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR43413:SF1; SIROHEME DECARBOXYLASE NIRL SUBUNIT; 1.
DR PANTHER; PTHR43413; TRANSCRIPTIONAL REGULATOR, ASNC FAMILY; 1.
DR Pfam; PF17805; AsnC_trans_reg2; 1.
DR Pfam; PF13404; HTH_AsnC-type; 1.
DR SMART; SM00344; HTH_ASNC; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Reference proteome {ECO:0000313|Proteomes:UP000000674}.
FT DOMAIN 12..56
FT /note="HTH asnC-type"
FT /evidence="ECO:0000259|Pfam:PF13404"
FT DOMAIN 73..156
FT /note="Siroheme decarboxylase AsnC-like ligand binding"
FT /evidence="ECO:0000259|Pfam:PF17805"
SQ SEQUENCE 162 AA; 18521 MW; 96ABAA18420D51C3 CRC64;
MQEDASRMSQ EMDQTDLTLL RALQDGIPIV PHPFKEIGDR LGLDENTVIS RLRALRESGV
VRRFAATIGH RALGIIANAM IVWKVEDDIE RIGCIMASFE EVTHCYQRAT CDGWPYNLYT
VVHSRSREEC EEIASRISEA TGVKEYRILF SEKEYKKTSA RI
//