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Database: UniProt
Entry: A0CXP3_PARTE
LinkDB: A0CXP3_PARTE
Original site: A0CXP3_PARTE 
ID   A0CXP3_PARTE            Unreviewed;       857 AA.
AC   A0CXP3;
DT   28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2006, sequence version 1.
DT   07-JUN-2017, entry version 38.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=GSPATT00011192001 {ECO:0000313|EMBL:CAK75560.1};
OS   Paramecium tetraurelia.
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Peniculida; Parameciidae; Paramecium.
OX   NCBI_TaxID=5888 {ECO:0000313|EMBL:CAK75560.1, ECO:0000313|Proteomes:UP000000600};
RN   [1] {ECO:0000313|EMBL:CAK75560.1, ECO:0000313|Proteomes:UP000000600}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Stock d4-2 {ECO:0000313|EMBL:CAK75560.1,
RC   ECO:0000313|Proteomes:UP000000600};
RX   PubMed=17086204; DOI=10.1038/nature05230;
RG   Genoscope;
RA   Aury J.-M., Jaillon O., Duret L., Noel B., Jubin C., Porcel B.M.,
RA   Segurens B., Daubin V., Anthouard V., Aiach N., Arnaiz O., Billaut A.,
RA   Beisson J., Blanc I., Bouhouche K., Camara F., Duharcourt S.,
RA   Guigo R., Gogendeau D., Katinka M., Keller A.-M., Kissmehl R.,
RA   Klotz C., Koll F., Le Mouel A., Lepere G., Malinsky S., Nowacki M.,
RA   Nowak J.K., Plattner H., Poulain J., Ruiz F., Serrano V., Zagulski M.,
RA   Dessen P., Betermier M., Weissenbach J., Scarpelli C., Schaechter V.,
RA   Sperling L., Meyer E., Cohen J., Wincker P.;
RT   "Global trends of whole-genome duplications revealed by the ciliate
RT   Paramecium tetraurelia.";
RL   Nature 444:171-178(2006).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; CT868208; CAK75560.1; -; Genomic_DNA.
DR   RefSeq; XP_001442957.1; XM_001442920.1.
DR   STRING; 412030.XP_001442957.1; -.
DR   EnsemblProtists; CAK75560; CAK75560; GSPATT00011192001.
DR   GeneID; 5028742; -.
DR   KEGG; ptm:GSPATT00011192001; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   InParanoid; A0CXP3; -.
DR   KO; K02154; -.
DR   OMA; MFLQPEA; -.
DR   Proteomes; UP000000600; Partially assembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000600};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000600};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    426    455       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    475    494       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    559    582       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    588    612       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    660    679       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    790    810       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   857 AA;  99013 MW;  E916551DCD0813DF CRC64;
     MNFFRSQTMG YYKLIIPRES AWNVMNELAE LDCIHFVDYD PTLPMINRPF ANYIKRCDDL
     LVKLSLIEHE MKKYQKKITY CKDVNFLIKN FKQLIKERSK ASHTYLDEIE NDIDKKHQQL
     IEQSTNMENL HERRNKLIEH KSVLLKGEAL LGQSFFQPAN YVAEGYVNLQ GKELDDIKIL
     QGSVKFNYLV GVINKEDQIR FKRIIFRITK GNAWMNTMDI ESDQIVDTKN DDAKIIKSVF
     VVVYPGGGGS NVITNKLNKI CESFQVAKYT FPENNMVFQE KLRQIETELV ETRNVHILIY
     ILQLKPTLMI SKEFIKTPIV HKLEELKLFL VKEKYLYTQL NYLRVQGSVL YGSIWLPQGA
     DIKVDQALRE VQTNYEGLPT GQLQISPPEG TRPPPTYFET NEITWGFQEI VNTYGMPRYK
     EINPGLFTVM TFPFLFGVMF ADIGHGFCLL LLGIYLCVYN KEIKESDSLM KHALIVRHMV
     LMMGFWAFYN GWIYNDFMSV PINLFGSCYE PGTVDDPIHK DEQVWVQKDE SCVYPFGIDP
     VWMCVPNELT FMNSYKMKLA VIIGVIHMTF GIILKGINAI YFKNWIDFIF EFIPQIIFFT
     CTFGWMDFLI IYKWFVNWTG KTDQAPSVIT LMINMILAPA KTVDPPLWGD GQSEASTQTA
     MLLIALFCIP IILLPKPLIL NSQNKKHQAQ GPNGLADEKK ELYQKINEDS EGTQENSEIH
     TEQSGGGGHH EEFGDIFVHQ VIETIEFVLG SISNTASYLR LWALSLAHGQ LAEVFFQMCL
     NGGYSYAINF QLLIGYTIFS MATFGVLMMM DVMECFLHAL RLHWVEFQNK FFKADGYAFE
     KCSYAKVMQD NAVPKEE
//
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