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Database: UniProt
Entry: A0CZ03_PARTE
LinkDB: A0CZ03_PARTE
Original site: A0CZ03_PARTE 
ID   A0CZ03_PARTE            Unreviewed;       692 AA.
AC   A0CZ03;
DT   28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2006, sequence version 1.
DT   27-SEP-2017, entry version 73.
DE   RecName: Full=Phosphodiesterase {ECO:0000256|RuleBase:RU363067};
DE            EC=3.1.4.- {ECO:0000256|RuleBase:RU363067};
GN   ORFNames=GSPATT00011621001 {ECO:0000313|EMBL:CAK76020.1};
OS   Paramecium tetraurelia.
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Peniculida; Parameciidae; Paramecium.
OX   NCBI_TaxID=5888 {ECO:0000313|EMBL:CAK76020.1, ECO:0000313|Proteomes:UP000000600};
RN   [1] {ECO:0000313|EMBL:CAK76020.1, ECO:0000313|Proteomes:UP000000600}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Stock d4-2 {ECO:0000313|EMBL:CAK76020.1,
RC   ECO:0000313|Proteomes:UP000000600};
RX   PubMed=17086204; DOI=10.1038/nature05230;
RG   Genoscope;
RA   Aury J.-M., Jaillon O., Duret L., Noel B., Jubin C., Porcel B.M.,
RA   Segurens B., Daubin V., Anthouard V., Aiach N., Arnaiz O., Billaut A.,
RA   Beisson J., Blanc I., Bouhouche K., Camara F., Duharcourt S.,
RA   Guigo R., Gogendeau D., Katinka M., Keller A.-M., Kissmehl R.,
RA   Klotz C., Koll F., Le Mouel A., Lepere G., Malinsky S., Nowacki M.,
RA   Nowak J.K., Plattner H., Poulain J., Ruiz F., Serrano V., Zagulski M.,
RA   Dessen P., Betermier M., Weissenbach J., Scarpelli C., Schaechter V.,
RA   Sperling L., Meyer E., Cohen J., Wincker P.;
RT   "Global trends of whole-genome duplications revealed by the ciliate
RT   Paramecium tetraurelia.";
RL   Nature 444:171-178(2006).
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000256|RuleBase:RU363067};
CC       Note=Binds 2 divalent metal cations per subunit. Site 1 may
CC       preferentially bind zinc ions, while site 2 has a preference for
CC       magnesium and/or manganese ions. {ECO:0000256|RuleBase:RU363067};
CC   -!- SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase
CC       family. {ECO:0000256|RuleBase:RU363067,
CC       ECO:0000256|SAAS:SAAS00865541}.
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DR   EMBL; CT868219; CAK76020.1; -; Genomic_DNA.
DR   RefSeq; XP_001443417.1; XM_001443380.1.
DR   ProteinModelPortal; A0CZ03; -.
DR   STRING; 412030.XP_001443417.1; -.
DR   EnsemblProtists; CAK76020; CAK76020; GSPATT00011621001.
DR   GeneID; 5029202; -.
DR   KEGG; ptm:GSPATT00011621001; -.
DR   eggNOG; KOG3688; Eukaryota.
DR   eggNOG; ENOG410XQDD; LUCA.
DR   InParanoid; A0CZ03; -.
DR   KO; K01120; -.
DR   OMA; PGYNNVF; -.
DR   Proteomes; UP000000600; Partially assembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:InterPro.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 1.10.1300.10; -; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR023088; PDEase.
DR   InterPro; IPR002073; PDEase_catalytic_dom.
DR   InterPro; IPR023174; PDEase_CS.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF00233; PDEase_I; 1.
DR   PRINTS; PR00387; PDIESTERASE1.
DR   SMART; SM00471; HDc; 1.
DR   PROSITE; PS00126; PDEASE_I; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000600};
KW   Hydrolase {ECO:0000256|RuleBase:RU363067,
KW   ECO:0000256|SAAS:SAAS00865573}; Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|RuleBase:RU363067,
KW   ECO:0000256|SAAS:SAAS00865543};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000600};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    144    165       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    177    201       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    213    233       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      431    602       HDc. {ECO:0000259|SMART:SM00471}.
SQ   SEQUENCE   692 AA;  81131 MW;  4D507A7F3B940FC1 CRC64;
     MKYLRFLMLL NFDNINLHYY QQFRYLLYQK REENYKEIQY YGNQFEGFQS FSYIRFNLLI
     TKDYSQQQLI LLIVITYKQL QFNMLASRSD SQLRSLENPD KQTMRGESSK RSDKLLEIPR
     KKLNMRLYTE QEQKIQNLIN SKTVTISIIA LVGIYAILIF VIVALEELMD ETQFNNVSVI
     LSWIELGILI VFILEIAVGL YAWGVMKYYK DKWLILDTLI ILLSLFFVIF ELADQKTSNV
     VKVIQAVFRF LRIFLLIRKA QTFRRLSTMS TISTPAEKIV RFLSELKEVI ELESMKLDID
     YCIDKIGNNQ LYQMGKLDDD NAEAMGWLNQ SQQGKSSVRK IVTVEQQQQQ KKVLANFQRL
     NIPKRVLELL DKQHDDLYID PFECDKLSGG EGLVYLMLFL FENYNLYDVF LIKPKVVRSY
     FEEVMRGYQD NPYHNRVHAQ DVAQTCNFLL NRCKFIEIGQ LDEQDIACVL IAGAIHDYGH
     PGLTNAFLIN SKNELALTYN DQSVLEMFHP SQCFKIAWTN QKANIFESLT FQKYRRIRES
     IISMVLSTDM AHHASELAIT NSRVAAPDFE PYGKDKQRLM DLVVHSSDVS NPTKSFEIYK
     QWTERVLTEF WLQGDKEREL GLPISYLCNR YTTNMAEAQL GFIDYVVKPT FSCVQGFLPA
     FEPYLENLDK NKAKWQELVG YYKQQLASIQ TQ
//
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