ID A0D2J3_PARTE Unreviewed; 986 AA.
AC A0D2J3;
DT 28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Chromosome undetermined scaffold_35, whole genome shotgun sequence {ECO:0000313|EMBL:CAK77260.1};
GN ORFNames=GSPATT00012768001 {ECO:0000313|EMBL:CAK77260.1};
OS Paramecium tetraurelia.
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Peniculida; Parameciidae; Paramecium.
OX NCBI_TaxID=5888 {ECO:0000313|EMBL:CAK77260.1, ECO:0000313|Proteomes:UP000000600};
RN [1] {ECO:0000313|EMBL:CAK77260.1, ECO:0000313|Proteomes:UP000000600}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Stock d4-2 {ECO:0000313|EMBL:CAK77260.1,
RC ECO:0000313|Proteomes:UP000000600};
RX PubMed=17086204; DOI=10.1038/nature05230;
RG Genoscope;
RA Aury J.-M., Jaillon O., Duret L., Noel B., Jubin C., Porcel B.M.,
RA Segurens B., Daubin V., Anthouard V., Aiach N., Arnaiz O., Billaut A.,
RA Beisson J., Blanc I., Bouhouche K., Camara F., Duharcourt S., Guigo R.,
RA Gogendeau D., Katinka M., Keller A.-M., Kissmehl R., Klotz C., Koll F.,
RA Le Moue A., Lepere C., Malinsky S., Nowacki M., Nowak J.K., Plattner H.,
RA Poulain J., Ruiz F., Serrano V., Zagulski M., Dessen P., Betermier M.,
RA Weissenbach J., Scarpelli C., Schachter V., Sperling L., Meyer E.,
RA Cohen J., Wincker P.;
RT "Global trends of whole-genome duplications revealed by the ciliate
RT Paramecium tetraurelia.";
RL Nature 444:171-178(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CT868263; CAK77260.1; -; Genomic_DNA.
DR RefSeq; XP_001444657.1; XM_001444620.1.
DR AlphaFoldDB; A0D2J3; -.
DR STRING; 5888.A0D2J3; -.
DR EnsemblProtists; CAK77260; CAK77260; GSPATT00012768001.
DR GeneID; 5030441; -.
DR KEGG; ptm:GSPATT00012768001; -.
DR eggNOG; KOG1965; Eukaryota.
DR HOGENOM; CLU_005912_8_0_1; -.
DR InParanoid; A0D2J3; -.
DR Proteomes; UP000000600; Partially assembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015386; F:potassium:proton antiporter activity; IBA:GO_Central.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0051453; P:regulation of intracellular pH; IBA:GO_Central.
DR GO; GO:0098719; P:sodium ion import across plasma membrane; IBA:GO_Central.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 6.10.140.1330; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF86; SODIUM_HYDROGEN EXCHANGER 7; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000600};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 35..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 64..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 94..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 124..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 155..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 287..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 317..337
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 357..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..411
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 744..789
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 986 AA; 112559 MW; 8AA53E6B037935DA CRC64;
MAEHESEFEG HEEELEAPKD SLWRDEHEME KSANIVYFLT LGIVSGLILR EINKKTKLPY
SPMILSLGIL LGLLQKSLGY VGESASILSK MHPHLIVFVF VPVLLFESAF NCDWYTFKYQ
MVNILLLAGP GCGWGAILLG AIFKLVLQYD DNDMTWYQAF TLGSVLSATD PVAVVALLKE
LGASLAFNHL IEGEALLNDG VAMVFFIFFN KFSKAASGKG EAVTASQVVL NFVRNSLVGP
ALGLILGILA ALWTKRILGD DIEVTWLTFV FTYLTFYWAE FCFFKTSGLL AVVGLGLFWS
AFGKTRIRSS VEHSVHTVWG FVQYSCDTLI FLLVGIIVGT QVIEETFIHK SDYIRMIVFY
FFMILARFIM ILTFWPFLRC FGYPISKSEF IVLVYGGLRG ALGLTLSLMV GCDEELPARF
RHLSVFYGAG MAAITNLING TTCKALVQYL EMIENPVVKK KVYKKYLEEL IVNSQDKMRE
LESDQFYSMA DWNQIEKLET EIKYMLGSNK VQTSSSNLYE GLTDQEIFGE VRYRIYRILK
GLYYDKFEYG LCEEDTVRLL VESSDIGLDH TKAILNIWDQ LYKNFLNFSS VNFFFKVKEM
PLIGPFARDY MIKHLGFVYD VTTTFLSCAS EAFHLTGTFP MSKDAIRVVM EELNKEIEKA
EGYLGILNDT FPEIVRAIQT KRASHSILTH QRHYLDDTQQ NGLVDEKEYQ LLKKEINTRL
VDLENHQFDM VLPSFHVLAM EFPIFSGLVS TDLDNIIKSA YEKKFGPDEI IYEQGMTCQN
IYIVSKGNVV DEFAGGTIRK GLGTLITYTN LIGDGTCMST AKTTADSLLY SLNLKILKDL
MSKNPDFEFK IYINSLEYLR KMFENQAGPL ANVEIKRLLD FLRTKSKLKK FTTNQKCDFI
FGGYLFRGEL KDINNQVYSQ YTYIPPQDTE CLVTKDCQCL TFEDSVDSFN NQMLKQLDLD
PHKDQQIQER YSQIKRTSMM EKSKLN
//
