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Database: UniProt
Entry: A0DLV0_PARTE
LinkDB: A0DLV0_PARTE
Original site: A0DLV0_PARTE 
ID   A0DLV0_PARTE            Unreviewed;      1225 AA.
AC   A0DLV0;
DT   28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2006, sequence version 1.
DT   06-JUL-2016, entry version 67.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CAK84017.1};
GN   ORFNames=GSPATT00039649001 {ECO:0000313|EMBL:CAK84017.1};
OS   Paramecium tetraurelia.
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Peniculida; Parameciidae; Paramecium.
OX   NCBI_TaxID=5888 {ECO:0000313|EMBL:CAK84017.1, ECO:0000313|Proteomes:UP000000600};
RN   [1] {ECO:0000313|EMBL:CAK84017.1, ECO:0000313|Proteomes:UP000000600}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Stock d4-2 {ECO:0000313|EMBL:CAK84017.1,
RC   ECO:0000313|Proteomes:UP000000600};
RX   PubMed=17086204; DOI=10.1038/nature05230;
RG   Genoscope;
RA   Aury J.-M., Jaillon O., Duret L., Noel B., Jubin C., Porcel B.M.,
RA   Segurens B., Daubin V., Anthouard V., Aiach N., Arnaiz O., Billaut A.,
RA   Beisson J., Blanc I., Bouhouche K., Camara F., Duharcourt S.,
RA   Guigo R., Gogendeau D., Katinka M., Keller A.-M., Kissmehl R.,
RA   Klotz C., Koll F., Le Mouel A., Lepere G., Malinsky S., Nowacki M.,
RA   Nowak J.K., Plattner H., Poulain J., Ruiz F., Serrano V., Zagulski M.,
RA   Dessen P., Betermier M., Weissenbach J., Scarpelli C., Schaechter V.,
RA   Sperling L., Meyer E., Cohen J., Wincker P.;
RT   "Global trends of whole-genome duplications revealed by the ciliate
RT   Paramecium tetraurelia.";
RL   Nature 444:171-178(2006).
CC   -!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
CC       {ECO:0000256|SAAS:SAAS00595154}.
CC   -!- SIMILARITY: Contains PI3K/PI4K domain.
CC       {ECO:0000256|SAAS:SAAS00595215}.
CC   -!- SIMILARITY: Contains PIK helical domain.
CC       {ECO:0000256|SAAS:SAAS00026614}.
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DR   EMBL; CT868492; CAK84017.1; -; Genomic_DNA.
DR   RefSeq; XP_001451414.1; XM_001451377.1.
DR   STRING; 412030.XP_001451414.1; -.
DR   EnsemblProtists; CAK84017; CAK84017; GSPATT00039649001.
DR   GeneID; 5037199; -.
DR   KEGG; ptm:GSPATT00039649001; -.
DR   eggNOG; KOG0904; Eukaryota.
DR   eggNOG; COG5032; LUCA.
DR   InParanoid; A0DLV0; -.
DR   KO; K00922; -.
DR   Proteomes; UP000000600; Partially assembled WGS sequence.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
DR   GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro.
DR   Gene3D; 1.10.1070.11; -; 1.
DR   Gene3D; 1.25.40.70; -; 1.
DR   Gene3D; 2.60.40.150; -; 2.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   InterPro; IPR018936; PI3/4_kinase_CS.
DR   InterPro; IPR002420; PI3K_C2_dom.
DR   InterPro; IPR000341; PI3K_Ras-bd_dom.
DR   InterPro; IPR015433; PI_Kinase.
DR   InterPro; IPR001263; PInositide-3_kin_accessory_dom.
DR   InterPro; IPR029071; Ubiquitin-rel_dom.
DR   PANTHER; PTHR10048; PTHR10048; 5.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
DR   Pfam; PF00792; PI3K_C2; 1.
DR   Pfam; PF00794; PI3K_rbd; 1.
DR   Pfam; PF00613; PI3Ka; 1.
DR   SMART; SM00145; PI3Ka; 1.
DR   SMART; SM00146; PI3Kc; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF49562; SSF49562; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   SUPFAM; SSF56112; SSF56112; 2.
DR   PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR   PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR   PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR   PROSITE; PS51547; PI3K_C2; 1.
DR   PROSITE; PS51546; PI3K_RBD; 1.
DR   PROSITE; PS51545; PIK_HELICAL; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000600};
KW   Kinase {ECO:0000256|SAAS:SAAS00429360};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000600};
KW   Transferase {ECO:0000256|SAAS:SAAS00429315}.
FT   DOMAIN      119    224       PI3K-RBD. {ECO:0000259|PROSITE:PS51546}.
FT   DOMAIN      442    591       C2 PI3K-type. {ECO:0000259|PROSITE:
FT                                PS51547}.
FT   DOMAIN      647    826       PIK helical. {ECO:0000259|PROSITE:
FT                                PS51545}.
FT   DOMAIN      958   1225       PI3K/PI4K. {ECO:0000259|PROSITE:PS50290}.
SQ   SEQUENCE   1225 AA;  144337 MW;  AF53D4F2F51AA866 CRC64;
     MDRQLQTSQR IFTKAQVDEK VKYLLCVDMD SHQIFTINLK NHEICIEYEV PQVYRVKAKK
     DIMDIQKLVQ LPDSSWNMDT LRNQRYRRRE ISEYLLHKIV NQEPTYLAES SMSDAFSKVT
     SLKLIVDLSD YIRLEDQAYQ DINPITIELH VDLVTCSDEV IKKILRVVYN NFQVRLKTKS
     PENQFVLQIS GFREYLAGNY SILSYDRVRM NLRGIQYLQV NLTEVSKVRR MYDNFPPIFE
     RNADESVPWE QFMDIPCFLF YAPFPLRDIQ NEEGKKRKKI SRQDSNFSPL RPRLFLKERC
     LEFVEMRYQM LQERYFPLKK SIIYSGECDY RFKIQILCLS NVHRLFILDD KDLDEFKKQN
     GHKRRATYNG QCPPRFITKA SAKQEEQHNT SKKKVKVEDE EKLQKKISFL KLCKTKEQDA
     AQIKQLSKGT FNPHFFNHGP QGTANMECLM QKYELDIQPY LISVQVLLMY GQTPLTKFSI
     VNSQKVPFRQ NTWFYQDVSF QGLKISQLPM ELRLCFNIVL HSSNGEEQII GSTITELFDE
     NGKLKQGRLH LNVWPFYKCD TRIACMNEYY GAALPNQERT PYYTQLVIGM PTFIEDVYWS
     LRDEKYMKQV GFPSTPLNIQ QISLQYMNGI LERRGTLNSS VTVRPQRDWK ATPNTNELAK
     LDRLLKFDPL QRHLYTDEDK FILLKCRNHY KNQPSAFPIF LCAINWSDPE EIREVYQMMK
     VWTSLPSDDA LPLLDANISD ELVRYYATKR VGLYKDDELV LFMLELTQAL IFEQCHFSPL
     GEMLIERSIM NPWVVGHELF WQLRSQLHIQ PTYERYSLIL EQLMMLFGNY RYELFGEVQV
     NDEIMQIADF IKTEKDSGKR LKEMKNKLQD ARQKFSKTFQ FAIDPRMSAS ELIYEKCKIL
     DSKKLPLWLV MKSAETRDVT QIPKQIIMLS SKNLKDTDCL ENLRREKELR KITINDKFLI
     IFKCGDDIRQ DLLTLQLIKI MDKIWLDFGL DYRMKPYKVI STLDQVGMIE VVLNSDTTSS
     IHENAGKFGA LNKSSIMEYL KKHNKHSMEN AVENFLRSCA GYCVATYLLG IGDRHSGNIM
     LTESGHLFHI DFGHFLGNKL TIILGNFKTK YGINRERTPF VFTQEMAYVM GGVQGHNFQR
     FEDFCTKAYN QIRQHGHLLI NIFLMNLSAG MPELQEIADI EYLREKLQLD IGEQQATELF
     RKEITTSLND MWRKIDNLIH NFTRD
//
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