ID A0ELU3_9BIVA Unreviewed; 367 AA.
AC A0ELU3;
DT 28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=MyD88 {ECO:0000313|EMBL:ABB76627.1};
OS Azumapecten farreri.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Pectinida; Pectinoidea; Pectinidae;
OC Azumapecten.
OX NCBI_TaxID=106299 {ECO:0000313|EMBL:ABB76627.1};
RN [1] {ECO:0000313|EMBL:ABB76627.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17383200; DOI=10.1016/j.fsi.2007.01.012;
RA Qiu L., Song L., Yu Y., Xu W., Ni D., Zhang Q.;
RT "Identification and characterization of a myeloid differentiation factor 88
RT (MyD88) cDNA from Zhikong scallop Chlamys farreri.";
RL Fish Shellfish Immunol. 23:614-623(2007).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; DQ249918; ABB76627.1; -; mRNA.
DR AlphaFoldDB; A0ELU3; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0070976; F:TIR domain binding; IEA:InterPro.
DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:InterPro.
DR CDD; cd08312; Death_MyD88; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR034249; MyD88_Death.
DR InterPro; IPR017281; Myelin_different_resp_MyD88.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR15079; MYD88; 1.
DR PANTHER; PTHR15079:SF3; MYELOID DIFFERENTIATION PRIMARY RESPONSE PROTEIN MYD88; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF13676; TIR_2; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50104; TIR; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198}.
FT DOMAIN 48..113
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT DOMAIN 163..302
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 131..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 367 AA; 42379 MW; 5DBA01E31ACE8BB0 CRC64;
MAMADIENLI ESMKDVHVNS LNNGCRRRIA MYLNPEGSLI PDSDMFNDWC GYAELLNFSQ
PEIENMKRHK SPTEEMLHLW STRNDPEPKV GNLISFLCKL ERFDVISDCR TMIERDVEKW
RQNQLSLQKI NDDPTFREPQ SRPRSPQSEE TQTRADVGSK DEIYYDCFVI YNPDASDQLE
FVKQMSRILE GPEYNFRLFI PWRDDLVGTA MHSVSAAIIE KKCRRCIVVL SKSFNNSPAA
DFQLKFAHAL SPGARQKRVI PVLIENIEPP SILNFVAPAP FYNVGIRDWQ WPRVAATIKS
ELRPDPETWL PKVDAWNIAL DTSDVTKREL WGITVATQIY PEEDPVGIPD VDAQRKKHKN
KNKKRGE
//
