ID A0FAY4_9HIV1 Unreviewed; 210 AA.
AC A0FAY4;
DT 28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Pol protein {ECO:0000313|EMBL:ABJ95743.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:ABJ95743.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ABJ95743.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ABJ95743.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=1182.12-3098-20030512 {ECO:0000313|EMBL:ABJ95743.1};
RX PubMed=16928764; DOI=10.1128/JVI.00712-06;
RA Baxter J.D., Schapiro J.M., Boucher C.A., Kohlbrenner V.M., Hall D.B.,
RA Scherer J.R., Mayers D.L.;
RT "Genotypic changes in human immunodeficiency virus type 1 protease
RT associated with reduced susceptibility and virologic response to the
RT protease inhibitor tipranavir.";
RL J. Virol. 80:10794-10801(2006).
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DR EMBL; DQ880324; ABJ95743.1; -; Genomic_RNA.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral release from host cell {ECO:0000256|ARBA:ARBA00023113};
KW Virion maturation {ECO:0000256|ARBA:ARBA00023113}.
FT DOMAIN 7..197
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABJ95743.1"
FT NON_TER 210
FT /evidence="ECO:0000313|EMBL:ABJ95743.1"
SQ SEQUENCE 210 AA; 24806 MW; 28293752A64A0D2F CRC64;
CTELEZDGKI SKIGPENPYN TPVFAIKKKN STRWRKIVDF RELNKRTQDF WEVQLGLPHP
SGLKKKKSVT VLDVGDAYFS IPLDEDFRKY TAFTIPSVNN ETPGIRYQYN VLPQGWKGSP
AIFQSSMTKI LEPFRKQNPD IIIYQYVDDL YVGSDLEIEQ HRTKIKELRD YLYKWGFYTP
EQKHQKEPPF HWMGYELHPD KWTVHPIVLP
//
