ID A0FCL2_STRVO Unreviewed; 7178 AA.
AC A0FCL2;
DT 28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE SubName: Full=MerB {ECO:0000313|EMBL:ABJ97438.1};
GN Name=merB {ECO:0000313|EMBL:ABJ97438.1};
OS Streptomyces violaceusniger.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces violaceusniger group.
OX NCBI_TaxID=68280 {ECO:0000313|EMBL:ABJ97438.1};
RN [1] {ECO:0000313|EMBL:ABJ97438.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DSM 4137 {ECO:0000313|EMBL:ABJ97438.1};
RX PubMed=17159202; DOI=10.1099/mic.0.29176-0;
RA Sun Y., Hong H., Samboskyy M., Mironenko T., Leadlay P.F., Haydock S.F.;
RT "Organization of the biosynthetic gene cluster in Streptomyces sp. DSM 4137
RT for the novel neuroprotectant polyketide meridamycin.";
RL Microbiology 152:3507-3515(2006).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; DQ885223; ABJ97438.1; -; Genomic_DNA.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd08952; KR_1_SDR_x; 1.
DR CDD; cd08956; KR_3_FAS_SDR_x; 3.
DR CDD; cd00833; PKS; 4.
DR Gene3D; 3.30.70.3290; -; 4.
DR Gene3D; 3.40.47.10; -; 4.
DR Gene3D; 3.40.50.11460; -; 1.
DR Gene3D; 6.10.140.1830; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 4.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 4.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 3.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR041618; PKS_DE.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR015083; Polyketide_synth_docking.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 4.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR Pfam; PF08990; Docking; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 4.
DR Pfam; PF00109; ketoacyl-synt; 4.
DR Pfam; PF02801; Ketoacyl-synt_C; 4.
DR Pfam; PF08659; KR; 4.
DR Pfam; PF18369; PKS_DE; 1.
DR Pfam; PF21089; PKS_DH_N; 3.
DR Pfam; PF00550; PP-binding; 4.
DR Pfam; PF14765; PS-DH; 3.
DR SMART; SM00827; PKS_AT; 4.
DR SMART; SM00826; PKS_DH; 3.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 4.
DR SMART; SM00825; PKS_KS; 4.
DR SMART; SM00823; PKS_PP; 4.
DR SMART; SM01294; PKS_PP_betabranch; 4.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 4.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 10.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 4.
DR SUPFAM; SSF53901; Thiolase-like; 4.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00606; KS3_1; 4.
DR PROSITE; PS52004; KS3_2; 4.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
DR PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 33..455
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1638..1713
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1733..2159
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3224..3299
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3321..3748
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 5298..5373
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 5393..5819
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 7022..7097
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2161..2199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2820..2860
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4543..4568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2169..2193
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2836..2850
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 7178 AA; 750060 MW; 9D4999158FB1B247 CRC64;
MENEEKLRHY LKEVTKDLRQ TRQRLEDIEA KSREPIAIIG MSCRFPGGIA TPEALWDLVR
EGGDAVSDFP TDRGWDTEDL YDPAGGSGKS VTRYGGFLHG IADFDAALFG ISPREAIAMD
PQQRLMLETS WEAFERAGVH RDAVRGSRTG VFIGTNGQDY ATLLSAARDE VQGHLGTGSA
ASVLSGRVAY TFGLEGPTVT VDTACSSSLI ALHLAVQALR NGECELALAG GVTVMTTTNT
FVELSKQGGL APDGRSKAFA AAADGTGWGE GAGVLLVERL SDAERHGHPV LAVVCGTAAN
QDGASNGLTA PNGPAQRRVI RAALSNAQLS TGDVDVVEAH GTGTRLGDPI EAQALLDTYG
QDREQPLWLG SVKSNLGHAQ AAAGVAGASD GLAMRHGVLP RTLHVDEPTP HVDWSAGAIR
LLTERTPWPE TDRPRRAGVS AFGVSGTNAH VIVEQAPETE PIEPSRIEPV AVPCVLSGQG
EAGLRAFAAR LADVATEAHP GDLGWTLATT RSALSHRAVV IGSTPADLRS GLAAVAAGEP
APNVVEGVAG PDTGVVLVFP GQGSQWAGMA VELLDTSPAF ARRFAECARA LEAHLDWSIE
DVVRSVPGAP SLDLIEVVQP VLFTMMVSLA ELWSSYGITP SAVVGHSQGE IAAACVAGAL
SLEDAAKVVV LRSRLFAETL VGNGAIASVA LPAEQLATRI EPWGERLAVA GVNGPAAATV
AGDPQSLEEF VAACVADGVR ARVVPATVAS HGPQVEPLRE RLLALLADVA PRQSTVPFYS
TVTGGLLDTT ELDADYWFWN ARKPIDFLGA LHALFADGHR FFVESSTHPA LTMGIQDTAD
ASGESVVVTG SLRRGEGGLA QFCSAVARLH VHGVRVDWPA AFGAARRVEL PTYPFQRERY
WLTPRPGHGD ASALGLGALD HPLLGATAVL PESGGCLLTG RLSLATHPWL ADHALSGVVL
FPGAGFVELV LQAGLWLGCG VVEELTLEGP LVFSERGGVE VQVVVGGVGE GGVGGGGCRS
VSVFSCRGGE WVRHAVGVLG VGAGVVSGVE VWPPVGAVRV GVEGVYEGLA ERGYVYGPVF
QGLRDAWRRG DEVFVEVAVP AEARGDAARC AIHPALLDAA LHGVRFGDFV SDDDQAYVPF
SWTGVTLNAV GATALRVTLS PAGRDAIALR ATDTTGAPVL SARSLALRPL SAQQLDDTRG
SRTDALHRVE WVDASGAVAA GGEVASRTEV VRVVSEGADV VGEAYGHVLG VLERVRAWVG
DEDLAGERLV VVTRGAVDVG GGVEDVAGAA VWGLVRSAQS ENPGRLVLVD TDDVEGVGGV
LPGVLALGEE QVVVRSGVVR VPRLGRVRVS GEVSGVFGSG AVLVTGGTGV LGGVVSRHLV
VRHGVSRLVL LSRRGAEAEG AAELRAELEG AGAEVVIAAC DAADGEALAG VLAGLPEGFA
LSGVVHAAGV LDDGLLTSLT RERVEPVLRA KVDAAWNLHE LTAGMNLSAL VFFSSAAGVL
GNAGQSSYAA ANGFLDALAA HRRARGLPAV SIAWGFWEER SELTKHLSAD DLARAHAVPM
PTSQALDLFD AALAADEAMV LAAPLDPRAW SDADNPPAVL RDLVRPRIRR AAEVVDASGS
ASALEHRLAA VDRSEWDQVV RELVRNHIAA VLRHASAESV DTSRTFQEIG FDSLTAVELR
NRISAATGVR LPATAVFDYP TPRALADHLL AEALGKDIGA AAATPAGAAL VADDPIVIVG
MSCRYPGGIT SPEALWDLVR SGGDAISALP TDRGWDLDGL YDPDPDRPGR SYARSGGFVY
DAAEFDAAFF GISPREAAAM DPQQRLLLEA SWEAFERAGI PATSVKGERI GVFTGVMHHD
YLTRLSITPD GVEGYLGTGA AAGVASGRVA YTFGLEGPAV TVDTACSSSL VALHLAIQAL
RLGECSLALA GGVTVMSTPT VFVEFSRQRG LASDGKCKAF AGAADGTGFA EGIGMLLVER
LSDARRNGHP VLAVVRGSAV NQDGASNGLT APNGPSQQRV IRQALASAGL SAVDVDAVEA
HGTGTTLGDP IEAQALLATY GQGRDADRPL LLGSIKSNIG HTQAAAGVAG VIKMVMAMGH
GVLPQTLHID EPTPHVDWST GAVRLLGEHT EWPEAGRPRR AGVSSFGISG TNAHLILEQA
PLPTTAERPD DAEPGDAKSG DVRPGDVRPD DVRPRAAGPG AVVPWILSGR DRRALRAQAE
RLRAHVASHP DLSVADIGFS LLTSRAVLEH RAVVLGGDHA ELSAGLTALA QDEPAPGVVE
ALDAAEPGRK VVFVFPGQGS QWAGMALELL ESAPVFARRM GECAEALAPL VEWSLPDVLA
DERALGRVDV VQPVLWAVMV SLAELWRSYG VAPSAVVGHS QGEIAAACVA GGLSLADGAR
VVVLRGKALL ALSGRGGMVS VPVPADRLRD RPGVSIAAVN GPSSTVVSGG DEALDAVLVE
FPAAKRIPVD YASHSPQIDG IRDELLKALA PIEPRTAAIP FHSTVTGRPI DTAELDADYW
YRNLRETVEL ERVTRAAVED GHHTFIEISP HPVLTTGLRE TLDDADAHGG LVLASLRRDD
GGLTRFRTAL AEAYAYGVEV DWLSVFPGAR RVELPTYAFQ RERYWLDAPT AEAPTSAIDA
EFWAAVERED LESLAATLRV DGQPLREVLP ALSQWRRERR DVSTIDSWRY KIRWKPLTPP
ATCPTGTWLV VVSHAEAEHE WVAGVTGALT RHGAEPLVVV LGEPELDRAA LAARLGAALA
DTPRVSGVVS LTALDESPHP AYPSVPQGYA MTLLLSQALG DAGVEAPLWC LTQRGVSLGD
GGGNRGGAGG RGDEGNGSGN GNSTGSGSGN GPGEGDGDRD VAVSRKQALT WGLGKVIALE
QPLRWGGLID LPEGVAPYAQ DYLVGVLAGT SDEDQVAIRP TGLFGRRLAH APAPERGGAW
QPRGTVLVTG GTGALGGHVA RWLAAQGAEH VVLTSRRGMA APGAERLAGE LEALGARVTV
AACDVGDRDA LAALLTEVGP LTAVVHTAAV LDDATLNSLT TEQLQRVLRV KTDGAVHLHE
LTRDMELSAF VLFSSLSGTL GAPGQGNYAP GHVFVDTLAE QRRAEGLVAT SIAWGLWAGD
GMGEGGVGEV ARRHGVPEMA PEMAVAAMAR AVEQDDTVVT VAEIDWDRHY VAFTATRPSP
LLSDLPEVRA LIDAGVGQES AEPGHERSEF AERLAGMADA DRNRALLDLV RRHVAVVLGH
TGPDAIDPGR AFHEIGFDSV TAVELRNRLN RATGLRLPAT VTFDQPTPLA MARYLRGELL
HDGQDRSAPA RPVRTTGAVD DEPIAIVGMS CRFPGDVASP EDLWRLLADG SDAIGEFPEN
RGWDTAHLFH PDPDHRGTSS TRAAAFVSGA GEFDAGFFGI SPREAVAMDP QQRLLLEVSW
EALERAGIDP STLRGSETGV FTGTNGQDYA SLLKADETGD FEGRVGTGNS ASVMSGRISY
VLGLEGPALT VDTACSSSLV ALHLAVRALR SGECSLALAG GASVMTTTGI FVEFSRQRAL
AADGRCKAFA AGADGTGWGE GVGMLVVERL SDAERNGHRV LAVVRGSAVN QDGASNGLTA
PNGPSQQRVI RQALASAGLS AVDVDVVEAH GTGTTLGDPI EAQALLATYG QGRDVDRPLL
LGSIKSNIGH TQAAAGVAGV IKMVMAMGHG VLPQTLHIDE PTPHVDWSTG AVRLLDEQTD
WPETARPRRA GVSAFGVSGT NAHVILEQAP APTAEPELSP ERDETRAVPW VVTGASEAGV
RAQAARLMAF VDDRPELRPV DIGWSLVSTR AALPHRAVVV GGDRDELVRE LEAVAGGSAA
IGEARTHSGV VFVFPGQGSQ WVGMALELVE SSSVFAGRLG ECADVLAPLV EWSLWDVLGD
EVALSRVDVV QPVLWAVMVS LAELWRSFGV VPSVVVGHSQ GEIAAACVAG GLSLEDGARV
VALRSRALLA LSGRGGMVSV PVPADRLRDR PGLSVAAVNG PVSTVVSGSV EALDAVLEEF
PEAKRIPVEY ASHSVQVEEI REGLAEALAS VRPRTGEVPF YSTVTGRLMD TVELDAEYWY
RNLRETVEFR SAVEGLLELG HTVFVEASPH PVLTVGIQDT ADATDTTHTD ILVTGSLRRD
DGGLVRFLST VGRLFTAGVP VEWQPLFAAA GARRVDLPTY AFQHEWFWLD PVRGASDVGG
AGLAGLAHPL VSAVLPLPES DGCVLTGSLS SATHPWLRDH AVLDKVLLPG TGFVELALQA
GLHLGCRTLD ELTLQAPLVL PAHGDVQIQV AVGGPDDSGR RPVTVYSRPG QDRTWVRHAT
GSVSPGGETA TVDRTVWPPV DATPVDLTGV YAEMNTRGYA YGPVFQGLRA AWRRGDEVFA
EVVLSETAES DAGRCAVHPA LLDAALHGAG LGTFVTEPGR PHLPFAWTGV SLHAVGATTL
RVVLSPAGPD AISLLAMDGT GAPVLTADSL ALRPVSGGTR GGAHNDSLFR VDWTELALAA
SDTSDEVAFP VVESLAQLTG PGAPQPVHGA VVFRPFATEA SATEAPATEA SVAGATDATG
AADTTEENPE DVYALTSRVL EVAQAWLADD RFGDARLVVV TRGAVATRPG EDPESLAAAA
VWGLIRTAQT ENPGRFVLVD TVDEDPSVSS VSSVSSTSSV VSALPAVLAT DEPQVAIRAG
KALVPRLVRA ASSALPVPAE TDTWRLEADG QGTLENLVLA PHAEASRPLA THEIRVAVRA
AGVNFRDVLL ALGMYPDKAG LLGSEAAGTV LEIGSGVAGV APGDRVMGLF SGAFGPVAIT
DHRLVAPIPA GWSFPQAAAT PIAFLTAMYA LIDLADVRSG ESVLVHAAAG GVGMAAVQVA
RWLGAEVFAT ASPAKWDAVR ACGVAQQRIA SSRSTEFADR LRSDAPGGVD VVLNSLTGEL
LNASLGLLRP GGRLIEMGRT DLRDAEEVMA RHGVSYRAFE LLDAGPDRIG RLLTELLSLF
RQGVFTPLPL RVQDVRQASD AFRHLSQARH IGKLALTIPR PLSGGTALIT GGTGTLGGLV
ARHLVREHGV TELVLVGRRG DTAPGAAELL TELEAAGARV RVVACDVSDR EATAALVASL
PNLRSVVHTA GVLDDAVIGS LTPERLRTVL RPKADAAWHL HELTRDRDLA EFVLFSSAAG
VLGGPGQGNY AAANAFLDAL AARRRAQGLP ATSLAWGFWE QRSGLTEHLT TDRLARSGVL
PLSTDEGLAL FDAARATGDT LLVPMRYEPS APGPEPVPAL LRGLVRAPLA RALPGPADGV
GNGVTEGLTG LAVDERLGVL LDLVRREAAA VLGHGGPQSV TPRRPFKELG FDSLSAVELR
NRLRTATGRR LEATLIFDHP TPAALARHLD AELFGATDVA APVPAPTVAH PADERIAIVG
MSCRLPAGVD SPEALWTLLM SGTDAISELP TDRGWSLDAL YDQDPSRPGT TYAKTGGFLK
NAADFDAGFF TISPREALAA DPQQRLWLEA CWEAFERAGI DPLALKGTRT GVFAGAASTT
YGAGQAAAPD GSEGYLLTGN STSVISGRVA YTLGLEGPAV TVDTACSSSL VSVHWACESL
RRGESTLALA GGVAVMTTPD LLVEFSRQRG LAPDGRCKSF AAAADGTGFA EGAGVLVLER
LSDAERNGHQ VLAVIRGSAV NQDGASNGLT APNGPSQQRV IRQALANAGL ASQEVDAVEA
HGTGTTLGDP IEAQALLATY GQDRDPDRPL LLGSVKSNIG HTQAAAGAAG LIKMVLALRN
GVLPRTLHVD EPSPHVDWSA GAMELLTEQT TWPDRDRPRR AGVSAFGVSG TNAHVILEQA
PKPDENGEPD TGRSGLPAVP WVLSGAGAAG LRAQAQRLAS FVRENPELDP VDVGWSLVAT
RAALSHRAVV VGADRTELLR ELDAVQSVGA AEAGRDVVFV FPGQGSQWVG MALELVESSS
VFAGRLGECA DVLAPLVEWS LWDVLGDEVA LSRVDVVQPV LWAVMVSLAE LWRSFGVVPS
VVVGHSQGEI AAACVAGGLS LEDGARVVAL RSKALLALSG RGGMVSVPVS ADQLRDRPGL
SVAAVNGPVS SVVSGPVEVL DAVLEEFPEA KRIPVDYASH SSQVEEIRGE LAEALVSVRP
RTGEVPFYST VTGRLMDTVE LDGEYWYRNL RETVEFQSTV EHLMREGHTV FVEASPHPVL
TVGIQDTADA TVTDIVITGS LRRDEGGVRR FLTSLAEVSV RGVEVNWWTA FDGAGARRVD
LPTYAFQRER FWLAPSTGTG DAYGLGLGAV DHPLLGAAVP LPDADGCVLT GALSLAGQPW
LADHSVLGMV LLPGTAFVEL ALQAGARFGC DTLEELTLHE PLVLPEQETV QLQVSVGGPD
DLGSRPFTVF SRREGDWTRH AGGTLCVGEH GDPPANPSVW PPADARPVDV AELHMTMAER
GYQYGPAFQG LRKAWIRDSE VFLDVALPEL VRGDAARCGV HPALLDAALQ GIGLGAFVSE
PGRAHLPFSW SGVTLHAVGA TTVRVTLSPA GPDAVAIRMT DTIGAPVLSI DVLAMRPLAE
QRLLEAGGPR GDALFRLDWT ELPVPTGATG PRALSWGLLG GHDEPRLTAA LTAVGVSPQR
HRDLASIDQV PDVLVLPCLP EADDGPAPEA TSSTLGRVLE VVREWLGDAR YTDTRLVVLT
RRAVATSTGD DVEDLAAAAV RGLLRTAQQE NPDRLVVIDH DDSDLGVLPA VLATGEPEAA
IRAGTVLVPR LVKAAVPDGK TPAWDTGTVL ITGGTGTLGG LVARHLVTTH GARDLVLASR
GGDTAPGAVE LATELEALGA SIRVAACDVA DRAQLTALLD TIPALRAVVH TAGVVDDGVI
GSMTADRVEA VLRPKANAAW HLHELTRRLD LDAFVLFSSA TGVLGSAGQG NYAAANAFLD
ALAVHRRAQG LPAVSVAWGL WEQRSGLTAH LSEQDMARMT RTGAIPLSDE RGLELFDAVC
RSGEATLVAT PLHLRAVAAT GTVPPVLSAL APAPPRRATE AGDGGVALRQ SLAELSGAEQ
SQAVRELVRG QVAAVLRHPD GSAIDPVRTF QEIGFDSLTA VELRNRLGAS TGIRLAATAI
FDYPTPATLA EHLLAEIVPE TADPVAARLG ELDKVAAMIS AMGEDDTLRE QLSSRMETIV
AMWADLHRPE RSSRVGRDLE SASLDDMFGI IDQELDGS
//
