ID A0JML2_DANRE Unreviewed; 452 AA.
AC A0JML2;
DT 12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT 12-DEC-2006, sequence version 1.
DT 27-MAR-2024, entry version 118.
DE RecName: Full=Bone morphogenetic protein 3 {ECO:0000256|ARBA:ARBA00013361, ECO:0000256|PIRNR:PIRNR037403};
GN Name=bmp3 {ECO:0000313|RefSeq:NP_001071233.1,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-7192};
GN Synonyms=zgc:153939 {ECO:0000313|RefSeq:NP_001071233.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI25920.1};
RN [1] {ECO:0000313|RefSeq:NP_001071233.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17205186; DOI=10.1100/tsw.2006.326;
RA Schebesta M., Lien C.L., Engel F.B., Keating M.T.;
RT "Transcriptional profiling of caudal fin regeneration in zebrafish.";
RL ScientificWorldJournal 6 Suppl 1:38-54(2006).
RN [2] {ECO:0000313|EMBL:AAI25920.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=PCR rescue {ECO:0000313|EMBL:AAI65587.1}, and Whole
RC {ECO:0000313|EMBL:AAI25920.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001071233.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18074148;
RA Macqueen D.J., Johnston I.A.;
RT "Evolution of follistatin in teleosts revealed through phylogenetic,
RT genomic and expression analyses.";
RL Dev. Genes Evol. 218:1-14(2008).
RN [4] {ECO:0000313|RefSeq:NP_001071233.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20828405;
RA Mueller R.L., Huang C., Ho R.K.;
RT "Spatio-temporal regulation of Wnt and retinoic acid signaling by
RT tbx16/spadetail during zebrafish mesoderm differentiation.";
RL BMC Genomics 11:492-492(2010).
RN [5] {ECO:0000313|RefSeq:NP_001071233.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22876193;
RA Schoenebeck J.J., Hutchinson S.A., Byers A., Beale H.C., Carrington B.,
RA Faden D.L., Rimbault M., Decker B., Kidd J.M., Sood R., Boyko A.R.,
RA Fondon JW 3.r.d., Wayne R.K., Bustamante C.D., Ciruna B., Ostrander E.A.;
RT "Variation of BMP3 contributes to dog breed skull diversity.";
RL PLoS Genet. 8:e1002849-e1002849(2012).
RN [6] {ECO:0000313|RefSeq:NP_001071233.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23028974;
RA Wang X., He H., Tang W., Zhang X.A., Hua X., Yan J.;
RT "Two origins of blastemal progenitors define blastemal regeneration of
RT zebrafish lower jaw.";
RL PLoS ONE 7:e45380-e45380(2012).
RN [7] {ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [8] {ECO:0000313|RefSeq:NP_001071233.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25328556;
RA Ito-Amano M., Nakamura Y., Morisaki M., He X., Hayashi M.,
RA Watanapokasin R., Kato H.;
RT "Temporal and spatial expression patterns of bone morphogenetic protein 3
RT in developing zebrafish.";
RL Open Rheumatol J 8:69-72(2014).
RN [9] {ECO:0000313|RefSeq:NP_001071233.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26420840;
RA Schuster K., Leeke B., Meier M., Wang Y., Newman T., Burgess S.,
RA Horsfield J.A.;
RT "A neural crest origin for cohesinopathy heart defects.";
RL Hum. Mol. Genet. 24:7005-7016(2015).
RN [10] {ECO:0000313|RefSeq:NP_001071233.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29110609;
RA Lei D., Jin X., Wen L., Dai H., Ye Z., Wang G.;
RT "bmp3 is Required for Integrity of Blood Brain Barrier by Promoting
RT Pericyte Coverage in Zebrafish Embryos.";
RL Curr. Mol. Med. 17:298-303(2017).
RN [11] {ECO:0000313|RefSeq:NP_001071233.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28627438;
RA Chen L., Dong C., Kong S., Zhang J., Li X., Xu P.;
RT "Genome wide identification, phylogeny, and expression of bone
RT morphogenetic protein genes in tetraploidized common carp (Cyprinus
RT carpio).";
RL Gene 627:157-163(2017).
RN [12] {ECO:0000313|RefSeq:NP_001071233.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29202482;
RA Venkatesan A.M., Vyas R., Gramann A.K., Dresser K., Gujja S., Bhatnagar S.,
RA Chhangawala S., Gomes C.B.F., Xi H.S., Lian C.G., Houvras Y.,
RA Edwards Y.J.K., Deng A., Green M., Ceol C.J.;
RT "Ligand-activated BMP signaling inhibits cell differentiation and death to
RT promote melanoma.";
RL J. Clin. Invest. 128:294-308(2018).
RN [13] {ECO:0000313|RefSeq:NP_001071233.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR037403}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|PIRNR:PIRNR037403,
CC ECO:0000256|RuleBase:RU000354}.
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DR EMBL; BC125919; AAI25920.1; -; mRNA.
DR EMBL; BC165587; AAI65587.1; -; mRNA.
DR RefSeq; NP_001071233.1; NM_001077765.1.
DR GeneID; 777717; -.
DR KEGG; dre:777717; -.
DR AGR; ZFIN:ZDB-GENE-030131-7192; -.
DR CTD; 651; -.
DR ZFIN; ZDB-GENE-030131-7192; bmp3.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000000437; Alternate scaffold 5.
DR Proteomes; UP000000437; Chromosome 5.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IMP:ZFIN.
DR GO; GO:0001649; P:osteoblast differentiation; IEA:InterPro.
DR CDD; cd19393; TGF_beta_BMP3; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR017197; BMP3/BMP3B.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF144; BONE MORPHOGENETIC PROTEIN 3; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR PIRSF; PIRSF037403; BMP3/GDF10; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Cytokine {ECO:0000256|PIRNR:PIRNR037403};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR037403-1};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|PIRNR:PIRNR037403};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 340..452
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 301..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 350..417
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
FT DISULFID 379..449
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
FT DISULFID 383..451
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
FT DISULFID 416
FT /note="Interchain"
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
SQ SEQUENCE 452 AA; 51976 MW; F1564153DC34EFA5 CRC64;
MDRCQRLFVL LLGCGYLCCG YCAVLKTPVM GFSKDVQLGQ KAEEPEKQHV KKSEQDTLSE
HMQMLYAKYT SAGFPLKDGN TVRSFKGHLG TINNRQLQIF NLTSLTKSED VLSATLHYYI
GDLHNSSHRC SKHKSCAQHN LRRQAHVHLD VWSFSLVKNT TRTIGHFPIN ISTMHWDFIS
WQWKDITRVV NQAKHHDQLL IGININSRGH QPWKKLLSDR SPYILVYAND SAISEPESVV
STLQRHKSRL LPNLHMLESH NRNASAQHRS RRSTNILLPL QNNELPGPEY PYEIPTWDEA
SPYDPMESKT VKRPRKKPRK NPRHKNPLLQ FDEQTIKKAR KKQWNEPRNC ARRYLKVDFA
DIGWSEWIIS PKSFDAYYCS GSCQFPMPKS LKPSNHATIQ SIVRAVGVVP GIPEPCCVPE
KMSSLSILFF DEDKNVVLKV YPNMTVDSCA CR
//
