ID A0KEL2_AERHH Unreviewed; 645 AA.
AC A0KEL2;
DT 12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT 12-DEC-2006, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Acetoacetyl-CoA synthase {ECO:0000313|EMBL:ABK36572.1};
DE EC=6.2.1.16 {ECO:0000313|EMBL:ABK36572.1};
GN OrderedLocusNames=AHA_0140 {ECO:0000313|EMBL:ABK36572.1};
OS Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC
OS 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Aeromonadales;
OC Aeromonadaceae; Aeromonas.
OX NCBI_TaxID=380703 {ECO:0000313|EMBL:ABK36572.1, ECO:0000313|Proteomes:UP000000756};
RN [1] {ECO:0000313|EMBL:ABK36572.1, ECO:0000313|Proteomes:UP000000756}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 /
RC KCTC 2358 / NCIMB 9240 / NCTC 8049
RC {ECO:0000313|Proteomes:UP000000756};
RX PubMed=16980456; DOI=10.1128/JB.00621-06;
RA Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.,
RA Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S.,
RA Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades.";
RL J. Bacteriol. 188:8272-8282(2006).
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DR EMBL; CP000462; ABK36572.1; -; Genomic_DNA.
DR RefSeq; WP_011704166.1; NC_008570.1.
DR RefSeq; YP_854677.1; NC_008570.1.
DR AlphaFoldDB; A0KEL2; -.
DR STRING; 380703.AHA_0140; -.
DR EnsemblBacteria; ABK36572; ABK36572; AHA_0140.
DR KEGG; aha:AHA_0140; -.
DR PATRIC; fig|380703.7.peg.133; -.
DR eggNOG; COG0365; Bacteria.
DR HOGENOM; CLU_000022_3_3_6; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000000756; Chromosome.
DR GO; GO:0030729; F:acetoacetate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd05943; AACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR005914; Acac_CoA_synth.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR01217; ac_ac_CoA_syn; 1.
DR PANTHER; PTHR42921; ACETOACETYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR42921:SF1; ACETOACETYL-COA SYNTHETASE; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ABK36572.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000756}.
FT DOMAIN 37..92
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 95..466
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 538..607
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 645 AA; 72519 MW; A1B97AD3E45CCC95 CRC64;
MHNLCLWQPD QERIQQSNLQ HFMAEVNRFH GLQLHSYAQL YQWSVEKTTR FWPLVWQHCG
VKGELGNIVA ENRQEMQRTR WFPDSRLNFA ENLLRRQDDT PAIISRIEGS PSQTLSWREL
ADQVARLAQW LRGQGIGRGD VVAAYLPNIP QTVVAMLATT SLGAIWTSTS PDFGEASVVE
RFGQTRPRVL FAVDGYHYNG KAIDIQDKVA GVVGQIDSIE QTVIIPLLGH PLQLGHDWRQ
ILASQPDASL QFEPMAFNDP LYILYSSGTT GKPKCIVHGI GGTLLQHLKE HQLHCDIKPG
ERIFYFTTCG WMMWNWLVSA LASGATLVLY DGSPFYPDGN VLWDLARDEE VALFGTSAKY
LDALHKQGYA PIKTHQLPQL RLICSTGSVL SPEGFDYVYQ QIKRDVQLSS ISGGTDICSC
FVIGNPISPV YRGESQGRGL GLAVQVFNEA GQPVQGEKGE LVCTKPFPAQ PIGFWGDASG
DKYHAAYFER FDNIWCHGDW IELTPTGGIL FYGRSDATLN PGGVRIGTSE IYRYVEQLEE
VEESIVIGQQ WQQDERVVLF VKLKPGLMLD EALRERIRQQ VRLHCTARHV PARILQVDAI
PRTKSGKIVE LAVREVVHNR PVNNTHALAD PEVLSQYRDR PELAS
//
