ID A0L324_SHESA Unreviewed; 567 AA.
AC A0L324;
DT 12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT 12-DEC-2006, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=Shewana3_4240 {ECO:0000313|EMBL:ABK50456.1};
OS Shewanella sp. (strain ANA-3).
OG Plasmid pANA-3 {ECO:0000313|Proteomes:UP000002589}.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Shewanellaceae; Shewanella.
OX NCBI_TaxID=94122 {ECO:0000313|EMBL:ABK50456.1, ECO:0000313|Proteomes:UP000002589};
RN [1] {ECO:0000313|Proteomes:UP000002589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ANA-3 {ECO:0000313|Proteomes:UP000002589};
RC PLASMID=Plasmid pANA-3 {ECO:0000313|Proteomes:UP000002589};
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Newman D.,
RA Salticov C., Konstantinidis K., Klappenback J., Tiedje J., Richardson P.;
RT "Complete sequence of plasmid 1 of Shewanella sp. ANA-3.";
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CP000470; ABK50456.1; -; Genomic_DNA.
DR RefSeq; WP_011711576.1; NC_008573.1.
DR AlphaFoldDB; A0L324; -.
DR REBASE; 14073; M.SspANAORF4240P.
DR KEGG; shn:Shewana3_4240; -.
DR eggNOG; COG0286; Bacteria.
DR HOGENOM; CLU_013049_4_1_6; -.
DR OrthoDB; 9784823at2; -.
DR Proteomes; UP000002589; Plasmid pANA-3.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42998:SF1; TYPE I RESTRICTION ENZYME HINDI METHYLASE SUBUNIT; 1.
DR PANTHER; PTHR42998; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:ABK50456.1};
KW Plasmid {ECO:0000313|EMBL:ABK50456.1};
KW Transferase {ECO:0000313|EMBL:ABK50456.1}.
FT DOMAIN 12..178
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 190..526
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 567 AA; 64069 MW; 7AC239ED89E1AB1D CRC64;
MNELEQEFLK DLEKKLWNAA DKLRATLDAS QYKHAVLGLI FVKYVSDAFS MRQEEIKADL
TNPEHEYYLD PADFSEDELA EEIAAELEVR DFYTEKNVFW LPTESRWKFL QDNGPMVIGG
ADLVIDGKTK KITSVGHLID NALEGIERDN QKLKGVLNKH YASLKIDQAK LNELINLIAT
IPFNHKSLNS KDILGHIYEY FLGQFALAEG KKGGQFYTPA SIVSLIVEMI EPFEGRVYDP
AMGSGGFFVQ SEKFIERRAN QKEIDPLTQK QRISIYGQEY NYTTWQLAAM NMAIRGLDYD
FGKEPASTYT NDQHPDLRAD FIMANPPFNM KEWNTGVDDN DPRWVYGTPP SGNANFAWMQ
HMLYHLAPDG SQALLLANGS MSSTTNNEGE IRAALVENDL VECMVALPGQ LFTNTQIPAC
IWFLAKNKKA RTDKSGRKLR DRKGEVLFID ARNLGYMKDR VLRDFTQDDI QKVADLYHAW
KTGAEVNGIA YEDQAGFCKS ATLEEIKKHD FVLTPGRYVG ATEELDDGIP FGEKMATLTS
KLSDQFAESA TLEAEIKKNL AGLGYDL
//
