ID A0LF55_SYNFM Unreviewed; 500 AA.
AC A0LF55;
DT 12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT 12-DEC-2006, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=D-lactate dehydratase {ECO:0000256|ARBA:ARBA00013134};
DE EC=4.2.1.130 {ECO:0000256|ARBA:ARBA00013134};
GN OrderedLocusNames=Sfum_0357 {ECO:0000313|EMBL:ABK16057.1};
OS Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB).
OC Bacteria; Thermodesulfobacteriota; Syntrophobacteria; Syntrophobacterales;
OC Syntrophobacteraceae; Syntrophobacter.
OX NCBI_TaxID=335543 {ECO:0000313|EMBL:ABK16057.1, ECO:0000313|Proteomes:UP000001784};
RN [1] {ECO:0000313|EMBL:ABK16057.1, ECO:0000313|Proteomes:UP000001784}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10017 / MPOB {ECO:0000313|Proteomes:UP000001784};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E.G.,
RA Martinez M., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Kim E., Boone D.R., Brockman F., Culley D., Ferry J., Gunsalus R.,
RA McInerney M.J., Morrison M., Plugge C., Rohlin L., Scholten J., Sieber J.,
RA Stams A.J.M., Worm P., Henstra A.M., Richardson P.;
RT "Complete sequence of Syntrophobacter fumaroxidans MPOB.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + methylglyoxal = (R)-lactate + H(+);
CC Xref=Rhea:RHEA:27754, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16004, ChEBI:CHEBI:17158; EC=4.2.1.130;
CC Evidence={ECO:0000256|ARBA:ARBA00001524};
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DR EMBL; CP000478; ABK16057.1; -; Genomic_DNA.
DR RefSeq; WP_011697230.1; NC_008554.1.
DR AlphaFoldDB; A0LF55; -.
DR STRING; 335543.Sfum_0357; -.
DR KEGG; sfu:Sfum_0357; -.
DR eggNOG; COG0693; Bacteria.
DR HOGENOM; CLU_545038_0_0_7; -.
DR InParanoid; A0LF55; -.
DR OrthoDB; 9792284at2; -.
DR Proteomes; UP000001784; Chromosome.
DR CDD; cd03141; GATase1_Hsp31_like; 1.
DR Gene3D; 3.40.50.880; -; 2.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR002818; DJ-1/PfpI.
DR InterPro; IPR032633; ThiJ-like.
DR PANTHER; PTHR48094:SF11; GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED; 1.
DR PANTHER; PTHR48094; PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED; 1.
DR Pfam; PF01965; DJ-1_PfpI; 1.
DR Pfam; PF17124; ThiJ_like; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001784};
KW Stress response {ECO:0000256|ARBA:ARBA00023016}.
FT DOMAIN 9..189
FT /note="DJ-1/PfpI"
FT /evidence="ECO:0000259|Pfam:PF01965"
SQ SEQUENCE 500 AA; 55859 MW; DA0F8EA1271C8D7A CRC64;
MADKPLSNKK VAILVESQYI PEELRAYREK FEAYGATCHF VSRLWGQSSQ TFISELEDPQ
GTPETFRVDI DVESVRPEDY AAVIMAANYT SVRLRYFSPP HTMRDTPAVK FFADAMRNPR
IVKGALCHGL WILTPTPELL TGRKVICHEV VASDIVNAGA VITPSTSGIV VDRDLVTGHS
KNEAGAMVDA IKELLTAPAL IPDPPRFSLS DVKPGRRRVL VLLSEFGYWG EELVGPVEVF
DAAGYRADFL TPTGKRPVAI TVSMNPEYTD PPLGRSVTSK EVAARTREWD DPATVQGRRL
ETPLNLSEWF PDRPYWSAPQ FIRAMEHYNR ALDRARREIE NYDALLIVGG SGPICDLANN
HRVHDLILGF HRADKPIAAE CYGVACLAFA RELEDRKSLI WGKHVTGHCK EYDYKDGTGF
MKARGQFYDI NMGPPPYPLE YILRDATGPE GGFHGNVGRE TSVIVDYPFI TGRSTPDSYL
TGQKLVEVLD GEPPLRRFGW
//
