ID   A0P6E5_9PROT            Unreviewed;       288 AA.
AC   A0P6E5;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   13-SEP-2023, entry version 35.
DE   SubName: Full=Prephenate dehydrogenase:Ketopantoate reductase ApbA/PanE:NAD-dependent glycerol-3-phosphate {ECO:0000313|EMBL:EAV47105.1};
GN   ORFNames=MB2181_03490 {ECO:0000313|EMBL:EAV47105.1};
OS   Methylophilales bacterium HTCC2181.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales; OM43 clade.
OX   NCBI_TaxID=383631 {ECO:0000313|EMBL:EAV47105.1, ECO:0000313|Proteomes:UP000054262};
RN   [1] {ECO:0000313|EMBL:EAV47105.1, ECO:0000313|Proteomes:UP000054262}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HTCC2181 {ECO:0000313|EMBL:EAV47105.1,
RC   ECO:0000313|Proteomes:UP000054262};
RA   Giovannoni S., Vergin K., Ferriera S., Johnson J., Kravitz S., Beeson K.,
RA   Sutton G., Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAV47105.1}.
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DR   EMBL; AAUX01000001; EAV47105.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0P6E5; -.
DR   OrthoDB; 9809920at2; -.
DR   Proteomes; UP000054262; Unassembled WGS sequence.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:InterPro.
DR   GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0006571; P:tyrosine biosynthetic process; IEA:InterPro.
DR   Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR046825; PDH_C.
DR   InterPro; IPR046826; PDH_N.
DR   InterPro; IPR003099; Prephen_DH.
DR   PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR   Pfam; PF20463; PDH_C; 1.
DR   Pfam; PF02153; PDH_N; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS51176; PDH_ADH; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054262}.
FT   DOMAIN          2..288
FT                   /note="Prephenate/arogenate dehydrogenase"
FT                   /evidence="ECO:0000259|PROSITE:PS51176"
SQ   SEQUENCE   288 AA;  31688 MW;  8D1B1410A4CE250B CRC64;
     MKNLLIFGVG LIGGSIALKV KKDAIFDRVI GVSRHNGRSL DDFVKKGMLD EIAVNVEEAI
     STANFIIIAT PVAQTKNILK KIYPYLNADC LVTDVGSTKS EVMLDAAESL GDKFDQFIGS
     HPIAGSEKHG PDAADEKLFE GKNIIITPHS QANKVQLDCL WGFWECMGGI VSSMTPSQHD
     EIFSTVSHLP HLLAFALVNL INKKNSKDQL LEFAASGFRD FSRIAASSPE VWRDISLANK
     KAIISDLTLY KKEIDVLVEF IDNSQEGNLN DYLSKASSTR SEWAEDKK
//