ID   A0PT37_MYCUA            Unreviewed;       435 AA.
AC   A0PT37;
DT   09-JAN-2007, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2007, sequence version 1.
DT   27-MAR-2024, entry version 86.
DE   RecName: Full=HRDC domain-containing protein {ECO:0000259|PROSITE:PS50967};
GN   OrderedLocusNames=MUL_3315 {ECO:0000313|EMBL:ABL05506.1};
OS   Mycobacterium ulcerans (strain Agy99).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium ulcerans group.
OX   NCBI_TaxID=362242 {ECO:0000313|EMBL:ABL05506.1, ECO:0000313|Proteomes:UP000000765};
RN   [1] {ECO:0000313|EMBL:ABL05506.1, ECO:0000313|Proteomes:UP000000765}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Agy99 {ECO:0000313|EMBL:ABL05506.1,
RC   ECO:0000313|Proteomes:UP000000765};
RX   PubMed=17210928; DOI=10.1101/gr.5942807;
RA   Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T.,
RA   Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J.,
RA   Johnson P.D., Davies J.K., Jenkin G.A., Small P.L., Jones L.M., Tekaia F.,
RA   Laval F., Daffe M., Parkhill J., Cole S.T.;
RT   "Reductive evolution and niche adaptation inferred from the genome of
RT   Mycobacterium ulcerans, the causative agent of Buruli ulcer.";
RL   Genome Res. 17:192-200(2007).
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DR   EMBL; CP000325; ABL05506.1; -; Genomic_DNA.
DR   RefSeq; WP_011741115.1; NC_008611.1.
DR   AlphaFoldDB; A0PT37; -.
DR   GeneID; 72433438; -.
DR   KEGG; mul:MUL_3315; -.
DR   eggNOG; COG0349; Bacteria.
DR   HOGENOM; CLU_042387_3_0_11; -.
DR   Proteomes; UP000000765; Chromosome.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR   CDD; cd06142; RNaseD_exo; 1.
DR   Gene3D; 1.10.150.80; HRDC domain; 2.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR041605; Exo_C.
DR   InterPro; IPR010997; HRDC-like_sf.
DR   InterPro; IPR002121; HRDC_dom.
DR   InterPro; IPR044876; HRDC_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR47649; RIBONUCLEASE D; 1.
DR   PANTHER; PTHR47649:SF1; RIBONUCLEASE D; 1.
DR   Pfam; PF01612; DNA_pol_A_exo1; 1.
DR   Pfam; PF18305; DNA_pol_A_exoN; 1.
DR   Pfam; PF00570; HRDC; 1.
DR   SMART; SM00474; 35EXOc; 1.
DR   SMART; SM00341; HRDC; 1.
DR   SUPFAM; SSF47819; HRDC-like; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50967; HRDC; 1.
PE   4: Predicted;
FT   DOMAIN          245..325
FT                   /note="HRDC"
FT                   /evidence="ECO:0000259|PROSITE:PS50967"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          321..340
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   435 AA;  47123 MW;  6E084B01BEDC3373 CRC64;
     MCSALSPEGN EPPEGTAPEA TPLLSPASGV PELSVTAGQI EAAATLLDRG SGPFAVDAER
     ASGFRYSNRA YLIQIRRAGA GTVLIDPVSH GGDPLTVLQP LAEVLAKDEW ILHSADQDLP
     CLAEVGMRPS ALYDTELAGR LAGYDRVNLA TMVERLLGMG LVKGHGAADW SKRPLPSDWL
     NYAALDVELL IELRSAISGV LAEQGKSDWA AQEFEYLRTF ESRWVPATAK PDRWRRTSGI
     HKVRDRRGLA AVRELWITRD RIAERRDIAP RRILPDSAII DAALSDPKSV EDLVSLPVFG
     GRNQRRNATM WLGALDVARK SQHPPEVAEP SNGPPVPARW SRRKPEAAAR LEAARAALSE
     VSDSVGVPTE NLVTPELVRR LCWDWAPVAA AEITSTIDEF LATGQARVWQ RELVVPALAA
     ALANAAEPET EPGAR
//