ID   PHEA_MYCA1              Reviewed;         315 AA.
AC   A0Q994;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   01-MAY-2013, entry version 42.
DE   RecName: Full=Prephenate dehydratase;
DE            Short=PDT;
DE            EC=4.2.1.51;
GN   Name=pheA; OrderedLocusNames=MAV_0188;
OS   Mycobacterium avium (strain 104).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC   Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=243243;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=104;
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Prephenate = phenylpyruvate + H(2)O + CO(2).
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Contains 1 ACT domain.
CC   -!- SIMILARITY: Contains 1 prephenate dehydratase domain.
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DR   EMBL; CP000479; ABK64544.1; -; Genomic_DNA.
DR   RefSeq; YP_879482.1; NC_008595.1.
DR   ProteinModelPortal; A0Q994; -.
DR   STRING; 243243.MAV_0188; -.
DR   EnsemblBacteria; ABK64544; ABK64544; MAV_0188.
DR   GeneID; 4527988; -.
DR   KEGG; mav:MAV_0188; -.
DR   PATRIC; 17982120; VBIMycAvi38287_0181.
DR   eggNOG; COG0077; -.
DR   HOGENOM; HOG000018970; -.
DR   KO; K04518; -.
DR   OMA; LAFPIND; -.
DR   ProtClustDB; PRK11898; -.
DR   BioCyc; MAVI243243:GH3Y-235-MONOMER; -.
DR   UniPathway; UPA00121; UER00345.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004664; F:prephenate dehydratase activity; ISS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0033585; P:L-phenylalanine biosynthetic process from chorismate via phenylpyruvate; ISS:UniProtKB.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00800; PDT; 1.
DR   PROSITE; PS00857; PREPHENATE_DEHYDR_1; FALSE_NEG.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Lyase; Phenylalanine biosynthesis.
FT   CHAIN         1    315       Prephenate dehydratase.
FT                                /FTId=PRO_0000382031.
FT   DOMAIN        3    189       Prephenate dehydratase.
FT   DOMAIN      202    268       ACT.
FT   SITE        182    182       Essential for activity (By similarity).
SQ   SEQUENCE   315 AA;  32562 MW;  EA769DB9CEFE73F0 CRC64;
     MARIAYLGPE GTFTEAALRQ ITAAGLVPGQ GADGVRPTPV DGTPAALDAV RDGAADYACV
     PIENSIDGSV TPTLDSLAIG SPLQVFAETT LDVAFSIVVK PGLSAADVRT LAAIGVAAAQ
     VRQWVAANLA GAQLRPAYSN ADAAQQVAEG RADAAVTSPL AAARWGLDTL ADGVVDEPNA
     RTRFVLVGPP APPPARTGAD RTSVVLRIDN APGALLAALA EFGIRGIDLT RIESRPTRTG
     LGIYRFFADC VGHIDDEPVA EALKALHRRC ADVRYLGSWP TGTPAGALPP STEEAVRWLA
     AVRDGKPEPP GESRR
//