GenomeNet

Database: UniProt
Entry: A0QHX0
LinkDB: A0QHX0
Original site: A0QHX0 
ID   COXX_MYCA1              Reviewed;         308 AA.
AC   A0QHX0;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 2.
DT   14-MAY-2014, entry version 51.
DE   RecName: Full=Protoheme IX farnesyltransferase;
DE            EC=2.5.1.-;
DE   AltName: Full=Heme B farnesyltransferase;
DE   AltName: Full=Heme O synthase;
GN   Name=ctaB; OrderedLocusNames=MAV_3326;
OS   Mycobacterium avium (strain 104).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC   Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=243243;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=104;
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Converts heme B (protoheme IX) to heme O by substitution
CC       of the vinyl group on carbon 2 of heme B porphyrin ring with a
CC       hydroxyethyl farnesyl side group (By similarity).
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; heme O
CC       biosynthesis; heme O from protoheme: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC       (Potential).
CC   -!- MISCELLANEOUS: Carbon 2 of the heme B porphyrin ring is defined
CC       according to the Fischer nomenclature (By similarity).
CC   -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
CC       Protoheme IX farnesyltransferase subfamily.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABK64550.1; Type=Erroneous initiation;
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP000479; ABK64550.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; YP_882508.1; NC_008595.1.
DR   STRING; 243243.MAV_3326; -.
DR   EnsemblBacteria; ABK64550; ABK64550; MAV_3326.
DR   GeneID; 4529178; -.
DR   KEGG; mav:MAV_3326; -.
DR   PATRIC; 17988339; VBIMycAvi38287_3254.
DR   eggNOG; COG0109; -.
DR   HOGENOM; HOG000237291; -.
DR   KO; K02301; -.
DR   OrthoDB; EOG6DVJQB; -.
DR   BioCyc; MAVI243243:GH3Y-3326-MONOMER; -.
DR   UniPathway; UPA00834; UER00712.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008495; F:protoheme IX farnesyltransferase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0048034; P:heme O biosynthetic process; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_00154; CyoE_CtaB; 1.
DR   InterPro; IPR006369; Protohaem_IX_farnesylTrfase.
DR   InterPro; IPR000537; UbiA_prenyltransferase.
DR   Pfam; PF01040; UbiA; 1.
DR   TIGRFAMs; TIGR01473; cyoE_ctaB; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Complete proteome; Heme biosynthesis; Membrane;
KW   Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN         1    308       Protoheme IX farnesyltransferase.
FT                                /FTId=PRO_0000327081.
FT   TRANSMEM     31     51       Helical; (Potential).
FT   TRANSMEM     53     73       Helical; (Potential).
FT   TRANSMEM    102    122       Helical; (Potential).
FT   TRANSMEM    124    144       Helical; (Potential).
FT   TRANSMEM    149    169       Helical; (Potential).
FT   TRANSMEM    170    190       Helical; (Potential).
FT   TRANSMEM    240    260       Helical; (Potential).
FT   TRANSMEM    288    308       Helical; (Potential).
SQ   SEQUENCE   308 AA;  33288 MW;  F0104B69FBCFEA58 CRC64;
     MSVRGRVAPS QTPSRIPGTV LAYLALTKPR VIELLLVTAI PAMLLAQRGT VNPLLIVNTL
     IGGMLAAGGA NALNCVADAD IDKVMKRTAR RPLARAAVPT RNALVFGLVL TAGSFLWLWW
     TTNLLSGLLA LATIAFYVFI YTLLLKRRTS QNVVWGGAAG CMPVMIGWSA VTGTIQWPAL
     VMFAIIFFWT PPHTWALAMR YKDDYKAAGV PMLPAVATER QVTKQILVYT WLTVLATLAL
     ALATGWLYAA VAVVAGVWFL AMAHQLYAGV RAGEPVKPLR LFLQSNNYLA VVFCALAIDS
     AIGLPHLF
//
DBGET integrated database retrieval system