ID COXX_MYCA1 Reviewed; 308 AA.
AC A0QHX0;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 2.
DT 01-MAY-2013, entry version 46.
DE RecName: Full=Protoheme IX farnesyltransferase;
DE EC=2.5.1.-;
DE AltName: Full=Heme B farnesyltransferase;
DE AltName: Full=Heme O synthase;
GN Name=ctaB; OrderedLocusNames=MAV_3326;
OS Mycobacterium avium (strain 104).
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC Mycobacterium avium complex (MAC).
OX NCBI_TaxID=243243;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=104;
RA Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA Fraser C.M.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Converts heme B (protoheme IX) to heme O by substitution
CC of the vinyl group on carbon 2 of heme B porphyrin ring with a
CC hydroxyethyl farnesyl side group (By similarity).
CC -!- PATHWAY: Porphyrin metabolism; heme O biosynthesis; heme O from
CC protoheme: step 1/1.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC (Potential).
CC -!- MISCELLANEOUS: Carbon 2 of the heme B porphyrin ring is defined
CC according to the Fischer nomenclature (By similarity).
CC -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
CC Protoheme IX farnesyltransferase subfamily.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABK64550.1; Type=Erroneous initiation;
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DR EMBL; CP000479; ABK64550.1; ALT_INIT; Genomic_DNA.
DR RefSeq; YP_882508.1; NC_008595.1.
DR STRING; 243243.MAV_3326; -.
DR EnsemblBacteria; ABK64550; ABK64550; MAV_3326.
DR GeneID; 4529178; -.
DR KEGG; mav:MAV_3326; -.
DR PATRIC; 17988339; VBIMycAvi38287_3254.
DR eggNOG; COG0109; -.
DR HOGENOM; HOG000237291; -.
DR KO; K02301; -.
DR ProtClustDB; PRK04375; -.
DR BioCyc; MAVI243243:GH3Y-3340-MONOMER; -.
DR UniPathway; UPA00834; UER00712.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008495; F:protoheme IX farnesyltransferase activity; IEA:HAMAP.
DR GO; GO:0048034; P:heme O biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_00154; CyoE_CtaB; 1; -.
DR InterPro; IPR006369; Protohaem_IX_farnesylTrfase.
DR InterPro; IPR000537; UbiA_prenyltransferase.
DR Pfam; PF01040; UbiA; 1.
DR TIGRFAMs; TIGR01473; cyoE_ctaB; 1.
DR PROSITE; PS00943; UBIA; FALSE_NEG.
PE 3: Inferred from homology;
KW Cell membrane; Complete proteome; Heme biosynthesis; Membrane;
KW Transferase; Transmembrane; Transmembrane helix.
FT CHAIN 1 308 Protoheme IX farnesyltransferase.
FT /FTId=PRO_0000327081.
FT TRANSMEM 31 51 Helical; (Potential).
FT TRANSMEM 53 73 Helical; (Potential).
FT TRANSMEM 102 122 Helical; (Potential).
FT TRANSMEM 124 144 Helical; (Potential).
FT TRANSMEM 149 169 Helical; (Potential).
FT TRANSMEM 170 190 Helical; (Potential).
FT TRANSMEM 240 260 Helical; (Potential).
FT TRANSMEM 288 308 Helical; (Potential).
SQ SEQUENCE 308 AA; 33288 MW; F0104B69FBCFEA58 CRC64;
MSVRGRVAPS QTPSRIPGTV LAYLALTKPR VIELLLVTAI PAMLLAQRGT VNPLLIVNTL
IGGMLAAGGA NALNCVADAD IDKVMKRTAR RPLARAAVPT RNALVFGLVL TAGSFLWLWW
TTNLLSGLLA LATIAFYVFI YTLLLKRRTS QNVVWGGAAG CMPVMIGWSA VTGTIQWPAL
VMFAIIFFWT PPHTWALAMR YKDDYKAAGV PMLPAVATER QVTKQILVYT WLTVLATLAL
ALATGWLYAA VAVVAGVWFL AMAHQLYAGV RAGEPVKPLR LFLQSNNYLA VVFCALAIDS
AIGLPHLF
//
