ID A0QNF4_MYCS2 Unreviewed; 440 AA.
AC A0QNF4;
DT 09-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 109.
DE RecName: Full=L-lysine N6-monooxygenase MbtG {ECO:0000256|ARBA:ARBA00016406};
DE EC=1.14.13.59 {ECO:0000256|ARBA:ARBA00013076};
DE AltName: Full=Lysine 6-N-hydroxylase {ECO:0000256|ARBA:ARBA00032738};
DE AltName: Full=Lysine N6-hydroxylase {ECO:0000256|ARBA:ARBA00032493};
DE AltName: Full=Lysine-N-oxygenase {ECO:0000256|ARBA:ARBA00029939};
DE AltName: Full=Mycobactin synthase protein G {ECO:0000256|ARBA:ARBA00031158};
GN OrderedLocusNames=MSMEG_0022 {ECO:0000313|EMBL:ABK73576.1};
OS Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS smegmatis).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=246196 {ECO:0000313|EMBL:ABK73576.1, ECO:0000313|Proteomes:UP000000757};
RN [1] {ECO:0000313|EMBL:ABK73576.1, ECO:0000313|Proteomes:UP000000757}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155 {ECO:0000313|Proteomes:UP000000757};
RA Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA Fraser C.M.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+);
CC Xref=Rhea:RHEA:23228, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:32551, ChEBI:CHEBI:57783, ChEBI:CHEBI:57820,
CC ChEBI:CHEBI:58349; EC=1.14.13.59;
CC Evidence={ECO:0000256|ARBA:ARBA00000168};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Siderophore biosynthesis; mycobactin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005102}.
CC -!- SIMILARITY: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-
CC oxygenase family. {ECO:0000256|ARBA:ARBA00007588}.
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DR EMBL; CP000480; ABK73576.1; -; Genomic_DNA.
DR RefSeq; WP_011726614.1; NZ_SIJM01000001.1.
DR RefSeq; YP_884442.1; NC_008596.1.
DR AlphaFoldDB; A0QNF4; -.
DR STRING; 246196.MSMEG_0022; -.
DR PaxDb; 246196-MSMEI_0024; -.
DR GeneID; 66738213; -.
DR KEGG; msm:MSMEG_0022; -.
DR PATRIC; fig|246196.19.peg.20; -.
DR eggNOG; COG3486; Bacteria.
DR OrthoDB; 7527071at2; -.
DR Proteomes; UP000000757; Chromosome.
DR GO; GO:0047091; F:L-lysine 6-monooxygenase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR025700; Lys/Orn_oxygenase.
DR PANTHER; PTHR42802:SF1; L-ORNITHINE N(5)-MONOOXYGENASE; 1.
DR PANTHER; PTHR42802; MONOOXYGENASE; 1.
DR Pfam; PF13434; Lys_Orn_oxgnase; 1.
DR PRINTS; PR00368; FADPNR.
DR PRINTS; PR00411; PNDRDTASEI.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000757}.
SQ SEQUENCE 440 AA; 48507 MW; FC3EB64324C0BDA6 CRC64;
MQSIDHLNGR NGDSPVLDVV GVGFGPSNLA LAIAIREYNE THAEAINAEF VEVKPEFGWH
TGMLIPGATM QVSFLKDLAT QRNPTSEFTF LNYLTERRRL TEFINFKTFF PTRLEFHDYL
SWAADKVGAT VHYGSRVVSV RDTDGAFDVT VTGATEGILR ARNVVVAGGL QPLLPPGVQR
TRRQIHNHGL LHDLAAMPDP RHNRYVVVGA GQSAAEVCAY LHDLSPDNEV HGVFAKYGYS
PADDSPFANR VFDPDAVDDF FVADPAVRRR LINYHRSTNY SAVDLELIEE LYAREYAERV
AGRRRLFVRG ASSVQHTDED DAGVRVHIRH HPSGTVEELD CDAVIYATGF MPARLDGILG
DLYHDLVLED GNPVVSRDYR LATVPPTAGG LYIQGNTEHT HGLTSSLLSN IAVRSGEILE
SVITHTRTGT HRLSPVGSDA
//
