ID LPQB_MYCS2 Reviewed; 585 AA.
AC A0QTK4; I7G6N1;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 1.
DT 01-MAY-2013, entry version 43.
DE RecName: Full=Lipoprotein LpqB;
DE Flags: Precursor;
GN Name=lpqB; OrderedLocusNames=MSMEG_1876, MSMEI_1837;
OS Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155).
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Corynebacterineae; Mycobacteriaceae; Mycobacterium.
OX NCBI_TaxID=246196;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155;
RA Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA Fraser C.M.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155;
RX PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20;
RA Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C.,
RA Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.;
RT "Interrupted coding sequences in Mycobacterium smegmatis: authentic
RT mutations or sequencing errors?";
RL Genome Biol. 8:R20.1-R20.9(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155;
RX PubMed=18955433; DOI=10.1101/gr.081901.108;
RA Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M.,
RA Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.;
RT "Ortho-proteogenomics: multiple proteomes investigation through
RT orthology and a new MS-based protocol.";
RL Genome Res. 19:128-135(2009).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RC STRAIN=ATCC 700084 / mc(2)155;
RX PubMed=20233304; DOI=10.1111/j.1365-2958.2010.07110.x;
RA Nguyen H.T., Wolff K.A., Cartabuke R.H., Ogwang S., Nguyen L.;
RT "A lipoprotein modulates activity of the MtrAB two-component system to
RT provide intrinsic multidrug resistance, cytokinetic control and cell
RT wall homeostasis in Mycobacterium.";
RL Mol. Microbiol. 76:348-364(2010).
CC -!- FUNCTION: May modulate activity of the MtrAB system in controlling
CC homeostasis of the cell wall and cell division.
CC -!- SUBUNIT: Interacts with MtrB, probably extracytoplasmically via
CC its sensor domain.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor (Probable).
CC Secreted, cell wall.
CC -!- DISRUPTION PHENOTYPE: Increased antibiotic susceptibility, altered
CC colony morphology and increased aggregation, increased uptake of
CC the Congo Red stain and increased sensitivity to SDS. Decreased
CC gliding motility and biofilm formation. Cells are very long,
CC sometimes branched and often polyploid. Decreased phosphorylation
CC of MtrA, increased expression of dnaA in early growth stages.
CC -!- SIMILARITY: Belongs to the LpqB lipoprotein family.
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DR EMBL; CP000480; ABK72170.1; -; Genomic_DNA.
DR EMBL; CP001663; AFP38309.1; -; Genomic_DNA.
DR RefSeq; YP_006566604.1; NC_018289.1.
DR RefSeq; YP_886242.1; NC_008596.1.
DR ProteinModelPortal; A0QTK4; -.
DR STRING; 246196.MSMEG_1876; -.
DR EnsemblBacteria; ABK72170; ABK72170; MSMEG_1876.
DR GeneID; 13428354; -.
DR GeneID; 4533110; -.
DR KEGG; msg:MSMEI_1837; -.
DR KEGG; msm:MSMEG_1876; -.
DR PATRIC; 18076203; VBIMycSme59918_1858.
DR eggNOG; NOG05516; -.
DR HOGENOM; HOG000221001; -.
DR OMA; YWREVPG; -.
DR ProtClustDB; PRK13616; -.
DR BioCyc; MSME246196:GJ4Y-1876-MONOMER; -.
DR GO; GO:0005618; C:cell wall; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR HAMAP; MF_01373; LpqB_lipoprot; 1; -.
DR InterPro; IPR019606; GerMN.
DR InterPro; IPR023959; Lipoprotein_LpqB.
DR InterPro; IPR018910; Lipoprotein_LpqB_C.
DR Pfam; PF10646; Germane; 1.
DR Pfam; PF10647; Gmad1; 1.
DR SMART; SM00909; Germane; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cell wall; Complete proteome; Lipoprotein; Membrane;
KW Palmitate; Reference proteome; Secreted; Signal.
FT SIGNAL 1 18 Potential.
FT CHAIN 19 585 Lipoprotein LpqB.
FT /FTId=PRO_0000286723.
FT LIPID 19 19 N-palmitoyl cysteine (Potential).
FT LIPID 19 19 S-diacylglycerol cysteine (Potential).
SQ SEQUENCE 585 AA; 61398 MW; 01C54E2CDDED1C37 CRC64;
MKRLLTVLVV GLVALVSGCA GIPSSSSPQA IGTVERPAPP SLPKPTPDMD PDVLLREFLK
ATADPANRHL AARQFLTESA SSAWDDAGSA LLIDRVVFVE TRSTDRVSVS MRADILGSLS
DLGVFETGEG ALPDPGPIEL VKTSGGWRID RLPNGVFLDW QQFQATYKRY TLYFVDPTGT
TVVPDPRYVA VSDPDQLATE LVSKLIAGPR PEMERSVRNL LDPPLKLRGP VTRADGGKTG
VGRGYGGARI DLENLSASDP HSRQLLAAQL IWTLSRAGVA GPYVINVDGA PLDDRFADGW
ETSDVAATDP GAAPGAAAGL HALVNGSLVS LDGQRAPRVP GAFGQAPHQV SASVSRNGQD
AASVVAPPGA PDPAATLWIG PLGGSTVQAM EGRTLSRPSW SLDQAVWVVA DGINVVRAIR
DASGTPARIP VDSSAVSSRY PGPISDLQLS RDGTRAAMVI EGQVILAGIE QTQDGRFLLT
YPRRLGFGLG NSAVSLSWRT GDDIVVSRTD PEHPVSYVNL DGVNSDAPSR NLVMPVSVVA
ANPSTVYVAD QRGVKQLSAS ADEENSGWVE VSPLMVPGSL PVLPG
//
