ID A0QTQ5_MYCS2 Unreviewed; 265 AA.
AC A0QTQ5;
DT 09-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE SubName: Full=Cobyrinic Acid a,c-diamide synthase {ECO:0000313|EMBL:ABK69693.1};
GN OrderedLocusNames=MSMEG_1927 {ECO:0000313|EMBL:ABK69693.1};
OS Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS smegmatis).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=246196 {ECO:0000313|EMBL:ABK69693.1, ECO:0000313|Proteomes:UP000000757};
RN [1] {ECO:0000313|EMBL:ABK69693.1, ECO:0000313|Proteomes:UP000000757}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155 {ECO:0000313|Proteomes:UP000000757};
RA Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA Fraser C.M.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0007829|PDB:4PFS}
RP X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS).
RA Davies D.R., Fairman J., Abendroth J.;
RT "Crystal Structure of Cobyrinic Acid a,c-diamide synthase from
RT Mycobacterium smegmatis.";
RL Submitted (APR-2014) to the PDB data bank.
RN [3] {ECO:0007829|PDB:5IHP}
RP X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) IN COMPLEX WITH ADP AND MG(2+).
RA Davies D.R., Horanyi P.S., Abendroth J.A., SSGCID.;
RT "Crystal Structure of Cobyrinic Acid a,c-diamide synthase from
RT Mycobacterium smegmatis with bound ATP analog and Magnesium.";
RL Submitted (FEB-2016) to the PDB data bank.
RN [4] {ECO:0007829|PDB:5IF9}
RP X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 2-265 IN COMPLEX WITH ATP ANALOG.
RA Davies D.R., Dranow D.M., Abendroth J.A., SSGCID.;
RT "Crystal Structure of Cobyrinic Acid a,c-diamide synthase from
RT Mycobacterium smegmatis with bound ATP analog and Magnesium.";
RL Submitted (FEB-2016) to the PDB data bank.
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DR EMBL; CP000480; ABK69693.1; -; Genomic_DNA.
DR RefSeq; WP_011728017.1; NZ_SIJM01000020.1.
DR RefSeq; YP_886293.1; NC_008596.1.
DR PDB; 4PFS; X-ray; 2.30 A; A/B=1-265.
DR PDB; 5IF9; X-ray; 1.80 A; A/B=2-265.
DR PDB; 5IHP; X-ray; 1.85 A; A/B=1-265.
DR PDBsum; 4PFS; -.
DR PDBsum; 5IF9; -.
DR PDBsum; 5IHP; -.
DR AlphaFoldDB; A0QTQ5; -.
DR SMR; A0QTQ5; -.
DR STRING; 246196.MSMEG_1927; -.
DR PaxDb; 246196-MSMEI_1886; -.
DR GeneID; 66733361; -.
DR KEGG; msm:MSMEG_1927; -.
DR PATRIC; fig|246196.19.peg.1908; -.
DR eggNOG; COG1192; Bacteria.
DR OrthoDB; 9815116at2; -.
DR Proteomes; UP000000757; Chromosome.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR CDD; cd02042; ParAB_family; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13696; P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE; 1.
DR PANTHER; PTHR13696:SF90; POSSIBLE SOJ_PARA-RELATED PROTEIN; 1.
DR Pfam; PF13614; AAA_31; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:4PFS, ECO:0007829|PDB:5IF9};
KW Metal-binding {ECO:0007829|PDB:5IF9, ECO:0007829|PDB:5IHP};
KW Nucleotide-binding {ECO:0007829|PDB:5IHP};
KW Reference proteome {ECO:0000313|Proteomes:UP000000757}.
FT DOMAIN 3..176
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
FT BINDING 13
FT /ligand="ADP"
FT /ligand_id="ChEBI:CHEBI:456216"
FT /evidence="ECO:0007829|PDB:5IHP"
FT BINDING 14
FT /ligand="ADP"
FT /ligand_id="ChEBI:CHEBI:456216"
FT /evidence="ECO:0007829|PDB:5IHP"
FT BINDING 15
FT /ligand="ADP"
FT /ligand_id="ChEBI:CHEBI:456216"
FT /evidence="ECO:0007829|PDB:5IHP"
FT BINDING 16
FT /ligand="ADP"
FT /ligand_id="ChEBI:CHEBI:456216"
FT /evidence="ECO:0007829|PDB:5IHP"
FT BINDING 17
FT /ligand="ADP"
FT /ligand_id="ChEBI:CHEBI:456216"
FT /evidence="ECO:0007829|PDB:5IHP"
FT BINDING 17
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0007829|PDB:5IF9, ECO:0007829|PDB:5IHP"
FT BINDING 18
FT /ligand="ADP"
FT /ligand_id="ChEBI:CHEBI:456216"
FT /evidence="ECO:0007829|PDB:5IHP"
FT BINDING 213
FT /ligand="ADP"
FT /ligand_id="ChEBI:CHEBI:456216"
FT /evidence="ECO:0007829|PDB:5IHP"
FT BINDING 215
FT /ligand="ADP"
FT /ligand_id="ChEBI:CHEBI:456216"
FT /evidence="ECO:0007829|PDB:5IHP"
SQ SEQUENCE 265 AA; 28346 MW; 4D7040DBE098A0B7 CRC64;
MTRVLAVANQ KGGVAKTTTV ASIGAALTEQ GRRVLLVDLD PQGCLTFSLG HDPDKLPVSV
HEVLLGDVEP SAALVRTDEG MTLLPANIDL AGAEAMLLMR AGREYALKRA LAKLDGDFDV
VIIDCPPSLG VLTLNGLTAA HDVIVPLQCE TLAHRGVGQF LRTISDVQQI TNPDLKLLGA
LPTLYDSRTT HSRDVLLDVA DRYELPVLAP PIPRTVRFAE ASASGSSVLA GRKSKGAIAY
REFADALLRH WKSGRKMPTF TPEVV
//
