ID A0QY12_MYCS2 Unreviewed; 969 AA.
AC A0QY12;
DT 09-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 109.
DE SubName: Full=MmpL4 protein {ECO:0000313|EMBL:ABK70117.1};
GN OrderedLocusNames=MSMEG_3496 {ECO:0000313|EMBL:ABK70117.1};
OS Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS smegmatis).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=246196 {ECO:0000313|EMBL:ABK70117.1, ECO:0000313|Proteomes:UP000000757};
RN [1] {ECO:0000313|EMBL:ABK70117.1, ECO:0000313|Proteomes:UP000000757}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155 {ECO:0000313|Proteomes:UP000000757};
RA Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA Fraser C.M.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR EMBL; CP000480; ABK70117.1; -; Genomic_DNA.
DR RefSeq; WP_011729110.1; NZ_SIJM01000039.1.
DR RefSeq; YP_887800.1; NC_008596.1.
DR AlphaFoldDB; A0QY12; -.
DR STRING; 246196.MSMEG_3496; -.
DR PaxDb; 246196-MSMEI_3416; -.
DR KEGG; msm:MSMEG_3496; -.
DR PATRIC; fig|246196.19.peg.3452; -.
DR eggNOG; COG2409; Bacteria.
DR OrthoDB; 4656631at2; -.
DR Proteomes; UP000000757; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR004707; MmpL_fam.
DR NCBIfam; TIGR00833; actII; 1.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000757};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 212..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 257..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 778..797
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 804..829
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 835..857
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 878..898
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 904..927
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 65..395
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 617..951
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
SQ SEQUENCE 969 AA; 106208 MW; AFBF05F118AB008F CRC64;
MSNPSHDAPT DAMGVSGPKH ARPGGIAKWI RVLAVPIILV WVAIIAVLNT VVPQLDVVGE
MRSVSMSPDD APSVIAMKRV GEVFEEFKSN SSVMIVLEGE QPLGDEAHKY YDEIVDKLEA
DPAHVEHVQD FWGDPLTASG AQSPDGLASY VQVYTRGNQG EALANESVEA VQDIVESVPA
PPGVKAYVTG PAALSADQHV ASDRSVRVIE ALTFAVIITM LLLVYRSIVT VILTLVMVVL
SLSAARGMIA FLGYHEIIGL SVFATNLLTT LAIAAATDYA IFLIGRYQEA RSVGEDREQS
YYTMFHSTAH VVLGSGMTIA GATLCLHFTR MPYFQSLGIP LAIGMSVVVL ASLTMGAAII
SVASRFGKTF EPKRAMRTRG WRKLGAAVVR WPAPILVTTI ALSVVGLLAL PGYQTNYNDR
RYLPQDLPAN TGYAAADRHF SQARMNPELL MIESDHDLRN SADFLVVDRI AKRVFQVPGI
SRVQAITRPQ GTPIEHTSIP FQISMSGTTQ MMNMKYMQDR MADMLVMADE MQKSVDTMEE
MLKITREMSD TTHSMVGKMH GMVEDIKELR DHIADFDDFL RPIRNYFYWE PHCDSIPVCQ
SIRSIFDTLD GIDVMTDDIQ RLMPDMDRLD ELMPQMLTIM PPMIESMKTM KTMMLTTQAT
MGGLQDQMEA AMENQTAMGQ AFDASKNDDS FYLPPETFEN PDFKRGMKMF LSPDGHAVRF
IISHEGDPMS PEGIKHIDAI KQAAKEAIKG TPLEGSKIYL GGTAATFKDL QEGANYDLII
AGIAALCLIF IIMLIITRAV VASAVIVGTV VISLGASFGL SVLIWQHIIG LELHWMVLAM
AVIVLLAVGA DYNLLLVSRI KEEIHAGLNT GIIRSMGGTG SVVTSAGLVF AFTMMSMAVS
ELAVIAQVGT TIGLGLLFDT LVIRSFMTPS IAALMGKWFW WPQRVRQRPL PAPWPQPVQR
DPEDALNRV
//
