ID A0QY99_MYCS2 Unreviewed; 959 AA.
AC A0QY99;
DT 09-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE SubName: Full=Membrane protein, MmpL family protein {ECO:0000313|EMBL:ABK73423.1};
GN OrderedLocusNames=MSMEG_3584 {ECO:0000313|EMBL:ABK73423.1};
OS Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS smegmatis).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=246196 {ECO:0000313|EMBL:ABK73423.1, ECO:0000313|Proteomes:UP000000757};
RN [1] {ECO:0000313|EMBL:ABK73423.1, ECO:0000313|Proteomes:UP000000757}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155 {ECO:0000313|Proteomes:UP000000757};
RA Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA Fraser C.M.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR EMBL; CP000480; ABK73423.1; -; Genomic_DNA.
DR RefSeq; WP_011729180.1; NZ_SIJM01000008.1.
DR RefSeq; YP_887887.1; NC_008596.1.
DR AlphaFoldDB; A0QY99; -.
DR STRING; 246196.MSMEG_3584; -.
DR PaxDb; 246196-MSMEI_3503; -.
DR GeneID; 66734972; -.
DR KEGG; msm:MSMEG_3584; -.
DR PATRIC; fig|246196.19.peg.3535; -.
DR eggNOG; COG2409; Bacteria.
DR OrthoDB; 2365435at2; -.
DR Proteomes; UP000000757; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR004707; MmpL_fam.
DR NCBIfam; TIGR00833; actII; 1.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000757};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 254..278
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 385..403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 768..786
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 793..815
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 821..840
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 861..882
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 915..931
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 58..385
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 612..940
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
SQ SEQUENCE 959 AA; 104199 MW; D63763483FCBA652 CRC64;
MPGQVGMSAH RAGRPFFARA VRVLALPIVA FWILVTIGTN IFVPQAEKVA DELAGPMIPT
YAPSQVALLQ MGEKFGESDS TNLTMLVLEA DRPLDDADHR FYDDLVRRLQ SDPAHVQYVM
DLWGEPITAA AVQSVDGKAA FVMLRLAGNT GKLEANESVD AVRDIVAADA PPPGLKVYVS
GPAPLASDTL TIATASLKNI TILTIILIVA MLLLVYRSVP SLLVPLPAVL IELLAAKGVV
AVLGHLGVIP LSSFAVNLLV ALTLGAGTDY GIFMLGRYQE ARRAGESREE AYFTAYRSVA
PIIIGSGLTI AGACFCLSLA RLDYFHTMGP AVAVSMLCTI AAALTLAPAL LTLGSRRGLF
DPRRLNSGRL YRHIATSVVR WPKPVFVASA VVVLVGAVFV PTYQVGYDDR AYQPADAPAK
LGFEAADRHF PQSKLMSELL MVESDHDMRN SADFISLDRA AKSLIRLPGV AMVQSITRPL
GRPLEHATIP YLFTMQGSTS GQQLPFDQQL NENTDRQADI QAHSLQVIQQ VISITTQMSD
ELHATTVTFE NLKEVTDEVN EGISDLDDFL RPLKNYFYWE PHCFDIPVCF AIRSLFDSLD
GIDRLDEQIG NAVESFEAID RLLPQMITQL EQMKIAGKAT LSLLQNNYGS AHLQSTQTDQ
TYDDLINVGN DFDAARSDDF FYIPHEAFDN DDVKTGMKLL MSPDGKAARF IITHEGNAMA
QEGIEHVEQI PDAIKMALKE TSLAGAKVYL GGAASSTKDI QDYAASDLLI VAIAAFVLIF
LIMLYLTRSL VAAMVIPGTV AFSFAGAFGL SVLVWQHLIG LPLHWLVLPL AFIILVAVGS
DYNLLLISRV KEESGAGLNT ALIRALGSTG AVVTSAGLVF AFTMLSMLAS NLAAVGQLGS
TVCIGLLLDT MIVRSLVVPC LLRLLGPWFW WPTFIRQRPL RTPDRFARPG PSRRIMTDR
//
