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Database: UniProt
Entry: A0QZB5_MYCS2
LinkDB: A0QZB5_MYCS2
Original site: A0QZB5_MYCS2 
ID   A0QZB5_MYCS2            Unreviewed;       576 AA.
AC   A0QZB5;
DT   09-JAN-2007, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2007, sequence version 1.
DT   27-SEP-2017, entry version 85.
DE   SubName: Full=Pyruvate dehydrogenase {ECO:0000313|EMBL:ABK75384.1};
GN   OrderedLocusNames=MSMEG_3964 {ECO:0000313|EMBL:ABK75384.1};
OS   Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=246196 {ECO:0000313|EMBL:ABK75384.1, ECO:0000313|Proteomes:UP000000757};
RN   [1] {ECO:0000313|EMBL:ABK75384.1, ECO:0000313|Proteomes:UP000000757}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155 {ECO:0000313|Proteomes:UP000000757};
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|RuleBase:RU362132}.
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DR   EMBL; CP000480; ABK75384.1; -; Genomic_DNA.
DR   RefSeq; WP_011729435.1; NZ_CP009494.1.
DR   RefSeq; YP_888253.1; NC_008596.1.
DR   STRING; 246196.MSMEG_3964; -.
DR   EnsemblBacteria; ABK75384; ABK75384; MSMEG_3964.
DR   EnsemblBacteria; AFP40329; AFP40329; MSMEI_3871.
DR   GeneID; 4533318; -.
DR   KEGG; msb:LJ00_19695; -.
DR   KEGG; msm:MSMEG_3964; -.
DR   PATRIC; fig|246196.19.peg.3903; -.
DR   eggNOG; ENOG4105C7K; Bacteria.
DR   eggNOG; COG0028; LUCA.
DR   HOGENOM; HOG000258444; -.
DR   KO; K00156; -.
DR   OMA; DRNAFQD; -.
DR   OrthoDB; POG091H02KO; -.
DR   Proteomes; UP000000757; Chromosome.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   Gene3D; 3.40.50.1220; -; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR000399; TPP-bd_CS.
DR   InterPro; IPR011766; TPP_enzyme-bd_C.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   PROSITE; PS00187; TPP_ENZYMES; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000757};
KW   Pyruvate {ECO:0000313|EMBL:ABK75384.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000757};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
SQ   SEQUENCE   576 AA;  62005 MW;  041656A41D196AFC CRC64;
     MITVADHIVS VLRISGVRRV YGLPGDSLNG FTDAIRRSGE ISWEHVRHEE TAAFAAAADA
     GLTGQLAVCA GSCGPGNLHL INGLFDAQRS RVPVLAIAAH IPRSEIGSQY FQETHPQELF
     GECSVYCELV STPEMAPRIL AMAMRAAVED NGVAVVVIPG EIFLQRIPEQ PVRPISATRS
     VLCPDEASLQ RAADMLNAAE RVTILGGAGV AGAHDALVQL AATLQAPVVH ALRGKEFIEY
     DNPFDVGMTG LLGFASGYKA IKEADTLLML GTDFPYQQFY PENATVIQVD VRGAHLGRRT
     PIDLGLRGTV GDTLAALQPL LRPKHDREHL DRALRHYRKT RASLDALAVN DRDRTPIRPE
     YLAGLIDRLA AADAVFTCDV GSPVVWAARY LSMNGRRRLL GSFNHGTMAN ALPHAIGAQS
     AYPGRQVIAL AGDGGLTMLF GELVTLIQNR LPVKVIVFNN SSLNFVELEM KAAGIVTFGT
     DLQNPDFAAV ATAMGIHGRK VTEPADLEDV LKEAFAHDGP AVIDVHTARQ ELSIPPAITI
     EQAKGFSLYA IRTILAGRSD ELLDLITTNV ARRILD
//
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