ID A0R3H1_MYCS2 Unreviewed; 298 AA.
AC A0R3H1;
DT 09-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=UTP--glucose-1-phosphate uridylyltransferase {ECO:0000256|ARBA:ARBA00012415};
DE EC=2.7.7.9 {ECO:0000256|ARBA:ARBA00012415};
GN Name=galU {ECO:0000313|EMBL:ABK73209.1};
GN OrderedLocusNames=MSMEG_5471 {ECO:0000313|EMBL:ABK73209.1};
OS Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS smegmatis).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=246196 {ECO:0000313|EMBL:ABK73209.1, ECO:0000313|Proteomes:UP000000757};
RN [1] {ECO:0000313|EMBL:ABK73209.1, ECO:0000313|Proteomes:UP000000757}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155 {ECO:0000313|Proteomes:UP000000757};
RA Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA Fraser C.M.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-
CC alpha-D-glucose; Xref=Rhea:RHEA:19889, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:58601,
CC ChEBI:CHEBI:58885; EC=2.7.7.9;
CC Evidence={ECO:0000256|ARBA:ARBA00000872};
CC -!- SIMILARITY: Belongs to the UDPGP type 2 family.
CC {ECO:0000256|ARBA:ARBA00006890}.
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DR EMBL; CP000480; ABK73209.1; -; Genomic_DNA.
DR RefSeq; YP_889709.1; NC_008596.1.
DR AlphaFoldDB; A0R3H1; -.
DR STRING; 246196.MSMEG_5471; -.
DR PaxDb; 246196-MSMEI_5321; -.
DR KEGG; msm:MSMEG_5471; -.
DR PATRIC; fig|246196.19.peg.5330; -.
DR eggNOG; COG1210; Bacteria.
DR OrthoDB; 9803306at2; -.
DR Proteomes; UP000000757; Chromosome.
DR GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR InterPro; IPR005771; GalU_uridylyltTrfase_bac/arc.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR43197; UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR PANTHER; PTHR43197:SF1; UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Nucleotidyltransferase {ECO:0000313|EMBL:ABK73209.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000757};
KW Transferase {ECO:0000313|EMBL:ABK73209.1}.
FT DOMAIN 7..273
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
SQ SEQUENCE 298 AA; 31686 MW; 2716AE5F601CF8CA CRC64;
MSIPHTAVVP AAGLGTRFLP ATKTVPKELL PVVDTPGIEL VAAEAAEAGA ERLVIVTSEG
KDGVVAHFVQ DLVLEGTLEA RGKKTMLEKV RRAPALIKVE SVVQAEPLGL GHAVSCVESV
LAADEDAISV LLPDDLVLPT GVLETMSKVR AKRGGSVLCA IEVPGDKISA YGVFDVETVP
DAANPNVLRV KGMVEKPRPE DAPSHFAAAG RYVLDRAIFD ALRRVPRGTG GEIQLTDAIA
LLIEEDHPVH VVVHRGARHD LGNPGGYLKA AVDFALERDD YGPELRQWLV ERLGLAEK
//
