ID A0R5U1_MYCS2 Unreviewed; 405 AA.
AC A0R5U1;
DT 09-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE SubName: Full=Saccharopine dehydrogenase {ECO:0000313|EMBL:ABK75440.1};
DE EC=1.5.1.7 {ECO:0000313|EMBL:ABK75440.1};
GN Name=lys1 {ECO:0000313|EMBL:ABK75440.1};
GN OrderedLocusNames=MSMEG_6311 {ECO:0000313|EMBL:ABK75440.1};
OS Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS smegmatis).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=246196 {ECO:0000313|EMBL:ABK75440.1, ECO:0000313|Proteomes:UP000000757};
RN [1] {ECO:0000313|EMBL:ABK75440.1, ECO:0000313|Proteomes:UP000000757}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155 {ECO:0000313|Proteomes:UP000000757};
RA Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA Fraser C.M.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the saccharopine dehydrogenase family. Enoyl
CC reductase subfamily. {ECO:0000256|ARBA:ARBA00010591}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000480; ABK75440.1; -; Genomic_DNA.
DR RefSeq; WP_011731196.1; NZ_SIJM01000013.1.
DR RefSeq; YP_890529.1; NC_008596.1.
DR AlphaFoldDB; A0R5U1; -.
DR STRING; 246196.MSMEG_6311; -.
DR PaxDb; 246196-MSMEI_6145; -.
DR GeneID; 66737592; -.
DR KEGG; msm:MSMEG_6311; -.
DR PATRIC; fig|246196.19.peg.6146; -.
DR eggNOG; COG1748; Bacteria.
DR OrthoDB; 9769367at2; -.
DR Proteomes; UP000000757; Chromosome.
DR GO; GO:0004754; F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032095; Sacchrp_dh-like_C.
DR InterPro; IPR005097; Sacchrp_dh_NADP.
DR PANTHER; PTHR43796; CARBOXYNORSPERMIDINE SYNTHASE; 1.
DR PANTHER; PTHR43796:SF2; CARBOXYNORSPERMIDINE SYNTHASE; 1.
DR Pfam; PF16653; Sacchrp_dh_C; 1.
DR Pfam; PF03435; Sacchrp_dh_NADP; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000313|EMBL:ABK75440.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000757}.
FT DOMAIN 3..139
FT /note="Saccharopine dehydrogenase NADP binding"
FT /evidence="ECO:0000259|Pfam:PF03435"
FT DOMAIN 144..397
FT /note="Saccharopine dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16653"
SQ SEQUENCE 405 AA; 43963 MW; 14F875D61A84F955 CRC64;
MRILLVGAGG VGSAFCAIAA RRNFFDQIVV CDYDESRARQ AAEAVGDARF TSAQVDATSA
DAVADLVREH QITHVMNAVD PRFVMPIFNG ALAGGADYLD MAMSLSRRHP DRPYELTGVK
LGDEQFGAAE DWEAAGRLAL VGIGVEPGLS DVFARYAADH LFSEIDELGT RDGSSLVVEG
CDFAPSFSIW TTIEECLNPP VVWEADRGWF VTEPFSEPEV FDFPEGIGPV ECVNVEHEEV
LLMPRWVKCK RATFKYGLGS EFIDVLKTLH KLGLDRTDKV RVPGANGPVE VSPRDVVAAC
LPNPATLGPQ MHGKTCAGLW VTGKGKDGAP RSTYLYHVVD NQWSMAEYGH QCVVWQTAIN
PVVALELLAS GMWSGAGVLG PEAFDAVPFL NLLKDYGSPW GIKEL
//
