ID A0XYE3_9GAMM Unreviewed; 204 AA.
AC A0XYE3;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=HTH-type transcriptional regulator BetI {ECO:0000256|HAMAP-Rule:MF_00768};
GN Name=betI {ECO:0000256|HAMAP-Rule:MF_00768};
GN ORFNames=ATW7_03162 {ECO:0000313|EMBL:EAW29084.1};
OS Alteromonadales bacterium TW-7.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales.
OX NCBI_TaxID=156578 {ECO:0000313|EMBL:EAW29084.1, ECO:0000313|Proteomes:UP000004833};
RN [1] {ECO:0000313|EMBL:EAW29084.1, ECO:0000313|Proteomes:UP000004833}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW-7 {ECO:0000313|EMBL:EAW29084.1,
RC ECO:0000313|Proteomes:UP000004833};
RA Azam F., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G.,
RA Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Repressor involved in choline regulation of the bet genes.
CC {ECO:0000256|HAMAP-Rule:MF_00768}.
CC -!- FUNCTION: Repressor involved in the biosynthesis of the osmoprotectant
CC glycine betaine. It represses transcription of the choline transporter
CC BetT and the genes of BetAB involved in the synthesis of glycine
CC betaine. {ECO:0000256|ARBA:ARBA00024936}.
CC -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via
CC choline pathway [regulation]. {ECO:0000256|ARBA:ARBA00004719,
CC ECO:0000256|HAMAP-Rule:MF_00768}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAW29084.1}.
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DR EMBL; AAVS01000003; EAW29084.1; -; Genomic_DNA.
DR AlphaFoldDB; A0XYE3; -.
DR eggNOG; COG1309; Bacteria.
DR UniPathway; UPA00529; -.
DR Proteomes; UP000004833; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR HAMAP; MF_00768; HTH_type_BetI; 1.
DR InterPro; IPR039538; BetI_C.
DR InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR InterPro; IPR017757; Tscrpt_rep_BetI.
DR NCBIfam; TIGR03384; betaine_BetI; 1.
DR PANTHER; PTHR43479; ACREF/ENVCD OPERON REPRESSOR-RELATED; 1.
DR Pfam; PF13977; TetR_C_6; 1.
DR Pfam; PF00440; TetR_N; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF48498; Tetracyclin repressor-like, C-terminal domain; 1.
DR PROSITE; PS01081; HTH_TETR_1; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_00768, ECO:0000256|PROSITE-
KW ProRule:PRU00335};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00768};
KW Transcription {ECO:0000256|HAMAP-Rule:MF_00768};
KW Transcription regulation {ECO:0000256|HAMAP-Rule:MF_00768}.
FT DOMAIN 16..76
FT /note="HTH tetR-type"
FT /evidence="ECO:0000259|PROSITE:PS50977"
FT DNA_BIND 39..58
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00768,
FT ECO:0000256|PROSITE-ProRule:PRU00335"
SQ SEQUENCE 204 AA; 22919 MW; C0CBF5FCED477FCB CRC64;
MNVQLIKIMP KVGMEPVRRQ QLIDATIESV AMRGLQATTI NSISKNAGLS SGIISHYFGG
KQGLIEATVR YLLSNLKKDL IEKVCNNTSA TQRLMFIVEA NFALVQQRSD TTKTWLSFWA
QSMHDDELHR LQNVNSKRLQ SNLAFSFKQL MPIEQAKQAA ELSAAMIDGL WLRAVLSKSD
KNQFKHSETL AKSYVNSLIK QYGA
//
