ID A0ZCD4_NODSP Unreviewed; 462 AA.
AC A0ZCD4;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=Phthiocerol/phthiodiolone dimycocerosyl transferase {ECO:0000256|ARBA:ARBA00013449};
DE EC=2.3.1.282 {ECO:0000256|ARBA:ARBA00012866};
DE AltName: Full=Acyltransferase PapA5 {ECO:0000256|ARBA:ARBA00033407};
DE AltName: Full=Phthiocerol/phthiodiolone O-acyltransferase {ECO:0000256|ARBA:ARBA00030465};
DE AltName: Full=Polyketide synthase-associated protein A5 {ECO:0000256|ARBA:ARBA00032317};
GN ORFNames=NSP_13600 {ECO:0000313|EMBL:AHJ27700.1};
OS Nodularia spumigena CCY9414.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Aphanizomenonaceae;
OC Nodularia.
OX NCBI_TaxID=313624 {ECO:0000313|EMBL:AHJ27700.1, ECO:0000313|Proteomes:UP000019325};
RN [1] {ECO:0000313|EMBL:AHJ27700.1, ECO:0000313|Proteomes:UP000019325}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCY9414 {ECO:0000313|EMBL:AHJ27700.1};
RX PubMed=23555932;
RA Voss B., Bolhuis H., Fewer D.P., Kopf M., Moke F., Haas F., El-Shehawy R.,
RA Hayes P., Bergman B., Sivonen K., Dittmann E., Scanlan D.J., Hagemann M.,
RA Stal L.J., Hess W.R.;
RT "Insights into the physiology and ecology of the brackish-water-adapted
RT Cyanobacterium Nodularia spumigena CCY9414 based on a genome-transcriptome
RT analysis.";
RL PLoS ONE 8:E60224-E60224(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 a mycocerosyl-[mycocerosic acid synthase] + a
CC phenolphthiocerol = a dimycocerosyl phenolphthiocerol + 2 holo-
CC [mycocerosic acid synthase].; EC=2.3.1.282;
CC Evidence={ECO:0000256|ARBA:ARBA00000625};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 a mycocerosyl-[mycocerosic acid synthase] + a phthiocerol =
CC a dimycocerosyl phthiocerol + 2 holo-[mycocerosic acid synthase].;
CC EC=2.3.1.282; Evidence={ECO:0000256|ARBA:ARBA00000026};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 a mycocerosyl-[mycocerosic acid synthase] + a phthiodiolone
CC = a dimycocerosyl phthiodiolone + 2 holo-[mycocerosic acid
CC synthase].; EC=2.3.1.282; Evidence={ECO:0000256|ARBA:ARBA00001907};
CC -!- SIMILARITY: Belongs to the acyltransferase PapA5 family.
CC {ECO:0000256|ARBA:ARBA00006558}.
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DR EMBL; CP007203; AHJ27700.1; -; Genomic_DNA.
DR RefSeq; WP_006195105.1; NZ_CP007203.1.
DR AlphaFoldDB; A0ZCD4; -.
DR STRING; 313624.NSP_13600; -.
DR PATRIC; fig|313624.11.peg.1365; -.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_048554_0_0_3; -.
DR Proteomes; UP000019325; Chromosome.
DR GO; GO:0004314; F:[acyl-carrier-protein] S-malonyltransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR031641; PapA_C.
DR PANTHER; PTHR28037; ALCOHOL O-ACETYLTRANSFERASE 1-RELATED; 1.
DR PANTHER; PTHR28037:SF1; ALCOHOL O-ACETYLTRANSFERASE 1-RELATED; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF16911; PapA_C; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:AHJ27700.1};
KW Transferase {ECO:0000313|EMBL:AHJ27700.1}.
FT DOMAIN 33..175
FT /note="Condensation"
FT /evidence="ECO:0000259|Pfam:PF00668"
FT DOMAIN 240..398
FT /note="Phthiocerol/phthiodiolone dimycocerosyl transferase
FT C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16911"
SQ SEQUENCE 462 AA; 52511 MW; C0ED4D995FDD1FC6 CRC64;
MKTSNILPSL TQQSVQESVE NARNLGCLEQ AMENLNSRAK TWNIVTISRI KGPLSAEILR
QALDIIQRRH PRLNSRIISS TNRLCFQTEG TTKIPVRVVE KFAHEQWQQV VEAEMNQAID
SSKCLMRAVL VHIQSHSHEN YLITTGHHAV GDGLSSIRLH SEILTYCQQI FSGNLINPVT
TLLPLPPVEE LLPRWTKKFR GQISSTLFLL QMGLQKIWHR PQTLGFEKYV PIAQRRCNII
HRQLDPELTQ QLVNTCRQEN TTVNSAFSAA IMLIIARNIT KNKRKAIKLN CLTYLDLRRH
IQPEISDDHM AVLASSIMGF YTIKSNTSFW ELAREVKQKF EASTKRGDIF KMILVAKHLI
DFSLTYPKQV AATVSVSNAG RVNIPKVYGE FELEEISFLG SHALYAGMFI THVSTFQGKM
LLNFVFSEPS ISRNTMEGIV NQLISYISHI CNFKVQPSST QI
//
