ID A0ZWW7_DROSI Unreviewed; 1387 AA.
AC A0ZWW7;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Thiolester containing protein II isoform D {ECO:0000313|EMBL:CAJ18863.1};
DE Flags: Fragment;
GN Name=TepII {ECO:0000313|EMBL:CAJ18863.1};
OS Drosophila simulans (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7240 {ECO:0000313|EMBL:CAJ18863.1};
RN [1] {ECO:0000313|EMBL:CAJ18863.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Kenya line KY228 {ECO:0000313|EMBL:CAJ18863.1};
RA Kim K.W.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAJ18863.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Kenya line KY228 {ECO:0000313|EMBL:CAJ18863.1};
RX PubMed=17103056; DOI=10.1007/s00239-006-0005-2;
RA Jiggins F.M., Kim K.W.;
RT "Contrasting evolutionary patterns in Drosophila immune receptors.";
RL J. Mol. Evol. 63:769-780(2006).
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DR EMBL; AM050191; CAJ18863.1; -; Genomic_DNA.
DR ChiTaRS; Tep2; fly.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02897; A2M_2; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 2.60.40.2950; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR041813; A2M_TED.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF176; GH01829P-RELATED; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT DOMAIN 422..556
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 657..749
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 1275..1365
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
FT COILED 749..776
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CAJ18863.1"
SQ SEQUENCE 1387 AA; 154488 MW; 9E7F45779E077F30 CRC64;
LYSVVGPGTL RSNSKYNVVV SVHKADAPSQ IKVSLNGPSY NETKQIELPP MSTQNVEFEV
PKLATGNYNL TAEGLSGVVF KNSTKLNYAD EKPSVFVQTD KATYKPADLV QFRILFLDEN
TRPAKIEKPI SVIITDGGQN RIKQLSDVKL TKGVFSGELQ LSEQPVLGTW KISVSVDGDN
RETKSFEVDK YVLPKFEVIV DTPKAAVIED KVIKATIRAK YTYGKPVKGK ATVSMERSYG
YFGNLGENDY KQEKTIDVDG KGHVEFDIIS WTQRGQYLPP LKIFAVVTEE LTGNKQNATA
TVVLHQQRYM IEAYERPDHF EANKSFIYQV VVKNVDGSPV TSSAKNVKIG FTNTFSYFNE
MPPVSRINYE APVNENGIAT FNVTLPDSES RYYRIFASFD RSINQLGSIS KFEPTMISRE
PLKIQVNTKK PRLGERVSFD VVSIEDLPYF VYTIVARGNV ILSDYVDVPD GKKTFTVKFT
PTFSMVPKAT IYVHYVVNND LQFEEKTIDF EKEFSNSIDI SAPTNAKPSE EVKLRIKTDA
DSFVGLLGVD QSVLLLKSGN DLSQDDIFNS LNKYQTSTPW MNGYGRYPGQ TSGLVTLTNA
NYPYNTEFPD YVEDDPGIYA FENNLEALPP MPAIANFPPD TGNTIQPVEI RKNFADVWIW
QSIGRXXXXX XLTLTKKIPD TITSWVVTGF SLNPTSGIAL TKSPSKIRVF QPFFVSTNLP
YSVKRGEVIA IPVVIFNYLD KTLDADVVMD NSDQEYEFTE ATNEVLEKAI DEVRRVKRVT
IPANSGKSVS FMIRPKSVGF TTLKITATSA LAGDTIHQKL KVEPEGVTQF ENRAVFINLK
DQPEMSQSLD AEIPSEVVPQ SEFIEFSVVG DLLGPTLQNL DNLVRMPYGC GEQNMVNFVP
NILVLKYLEV TGRKLPSVES KARKFLEIGY QRELTYKHDD GSYSAFGKSD ASGSTWLTAY
VMRSFHQAGT YTDIDPKVIT AGLDFLVSKQ KESGEFPEVG KLFDNANQNP LALTSFVLLA
FFENHELIPK YQSAIEKAVR YVAEEADKTD DQYSLAIAAV ALQLAKHPQA EKVLAKLESM
ARNENDRMWW SKTTESTGED GRVFHWKPRS NDVEITSYVL LALLEKDPAE KALPIIKWLI
SQRNSNGGFS STQDTVIGLQ ALTKFAYKTG SGSGTMDIEF SSAGESNNTI KLNPENSLVL
QTHVLPKSTR KVDFTAKGTG SAMVQLSYRY NLAQKEKKPS FKVTPTVKDT PNQLLVVDIC
AEYVPLEDAD KEKDSNMAVM EIALPSGFVG DDESLSKIQA VDRVKRVETK NSDSTVVVYF
DSLTPGDVHC LPLEASKAHA VAKQKPASVS LYDYYDTDRK ATEYYQVKSS LCDICEGADC
GEGCKKD
//
