ID A0ZWW9_DROSI Unreviewed; 1378 AA.
AC A0ZWW9;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Thiolester containing protein II isoform B {ECO:0000313|EMBL:CAJ18865.1};
DE Flags: Fragment;
GN Name=TepII {ECO:0000313|EMBL:CAJ18865.1};
OS Drosophila simulans (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7240 {ECO:0000313|EMBL:CAJ18865.1};
RN [1] {ECO:0000313|EMBL:CAJ18865.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Kenya line KY236 {ECO:0000313|EMBL:CAJ18865.1};
RA Kim K.W.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAJ18865.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Kenya line KY236 {ECO:0000313|EMBL:CAJ18865.1};
RX PubMed=17103056; DOI=10.1007/s00239-006-0005-2;
RA Jiggins F.M., Kim K.W.;
RT "Contrasting evolutionary patterns in Drosophila immune receptors.";
RL J. Mol. Evol. 63:769-780(2006).
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DR EMBL; AM050192; CAJ18865.1; -; Genomic_DNA.
DR ChiTaRS; Tep2; fly.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02897; A2M_2; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 2.60.40.2950; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR041813; A2M_TED.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF176; GH01829P-RELATED; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT DOMAIN 422..556
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 649..740
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 1266..1356
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
FT COILED 740..767
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CAJ18865.1"
SQ SEQUENCE 1378 AA; 153768 MW; A641BF28C5A6130A CRC64;
LYSVVGPGTL RSNSKYNVVV SVHKADAPSQ IKVSLNGPSY NETKQIELPP MSTQNVEFEV
PKLATGNYNL TAEGLSGVVF KNSTKLNYAD EKPSVFVQTD KATYKPADLV QFRILFLDEN
TRPAKIEKPI SVIITDGAQN RIKQLNDVKL TKGVFSGELQ LSEQPVLGTW KISVSVDGDN
RETKSFEVDK YVLPKFEVIV DTPKAAVIED KVIKATIRAK YTYGKPVKGK ATVSMERSYG
YFGNLGENDY KQEKTIDVDG KGHVEFDIIS WTQRGQYLPP VKLFAVVTEE LTGNKQNATA
TVVLHQQRYM IEAYERPDHF EANKSFIYQV VVKNVDGSPV TSSAKNVKIG FTNTFSYFIE
MPPVSRINYE APVNENGIAT FNVTLPDSES RYYRIFASFD RSINQLGSIS KFEPTMISRE
PLKIQVNTKK PRLGERVSFD VVSIEDLPYF VYTIVARGNV ILSDYVDVPD GKKTFTVKFT
PTFSMVPKAT IYVHYVVNND LQFEEKTIDF EKEFSNSIDI SAPTNAKPSE EVKLRIKTDA
DSFVGLLGVD QSVLLLKSGN DLSQDDIFNS LNKYQTSTPW MNGYGRYPGQ TSGLVTLTNA
NYPYNTERRI FIRPGIGFPR PLFNRVTVTG SLAQNVLTEP QVRKEFPENW IFNIFEXXXX
XXLTLTKKIP DTITSWVVTG FSLNPTSGIA LTKSPSKIRV FQPFFVSTNL PYSVKRGEVI
AIPVVIFNYL DKTLDADVVM DNSDQEYEFT EATNEVLEKA IDEVRRVKRV TIPANSGKSV
SFMIRPKSVG FTTLKITATS ALAGDTIHQK LKVEPEGVTQ FENRAVFINL KDQPEMSQSL
DAEIPSEVVP QSEFIEFSXX XXLLGPTLQN LDNLVRMPYG CGEQNMVNFV PNILVLKYLE
VTGRKLPSVE SKARKFLEIG YQRELTYKHD DGSYSAFGKS DASGSTWLTA YVMRSFHQAG
TYTDIDPKVI TAGLDFLVSK QKESGEFPEV GKLFDNANQN PLALTSFVLL AFFENHELIP
KYQGAIEKAV RYVAEEADKT DDQYSLAIAA VALQLAKHPQ AEKVLAKLES MARNENDRMW
WSKTTESTGE DGRVFHWKPR SNDVEITSYV LLALLEKDPA EKALPIIKWL ISQRNSNGGF
SSTQDTVIGL QALTKFAYKT GSGSGTMDIE FSAAGESNNT IKVNPENSLV LQTHVLPKST
RKVDFTAKGT GSAMVQLSYR YNLAQKEKKP SFKVTPTVKD TPNQLLVVDI CAEYVPLEDA
DKEKDSNMAV MEIALPSGFV GDDESLSKIQ AVDRVKRVET KNSDSTVVVY FDSLTPGDVH
CLPLEASKAH AVAKQKPASV SLYDYYDTER KATEYYQVKS SLCEICEGAD CGEGCKKD
//
