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Database: UniProt
Entry: A1A2H5
LinkDB: A1A2H5
Original site: A1A2H5 
ID   HIS7_BIFAA              Reviewed;         199 AA.
AC   A1A2H5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-SEP-2014, entry version 49.
DE   RecName: Full=Imidazoleglycerol-phosphate dehydratase;
DE            Short=IGPD;
DE            EC=4.2.1.19;
GN   Name=hisB; OrderedLocusNames=BAD_1127;
OS   Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC
OS   11814 / E194a).
OC   Bacteria; Actinobacteria; Actinobacteridae; Bifidobacteriales;
OC   Bifidobacteriaceae; Bifidobacterium.
OX   NCBI_TaxID=367928;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15703 / DSM 20083 / NCTC 11814 / E194a;
RA   Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S.,
RA   Hirai S., Tanaka K., Watanabe K.;
RT   "Bifidobacterium adolescentis complete genome sequence.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: D-erythro-1-(imidazol-4-yl)glycerol 3-
CC       phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-
CC       histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the imidazoleglycerol-phosphate dehydratase
CC       family.
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DR   EMBL; AP009256; BAF39908.1; -; Genomic_DNA.
DR   RefSeq; WP_011743463.1; NC_008618.1.
DR   RefSeq; YP_909990.1; NC_008618.1.
DR   ProteinModelPortal; A1A2H5; -.
DR   STRING; 367928.BAD_1127; -.
DR   EnsemblBacteria; BAF39908; BAF39908; BAD_1127.
DR   GeneID; 4556151; -.
DR   KEGG; bad:BAD_1127; -.
DR   PATRIC; 21101687; VBIBifAdo27973_1207.
DR   eggNOG; COG0131; -.
DR   HOGENOM; HOG000228064; -.
DR   KO; K01693; -.
DR   OMA; EDTAIVM; -.
DR   OrthoDB; EOG60PHGP; -.
DR   BioCyc; BADO367928:GHPT-1174-MONOMER; -.
DR   UniPathway; UPA00031; UER00011.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004424; F:imidazoleglycerol-phosphate dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_00076; HisB; 1.
DR   InterPro; IPR000807; ImidazoleglycerolP_deHydtase.
DR   InterPro; IPR020565; ImidazoleglycerP_deHydtase_CS.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   PANTHER; PTHR23133:SF2; PTHR23133:SF2; 1.
DR   Pfam; PF00475; IGPD; 1.
DR   SUPFAM; SSF54211; SSF54211; 2.
DR   PROSITE; PS00954; IGP_DEHYDRATASE_1; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm;
KW   Histidine biosynthesis; Lyase.
FT   CHAIN         1    199       Imidazoleglycerol-phosphate dehydratase.
FT                                /FTId=PRO_1000010245.
SQ   SEQUENCE   199 AA;  21542 MW;  9224CCAD5C8C450A CRC64;
     MARTATIVRE TSESKVELSL NLDGTGKTDI DTSVPFYNHM MTALGKHSLI DLKIKATGDT
     DIDAHHTVED IAIVFGEALK QALGDKRGIR RFADATVPLD EALAKAVVDI SGRPYCVCTG
     EPEGFEYCMI GGHFTGSLVR HVMESIAMHA GICLHLHVIS GRDPHHIAEV EFKALARALR
     FAIEPDPRVD GIPSTKGAL
//
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