ID HIS7_BIFAA Reviewed; 199 AA.
AC A1A2H5;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 01-MAY-2013, entry version 43.
DE RecName: Full=Imidazoleglycerol-phosphate dehydratase;
DE Short=IGPD;
DE EC=4.2.1.19;
GN Name=hisB; OrderedLocusNames=BAD_1127;
OS Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC
OS 11814 / E194a).
OC Bacteria; Actinobacteria; Actinobacteridae; Bifidobacteriales;
OC Bifidobacteriaceae; Bifidobacterium.
OX NCBI_TaxID=367928;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15703 / DSM 20083 / NCTC 11814 / E194a;
RA Suzuki T., Tsuda Y., Kanou N., Inoue T., Kumazaki K., Nagano S.,
RA Hirai S., Tanaka K., Watanabe K.;
RT "Bifidobacterium adolescentis complete genome sequence.";
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY: D-erythro-1-(imidazol-4-yl)glycerol 3-
CC phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O.
CC -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-
CC histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the imidazoleglycerol-phosphate dehydratase
CC family.
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DR EMBL; AP009256; BAF39908.1; -; Genomic_DNA.
DR RefSeq; YP_909990.1; NC_008618.1.
DR ProteinModelPortal; A1A2H5; -.
DR STRING; 367928.BAD_1127; -.
DR EnsemblBacteria; BAF39908; BAF39908; BAD_1127.
DR GeneID; 4556151; -.
DR KEGG; bad:BAD_1127; -.
DR PATRIC; 21101687; VBIBifAdo27973_1207.
DR eggNOG; COG0131; -.
DR HOGENOM; HOG000228064; -.
DR KO; K01693; -.
DR OMA; HHIVEAC; -.
DR ProtClustDB; PRK00951; -.
DR BioCyc; BADO367928:GHPT-1183-MONOMER; -.
DR UniPathway; UPA00031; UER00011.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004424; F:imidazoleglycerol-phosphate dehydratase activity; IEA:HAMAP.
DR GO; GO:0000105; P:histidine biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_00076; HisB; 1; -.
DR InterPro; IPR000807; ImidazoleglycerolP_deHydtase.
DR InterPro; IPR020565; ImidazoleglycerP_deHydtase_CS.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR PANTHER; PTHR23133:SF2; PTHR23133:SF2; 1.
DR Pfam; PF00475; IGPD; 1.
DR SUPFAM; SSF54211; Ribosomal_S5_D2-typ_fold; 2.
DR PROSITE; PS00954; IGP_DEHYDRATASE_1; 1.
DR PROSITE; PS00955; IGP_DEHYDRATASE_2; FALSE_NEG.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Complete proteome; Cytoplasm;
KW Histidine biosynthesis; Lyase.
FT CHAIN 1 199 Imidazoleglycerol-phosphate dehydratase.
FT /FTId=PRO_1000010245.
SQ SEQUENCE 199 AA; 21542 MW; 9224CCAD5C8C450A CRC64;
MARTATIVRE TSESKVELSL NLDGTGKTDI DTSVPFYNHM MTALGKHSLI DLKIKATGDT
DIDAHHTVED IAIVFGEALK QALGDKRGIR RFADATVPLD EALAKAVVDI SGRPYCVCTG
EPEGFEYCMI GGHFTGSLVR HVMESIAMHA GICLHLHVIS GRDPHHIAEV EFKALARALR
FAIEPDPRVD GIPSTKGAL
//
