ID A1A5W7_DANRE Unreviewed; 433 AA.
AC A1A5W7; A0A8M1NCK4;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=Zgc:158316 {ECO:0000313|EMBL:AAI28841.1, ECO:0000313|Ensembl:ENSDARP00000141621};
GN Name=hycc2 {ECO:0000313|ZFIN:ZDB-GENE-061215-98};
GN ORFNames=zgc:158316 {ECO:0000313|EMBL:AAI28841.1,
GN ECO:0000313|RefSeq:NP_001073543.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI28841.1};
RN [1] {ECO:0000313|EMBL:AAI28841.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAI28841.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000141621, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000141621};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|Ensembl:ENSDARP00000141621}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000141621};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:NP_001073543.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [5] {ECO:0000313|RefSeq:NP_001073543.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the Hyccin family.
CC {ECO:0000256|ARBA:ARBA00034482}.
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DR EMBL; CU694490; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; FQ377630; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC128840; AAI28841.1; -; mRNA.
DR RefSeq; NP_001073543.1; NM_001080074.1.
DR STRING; 7955.ENSDARP00000141621; -.
DR PaxDb; 7955-ENSDARP00000115123; -.
DR Ensembl; ENSDART00000163529.2; ENSDARP00000141621.1; ENSDARG00000101696.2.
DR GeneID; 790929; -.
DR KEGG; dre:790929; -.
DR AGR; ZFIN:ZDB-GENE-061215-98; -.
DR CTD; 285172; -.
DR ZFIN; ZDB-GENE-061215-98; hycc2.
DR eggNOG; KOG4688; Eukaryota.
DR HOGENOM; CLU_027457_3_0_1; -.
DR OMA; HEKCWKE; -.
DR OrthoDB; 3089164at2759; -.
DR Proteomes; UP000000437; Chromosome 9.
DR Bgee; ENSDARG00000101696; Expressed in intestine and 22 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IBA:GO_Central.
DR GO; GO:0072659; P:protein localization to plasma membrane; IBA:GO_Central.
DR InterPro; IPR018619; Hyccin.
DR PANTHER; PTHR31220; HYCCIN RELATED; 1.
DR PANTHER; PTHR31220:SF3; PROTEIN FAM126B; 1.
DR Pfam; PF09790; Hyccin; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT REGION 337..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..393
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..409
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..433
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 433 AA; 47998 MW; 59313D0FABCB6CF6 CRC64;
MATESAIVQD WLSEYKALSE AQRCGYASVL QQRETLVPAL YSVIQNPHSE LLEPVCHQLF
ELYRSSEERL RCFTLQFLPE LLWVFLRRGA ADASGSVQAL LLGIYNLEIV DKDGNSKLLS
FMIPSLSKPS IYHEPSSLGS MALTEGALCQ HDLIRVVYSG LHPQRETFTA QNRFEVLCFL
MLCYNSVVVY MPSSSYRAVC RMSSRLCVCG FPRQQLKAWS APGLRVMLDP EFMVQMLTAV
YHAIFNGEWD AGREALDDIL YRAELELYSE PLLLGNAMRS SLPVSAPGGS AGSRRLLQVE
VTPTASRITH CSITAASIRR LRWQREDADQ LSGDEECLAL NDPDEGFSSG ASSSSRGNAA
SRLCASKKSR VRSRQGAGLP RSSSSSSART APVEPRSPDT RRLSNRSLPE EPEPMRGPQS
RSPSCNMQII SQV
//
