ID A1ATM5_PELPD Unreviewed; 2336 AA.
AC A1ATM5;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 104.
DE SubName: Full=Beta-hydroxyacyl-(Acyl-carrier-protein) dehydratase, FabA/FabZ {ECO:0000313|EMBL:ABL00696.1};
GN OrderedLocusNames=Ppro_3102 {ECO:0000313|EMBL:ABL00696.1};
OS Pelobacter propionicus (strain DSM 2379 / NBRC 103807 / OttBd1).
OC Bacteria; Thermodesulfobacteriota; Desulfuromonadia; Desulfuromonadales;
OC Desulfuromonadaceae; Pelobacter.
OX NCBI_TaxID=338966 {ECO:0000313|EMBL:ABL00696.1, ECO:0000313|Proteomes:UP000006732};
RN [1] {ECO:0000313|EMBL:ABL00696.1, ECO:0000313|Proteomes:UP000006732}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 2379 / NBRC 103807 / OttBd1
RC {ECO:0000313|Proteomes:UP000006732};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Saunders E., Brettin T., Bruce D., Han C., Tapia R., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Lovley D.,
RA Richardson P.;
RT "Complete sequence of chromosome of Pelobacter propionicus DSM 2379.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005194}.
CC -!- SIMILARITY: Belongs to the thioester dehydratase family. FabA
CC subfamily. {ECO:0000256|ARBA:ARBA00006714}.
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DR EMBL; CP000482; ABL00696.1; -; Genomic_DNA.
DR RefSeq; WP_011736928.1; NC_008609.1.
DR STRING; 338966.Ppro_3102; -.
DR KEGG; ppd:Ppro_3102; -.
DR eggNOG; COG0764; Bacteria.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_000022_30_0_7; -.
DR OrthoDB; 5476655at2; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000006732; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0008693; F:(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity; IEA:InterPro.
DR GO; GO:0008659; F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0034017; F:trans-2-decenoyl-acyl-carrier-protein isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd01287; FabA; 2.
DR CDD; cd00833; PKS; 2.
DR Gene3D; 3.40.47.10; -; 2.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 4.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR010083; FabA.
DR InterPro; IPR013114; FabA_FabZ.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43074; OMEGA-3 POLYUNSATURATED FATTY ACID SYNTHASE PFAB-RELATED; 1.
DR PANTHER; PTHR43074:SF1; PKS_AT DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF07977; FabA; 3.
DR Pfam; PF00109; ketoacyl-synt; 2.
DR Pfam; PF02801; Ketoacyl-synt_C; 2.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 4.
DR SUPFAM; SSF53901; Thiolase-like; 3.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 2.
PE 3: Inferred from homology;
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023160};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000006732}.
FT DOMAIN 4..446
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 466..925
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 1415..1474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2336 AA; 253487 MW; 72A2FF91E29DDDC6 CRC64;
MHQSSSVAIV GIGGIFPDAP DLARFWDNIR LARSASRVVP EGRWRLGVET AYHPEVGRVD
HVYSRHGCFI QEIPSLAGLS GLAPGFQLPD GLDPLFHLLI HAGTRAFDDG ITEPLDRSRI
GVIIGNLALP SETSALISRQ WLGRSFQEKL LGHAPQASAV NPINRYVAGL PAGMLAQALG
LGGTSCALDA ACASSLYAIK LACDELLSGR TDAMLSGGLS RPDPLYTQMG FSQLRALSRR
GICSPFDASG DGLVVGEGAG IFLLKRTEDA LAHGDRIYGI IRGIGLSNDV GGSLLAPLSE
GQVRAMRNAY ARAGWDPSDV DLIECHATGT QVGDATEVAS LRELWGASRP EGRTCVIGSI
KSNIGHLLTA AGAAALTKVL LAMTEEQLPP TANFSSPQPG MDLDNSPFRV LTEGIPWERR
GKGIPRRAAV SAFGFGGINA HLLVEEWLPE SGRTRPGKHD QKPKPHPGVA VVGMDARFGP
WQSLRAFQER VLGGGPHTTP TPPTRWWGAQ ESAWYQEEGL QQTPFNGFYL DEVAVAAEQF
RIPPREIEEM LPQQILMLTS AAAAMADAGL DREGNLRAGV FVGISLDLNS TNFSFRWSLA
ERAKEWAREL GRQMSAEELA SWINQLRDDA SPPLTANRTM GALGNIVASR IAREFRVGGP
SFALAGEENS GIRSLETAAR MLQSGEIDRA LVGAVDLAGD LRAVLGRHDQ RPFSTSGRAL
PFDQRADGSL AGEGAASVVL KRLDDAERDG DRIYAVIRGI GSSSGETTTS SREEGYCRAL
ERAYSDAGVN PVTVSYLEAH ASGLPAEDRM EAAALASFFG TSPTDDTPPR RERSCAVSSV
AADIGQSGAA SGLASLVRGC LALYQEIIPP CRGVETPCHE LSSPGPLYIP RAPRYWLRNR
GEGPRRAGVS VFSTDGGCSH VVLEGWDNQP QRFEAERMAP LGPGSEFLFT LCGDNPADLT
RGLGLLRQRA AHAADDGLGT LAREWYDRAV THDSEAKARP RALALVARTR DELMALIDRG
EELLASGCST AELLAHPALH DRLFYSPAPL GLEGKLAFVF PGSGNHYPGM GMELSCHWPG
ILRSQDENNL YLRSQFQPER FWNGAPSAEI DNDHRAVLFG QVAIGCIASD LVRGFGVEPQ
AAIGYSLGES AALFALGAWH DRDGMLTRMH NSTLFTRDLA GECRAAQRAW GLAEGTEVQW
SIGMVAASAT EVTRALEGTA RVYLLIVNTP DECVIGGDSD EVSQVVERIK RPFFPLRGVT
TAHCGVAREV AGPYRQLHLF PTTPPAGIRF YSGARNAAYE LNRESAADSI LAQAVEGINF
PATIQQAYDD GVRLFLEMGP GSSCSRMIGR ILEERPHLAR PICHQGQDQL SGLLRLLAQL
TAERVPLDLS PLFPAPAVTL AEKAKGTMVR VPCGGLPFQP SLPPRRSRPA LKQDPPPSEA
SVPREGGGAQ PASLPFSREE RRAHSSPHDL GTSLHGQVIN DFAASQQAQI RAHEAYLKVS
ENLTGGMLQA LRLQAALTQA LGDDLPPVLP PLAGEEAGAV TAASTPPRPA PPRTCVFDRD
MCLEFATGSV GRMLGPDFAE LDRLPTRVRL PDEPLMLVDR IVVLEGEPRS MTSGRVVTEH
DILANAWYLD GGRIPTCIAV EAGQADLFLS GYLGIDFITR GLAVYRLLDA VVTFHRPLPV
AGETIRYDIR IERFFRQGDT YLFRFRFDAT VGGKPLLTMR DGSAGFFTSQ ELEAGRGIVR
PAVDPRPTKG LLPDNWRDLV PLEREGYDGD QLDRLRRGDL AGCFGPSFSR LGLNHPLTIP
GGAMRLVHRV REIDPSGGRY GLGQIIAEAD IHPDDWFITC HFVDDRVMPG TLMYECCMHT
LRILLLRRGW VAETGRATWE PLPGVDSRLR CRGQVLESTK VVTYEVAIRQ LGYGPEPFAI
ADALMYADGK PIVEIGDMSV RLSGTGREEL EALWRGGHGA VETHCNASLQ KPAIYTKQQI
LAYSNGNPSE GFGEPYRVFD SQRRIARLPG PPFQFMDRIT AVQGEPWRMV AGPWAEAQYD
IPGDAWYFAA ERQGRMPFAV LLEAALQPCG WLAAYVGSAL TSPSDISFRN LGGNAVRHRD
VTPDSGTLTM TASLTKVATS GGMIIQEYDF AVADQEGMVY EGETMFGFFS REALASQVGI
RDATPYLPTA EEIARGRALS YPTEPPYPEK QLRMIDRIEL FVADGGPAGL GYLRGVKEVD
PEEWFFTAHF YQDPVTPGSL GLESFLQLVK FAAVERWGWG QDSVLSPAAT GQRHRWLYRG
QVVPTNSTVT VEAWITSCDD DQRLLVADGM LSVDGRPIYQ MNDFTLRMER PFLEKQ
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