ID   A1B864_PARDP            Unreviewed;       289 AA.
AC   A1B864;
DT   23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT   23-JAN-2007, sequence version 1.
DT   27-MAR-2024, entry version 80.
DE   SubName: Full=Hydroxymethylglutaryl-CoA lyase {ECO:0000313|EMBL:ABL71708.1};
DE            EC=4.1.3.4 {ECO:0000313|EMBL:ABL71708.1};
GN   OrderedLocusNames=Pden_3641 {ECO:0000313|EMBL:ABL71708.1};
OS   Paracoccus denitrificans (strain Pd 1222).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Paracoccaceae; Paracoccus.
OX   NCBI_TaxID=318586 {ECO:0000313|EMBL:ABL71708.1, ECO:0000313|Proteomes:UP000000361};
RN   [1] {ECO:0000313|Proteomes:UP000000361}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pd 1222 {ECO:0000313|Proteomes:UP000000361};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Spiro S.,
RA   Richardson D.J., Moir J.W.B., Ferguson S.J., van Spanning R.J.M.,
RA   Richardson P.;
RT   "Complete sequence of chromosome 2 of Paracoccus denitrificans PD1222.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the HMG-CoA lyase family.
CC       {ECO:0000256|ARBA:ARBA00009405}.
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DR   EMBL; CP000490; ABL71708.1; -; Genomic_DNA.
DR   RefSeq; WP_011749877.1; NC_008687.1.
DR   AlphaFoldDB; A1B864; -.
DR   STRING; 318586.Pden_3641; -.
DR   EnsemblBacteria; ABL71708; ABL71708; Pden_3641.
DR   GeneID; 75503034; -.
DR   KEGG; pde:Pden_3641; -.
DR   eggNOG; COG0119; Bacteria.
DR   HOGENOM; CLU_022138_3_2_5; -.
DR   OrthoDB; 9784013at2; -.
DR   Proteomes; UP000000361; Chromosome 2.
DR   GO; GO:0004419; F:hydroxymethylglutaryl-CoA lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd07938; DRE_TIM_HMGL; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR043594; HMGL.
DR   InterPro; IPR000891; PYR_CT.
DR   PANTHER; PTHR42738; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR   PANTHER; PTHR42738:SF7; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR   Pfam; PF00682; HMGL-like; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
DR   PROSITE; PS50991; PYR_CT; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000313|EMBL:ABL71708.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000361}.
FT   DOMAIN          4..271
FT                   /note="Pyruvate carboxyltransferase"
FT                   /evidence="ECO:0000259|PROSITE:PS50991"
SQ   SEQUENCE   289 AA;  30214 MW;  A67AA6BB051D6C17 CRC64;
     MSRVEIFEVG PRDGLQNEKR LIPAAEKVAL VDLLSQAGFR RIEVTSFVPP KWVPQMADAA
     EVMAGITRHA GIRYAVLTPN LRGYEAAKAA GADEVAIFAS ASEGFSRANL NATIAESLER
     FAPVAEAARA DGIPLRGYVS VVTDCPFDGP VPPANVARVT AALRDMGCYE VSLGDTIGQG
     RPETIDAMLS AVLEELPPEN LAGHYHDTAG RALENVDASL SRGLRVFDAA VGGLGGCPYA
     PGAAGNVATE KLAAHLAAHG HDTGLDMAVI EQAAAMARTM RARTMRGGA
//