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Database: UniProt
Entry: A1BQQ5
LinkDB: A1BQQ5
Original site: A1BQQ5 
ID   MR30_CONMR              Reviewed;         289 AA.
AC   A1BQQ5; A1BQQ6; A1BQQ7; A4ZXA1;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   19-FEB-2014, entry version 37.
DE   RecName: Full=Cysteine-rich venom protein Mr30;
DE            Short=CRVP;
DE   AltName: Full=Cysteine-rich secretory protein Mr30;
DE   AltName: Full=GlaCrisp isoform 1/2/3;
DE   AltName: Full=Mr30-1/2;
DE   Flags: Precursor;
OS   Conus marmoreus (Marble cone).
OC   Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Hypsogastropoda; Neogastropoda; Conoidea; Conidae;
OC   Conus.
OX   NCBI_TaxID=42752;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 25-39; 64-69; 81-93;
RP   179-186; 239-248 AND 279-284, GAMMA-CARBOXYGLUTAMATION AT GLU-33, AND
RP   FUNCTION (VARIANTS ISOFORM 1/2/3).
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=17042501; DOI=10.1021/bi061311a;
RA   Hansson K., Thamlitz A.-M., Furie B., Furie B.C., Stenflo J.;
RT   "A single gamma-carboxyglutamic acid residue in a novel cysteine-rich
RT   secretory protein without propeptide.";
RL   Biochemistry 45:12828-12839(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 25-39, FUNCTION, AND
RP   MASS SPECTROMETRY (VARIANTS MR30-1 AND MR30-2).
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=18235980; DOI=10.1111/j.1745-7270.2008.00385.x;
RA   Qian J., Guo Z.Y., Chi C.W.;
RT   "Cloning and isolation of a conus cysteine-rich protein homologous to
RT   Tex31 but without proteolytic activity.";
RL   Acta Biochim. Biophys. Sin. 40:174-181(2008).
CC   -!- FUNCTION: Has no proteolytic activity.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- PTM: Contains 11 disulfide bonds.
CC   -!- MASS SPECTROMETRY: Mass=29665; Method=Unknown; Range=25-289;
CC       Note=in variant Mr30-2; Source=PubMed:18235980;
CC   -!- MASS SPECTROMETRY: Mass=29666; Method=Unknown; Range=25-289;
CC       Note=in variant Mr30-1; Source=PubMed:18235980;
CC   -!- SIMILARITY: Belongs to the CRISP family.
CC   -!- SIMILARITY: Contains 1 SCP domain.
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DR   EMBL; EF493183; ABP48101.1; -; mRNA.
DR   EMBL; EF493184; ABP48102.1; -; mRNA.
DR   EMBL; DQ647193; ABG36843.1; -; mRNA.
DR   EMBL; DQ647194; ABG36844.1; -; mRNA.
DR   EMBL; DQ647195; ABG36845.1; -; mRNA.
DR   ProteinModelPortal; A1BQQ5; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR001283; Allrgn_V5/Tpx1.
DR   InterPro; IPR014044; CAP_domain.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PRINTS; PR00837; V5TPXLIKE.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Gamma-carboxyglutamic acid; Secreted; Signal.
FT   SIGNAL        1     24
FT   CHAIN        25    289       Cysteine-rich venom protein Mr30.
FT                                /FTId=PRO_0000326274.
FT   DOMAIN       62    184       SCP.
FT   COMPBIAS    200    288       Cys-rich.
FT   MOD_RES      33     33       4-carboxyglutamate.
FT   VARIANT      19     19       V -> A (in isoform 1, isoform 2 and Mr30-
FT                                1).
FT   VARIANT      33     33       E -> D (in isoform 1, isoform 2 and Mr30-
FT                                1).
FT   VARIANT      49     49       V -> M (in isoform 1).
FT   VARIANT     186    186       K -> E (in Mr30-1).
SQ   SEQUENCE   289 AA;  32251 MW;  FE3FE5B96C9D8F11 CRC64;
     MLSTMQTVGA ILMLSIVFVA GTKRHACDSK YSEVTPTHTM CLTDNANAVA VTLTQEVKVQ
     IVRMHNVIRA TVNDAANMMK MEWDDRLAAV AQKWAMQCIL GHDGFANHAE PDLPGYVGQN
     VGWSNYHMTF PDVVDLWAAE IEDYEYGVWN DNTGHYIQQI YAEASRIGCG QSACGEDRYF
     VCNYYKSTMG NTPYAQGSRC GQCPNSCWEE LCDCTSGPDA CCNGGSLNID TCECQCPRLW
     SGADCQEKQC PDHDYEDMCD YPDVVNNPEY WCQFSNIRSD CPIRCGDCP
//
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