ID A1C497_ASPCL Unreviewed; 525 AA.
AC A1C497;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Acetyl-CoA hydrolase {ECO:0000256|ARBA:ARBA00017958};
DE EC=3.1.2.1 {ECO:0000256|ARBA:ARBA00011920};
DE AltName: Full=Acetyl-CoA deacylase {ECO:0000256|ARBA:ARBA00029672};
GN ORFNames=ACLA_058990 {ECO:0000313|EMBL:EAW15237.1};
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612 {ECO:0000313|EMBL:EAW15237.1, ECO:0000313|Proteomes:UP000006701};
RN [1] {ECO:0000313|EMBL:EAW15237.1, ECO:0000313|Proteomes:UP000006701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1
RC {ECO:0000313|Proteomes:UP000006701};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H2O = acetate + CoA + H(+); Xref=Rhea:RHEA:20289,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=3.1.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001831};
CC -!- SIMILARITY: Belongs to the acetyl-CoA hydrolase/transferase family.
CC {ECO:0000256|ARBA:ARBA00009632}.
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DR EMBL; DS026990; EAW15237.1; -; Genomic_DNA.
DR RefSeq; XP_001276663.1; XM_001276662.1.
DR AlphaFoldDB; A1C497; -.
DR STRING; 344612.A1C497; -.
DR EnsemblFungi; EAW15237; EAW15237; ACLA_058990.
DR GeneID; 4709033; -.
DR KEGG; act:ACLA_058990; -.
DR VEuPathDB; FungiDB:ACLA_058990; -.
DR eggNOG; KOG2828; Eukaryota.
DR HOGENOM; CLU_019748_3_0_1; -.
DR OMA; DEALSWH; -.
DR OrthoDB; 100792at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0008775; F:acetate CoA-transferase activity; IEA:InterPro.
DR GO; GO:0003986; F:acetyl-CoA hydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0006083; P:acetate metabolic process; IEA:InterPro.
DR Gene3D; 3.30.750.70; 4-hydroxybutyrate coenzyme like domains; 1.
DR Gene3D; 3.40.1080.20; Acetyl-CoA hydrolase/transferase C-terminal domain; 1.
DR Gene3D; 3.40.1080.10; Glutaconate Coenzyme A-transferase; 1.
DR InterPro; IPR026888; AcetylCoA_hyd_C.
DR InterPro; IPR038460; AcetylCoA_hyd_C_sf.
DR InterPro; IPR046433; ActCoA_hydro.
DR InterPro; IPR003702; ActCoA_hydro_N.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR PANTHER; PTHR43609; ACETYL-COA HYDROLASE; 1.
DR PANTHER; PTHR43609:SF1; ACETYL-COA HYDROLASE; 1.
DR Pfam; PF13336; AcetylCoA_hyd_C; 1.
DR Pfam; PF02550; AcetylCoA_hydro; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:EAW15237.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006701}.
FT DOMAIN 13..230
FT /note="Acetyl-CoA hydrolase/transferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02550"
FT DOMAIN 333..483
FT /note="Acetyl-CoA hydrolase/transferase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13336"
SQ SEQUENCE 525 AA; 58000 MW; 04C47A2E5C96E2A1 CRC64;
MAASALLKSR VRRPSYLQKL AKAEDLIDLF PHGTYIGWSG FTGVGYPKKV PTALADHVEK
NNLQGKLKYS LFVGASSGAD TENRWAALNM IERRSPHQVG KEIAKGINNG QINFFDKHLS
MFPSDLVYGW YTMNKPNNKL DIAVIEASAI TEEGGIIPGA SVGASPELIQ MADKVIIEVN
TASPSFEGLH DITMSDLPPN RKPYLIMQPE DRIGTPHIPI DPEKVVAIVE SDYPDQTLPN
APEDESSQAI ATNLIEFLKH EVKHGRLPPN LLPIQSGIGN IANAVIGGLS KGGADFTHLK
VWTEVLQDSF LDLFDSGNLD FATATSIRFS PDGFKRFYDN WERYAGKLLL RSQQVSNSPE
IIRRLGCIGM NTPVEVDIYA HANSTCVMGS RMLNGLGGSA DFLRNSKYSI MHTPSTRPSK
IDPTGVSCIV PFCTHIDQTE HDLDVVVTEQ GLADVRGLSP RERARVIIKH CAHPDYQPIL
TDYLDRAEYE CLKKGMGHEP HLLFQAFKMH QNLAEKGTMK ISGWE
//
