ID A1C6G9_ASPCL Unreviewed; 384 AA.
AC A1C6G9;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Aryl-alcohol dehydrogenase (AAD), putative {ECO:0000313|EMBL:EAW13990.1};
GN ORFNames=ACLA_070220 {ECO:0000313|EMBL:EAW13990.1};
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612 {ECO:0000313|EMBL:EAW13990.1, ECO:0000313|Proteomes:UP000006701};
RN [1] {ECO:0000313|EMBL:EAW13990.1, ECO:0000313|Proteomes:UP000006701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1
RC {ECO:0000313|Proteomes:UP000006701};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- SIMILARITY: Belongs to the aldo/keto reductase family. Aldo/keto
CC reductase 2 subfamily. {ECO:0000256|ARBA:ARBA00038157}.
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DR EMBL; DS027045; EAW13990.1; -; Genomic_DNA.
DR RefSeq; XP_001275416.1; XM_001275415.1.
DR AlphaFoldDB; A1C6G9; -.
DR STRING; 344612.A1C6G9; -.
DR EnsemblFungi; EAW13990; EAW13990; ACLA_070220.
DR GeneID; 4707507; -.
DR KEGG; act:ACLA_070220; -.
DR VEuPathDB; FungiDB:ACLA_070220; -.
DR eggNOG; KOG1575; Eukaryota.
DR HOGENOM; CLU_023205_2_0_1; -.
DR OMA; HIELYQM; -.
DR OrthoDB; 2309211at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd19147; AKR_AKR9A3_9B1-4; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43364:SF2; ARYL-ALCOHOL DEHYDROGENASE AAD10-RELATED; 1.
DR PANTHER; PTHR43364; NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006701}.
FT DOMAIN 32..340
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
SQ SEQUENCE 384 AA; 42715 MW; 4B181DB8D2F1BFAF CRC64;
MAEIFRPAPE PSTELGRYRI LSSTAGIRVS PLQLGAMSIG DSWSYILGSM DKESSFKLLD
AFVEAGGNFI DTANNYQDEQ SETWIGEWMA ARQNRDRMVI ATKFTTDYRS HAVGKGNAPN
CCGNHRRNLN ISVRDSLQKL QTDYIDILYL HWWDYTTSIE EVMDSMHMLV EQGKVMYLGI
SDAPAWVVSA ANTYARAHGK TPFSIYQGRW NVMLRDFERD IIPMARHFGM ALAPWDVLGS
GKFQTKKALE ERKKKGEQLR SLDPVKEQTE EEARMSEALA KVAAEHGIES VTAIALAYVR
AKVSNVFPLV GGRKVEHLHD NIQALSIKLT PEQVEYLESV KPFDIGFPGN IFGPDPNVTG
QATGLLAASA PLAFVTEPKP IGLA
//
