ID   A1C8U4_ASPCL            Unreviewed;       996 AA.
AC   A1C8U4;
DT   23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT   23-JAN-2007, sequence version 1.
DT   24-JAN-2024, entry version 69.
DE   SubName: Full=NRPS-like enzyme, putative {ECO:0000313|EMBL:EAW13731.1};
GN   ORFNames=ACLA_044510 {ECO:0000313|EMBL:EAW13731.1};
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612 {ECO:0000313|EMBL:EAW13731.1, ECO:0000313|Proteomes:UP000006701};
RN   [1] {ECO:0000313|EMBL:EAW13731.1, ECO:0000313|Proteomes:UP000006701}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1
RC   {ECO:0000313|Proteomes:UP000006701};
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
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DR   EMBL; DS027046; EAW13731.1; -; Genomic_DNA.
DR   RefSeq; XP_001275157.1; XM_001275156.1.
DR   AlphaFoldDB; A1C8U4; -.
DR   STRING; 344612.A1C8U4; -.
DR   EnsemblFungi; EAW13731; EAW13731; ACLA_044510.
DR   GeneID; 4707282; -.
DR   KEGG; act:ACLA_044510; -.
DR   VEuPathDB; FungiDB:ACLA_044510; -.
DR   eggNOG; KOG1178; Eukaryota.
DR   HOGENOM; CLU_005562_2_0_1; -.
DR   OMA; CARVYHI; -.
DR   OrthoDB; 1211724at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR039261; FNR_nucleotide-bd.
DR   PANTHER; PTHR33927:SF5; ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01222)-RELATED; 1.
DR   PANTHER; PTHR33927; TRANSMEMBRANE PROTEIN; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006701};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        581..602
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        652..676
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        696..716
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        728..748
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        768..785
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          36..376
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
SQ   SEQUENCE   996 AA;  108815 MW;  62F05FE2E3996207 CRC64;
     MESSFTRHAD GILSREFGFG PQRAIPYPTA HHAFLHHALE DPGLLALHDL SEGAPREVSY
     GKLLQYAQFV TLQLQKQGVT AGSRVVLVTK RGLDMVAGIL GILMCGAQYI PLDGAVVPDQ
     TLEHALAQSE SRVVLCSRSF QHRISSNGQV SSILLLEDLV QEADRTGHSV EAGQVICQGD
     ENSGCYVIFT SGTTGTPKGV DVTHKNVTNV VCQSPGNLGI SRGSKVGQVL SISFDMGAWE
     ILGSLSNGAT LVLRGSDWHA ALRQIDTLIC TPSILNRYRP EDYPNIRCIA TAGEPCPQSL
     ADKWAANGVD FYNCCGPTEV TIINTMHRHH HGQPLTIGQP LPNNNVYILD DEKNPVKFGE
     IGTVWAGGMA VTRGYLGLYE KTVERYHYDP FVNDSHSQMF NTGDLARWLP DGNLEMLGRK
     DDQVKIKGFR VELDGVSASL AACPGVKRAA ALLVEGQLIG FLTPKSCNVE SIRTHLSKLL
     PYYATPSEWH AVEAFPLTPN GKIDKYALTQ QFHVVSETSS VSTSGALGEK KAVTQSSTDP
     STSVNLGSCE SLQKPVPLPV KKDGKLLRGL RYRIFIVYRR LFTLVWLANI AALLCIVLIP
     AIDRQWISIL AYINLTIAVL VRQDAVINIL YTACCSVPKS WPLAIRKRCA KIYHLGGVHS
     GAAIAATCWF AGSIGYNISR LVREGRLIAQ VSPATLTLSV IVLSLLFGMI ASAYPALRKA
     RHNTFESIHR FVGWTVLTII WVQTMLSIRD QTSVHQSLGR QVLISPKFWM LVVITLSIAS
     SWAFLKRVPV DAEVLSNHAV RLHFDYTMPV NGTFTRLSQR PLLEWHSFAT VPAPVAANGR
     PKGYSLVVSR AGDWTGRQIS NPPTHFWTRG IPTCGVMRIA TLFNKVVLVG TGSGIGPLLG
     HIQVPTCPFR LVWSTSNPEV TFGKDMMAAV YGADPHAVVH DTKKQGRPDL VQLTWDAVQS
     FGAEAVIVIS NEKLTKKVVY GMETRGVPAY GAIWDS
//