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Database: UniProt
Entry: A1CAU3
LinkDB: A1CAU3
Original site: A1CAU3 
ID   XKS1_ASPCL              Reviewed;         573 AA.
AC   A1CAU3;
DT   20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   16-APR-2014, entry version 37.
DE   RecName: Full=Probable D-xylulose kinase A;
DE            Short=Xylulokinase A;
DE            EC=2.7.1.17;
GN   Name=xkiA; ORFNames=ACLA_012890;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC
OS   3887 / NRRL 1).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P.,
RA   Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A.,
RA   Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A.,
RA   Galens K., Fraser-Liggett C.M., Haas B.J., Inman J.M., Kent R.,
RA   Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M.,
RA   Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R.,
RA   Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R.,
RA   Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Highly specific D-xylulose kinase which participates in
CC       the catabolism of xylose. Xylose is a major component of
CC       hemicelluloses such as xylan. Most fungi utilize D-xylose via
CC       three enzymatic reactions, xylose reductase (XR), xylitol
CC       dehydrogenase (XDH), and xylulokinase, to form xylulose 5-
CC       phosphate, which enters pentose phosphate pathway (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + D-xylulose = ADP + D-xylulose 5-
CC       phosphate.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- INDUCTION: By D-xylose, L-arabinose or L-arabitol.
CC   -!- SIMILARITY: Belongs to the FGGY kinase family.
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DR   EMBL; DS027049; EAW12861.1; -; Genomic_DNA.
DR   RefSeq; XP_001274287.1; XM_001274286.1.
DR   ProteinModelPortal; A1CAU3; -.
DR   STRING; 5057.CADACLAP00001387; -.
DR   EnsemblFungi; CADACLAT00001406; CADACLAP00001387; CADACLAG00001406.
DR   GeneID; 4706424; -.
DR   KEGG; act:ACLA_012890; -.
DR   eggNOG; COG1070; -.
DR   HOGENOM; HOG000174850; -.
DR   KO; K00854; -.
DR   OMA; GSYSPID; -.
DR   OrthoDB; EOG7CRTZN; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004856; F:xylulokinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0042732; P:D-xylose metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR018485; Carb_kinase_FGGY_C.
DR   InterPro; IPR018484; Carb_kinase_FGGY_N.
DR   Pfam; PF02782; FGGY_C; 1.
DR   Pfam; PF00370; FGGY_N; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Carbohydrate metabolism; Complete proteome; Cytoplasm;
KW   Kinase; Nucleotide-binding; Transferase; Xylose metabolism.
FT   CHAIN         1    573       Probable D-xylulose kinase A.
FT                                /FTId=PRO_0000393516.
FT   NP_BIND     471    472       ATP (By similarity).
FT   BINDING      97     97       Substrate (By similarity).
FT   BINDING     168    168       Substrate (By similarity).
FT   BINDING     284    284       Substrate (By similarity).
FT   BINDING     285    285       Substrate (By similarity).
FT   BINDING     366    366       ATP (By similarity).
FT   BINDING     475    475       ATP (By similarity).
SQ   SEQUENCE   573 AA;  63148 MW;  2248064E535829B4 CRC64;
     MASQGPLYIG FDLSTQQLKG LVVNSELKVV HISKFDFDAD SRGFSIKKGV LTNEAEHEVF
     APVALWLQAL DGVLDGLRKQ GLDFSRVRGI SGAGQQHGSV YWGENAEKLL GGLDAGKTLE
     EQLSGAFSHP FSPNWQDAST QKECDEFDAV LGGPEQLAEA TGSKAHHRFT GPQILRFQRK
     YPEVYKKTSR ISLVSSFLAS LLLGHIAPMD ISDVCGMNLW NIRKGAYDED LLKLCAGPFG
     MEDLKRKLGD VPEDGGLHLG KINKYYIDRY GFSSDCEILP STGDNPATIL ALPLRPSDAM
     VSLGTSTTFL MSTPSYKPDP ATHFFNHPTT PGLYMFMLCY KNGGLAREHV RDAINEKLGS
     PASQSWENFD RITLETPPLG QKSESDPMKL GLFFPRPEIV PNLRSGQWRF NYNPANETLT
     ESNDGWNNPS DEARAIVESQ MLSLRLRSRG LTQSPGAKIP PQPRRVYLVG GGSKNKAIAK
     VAGEILGGSD GVYKLDVGDN ACALGAAYKA VWAMERTPGQ TFEDLIGQRW REEEFIEKIA
     DGYQKGVFEK YGNAVEGFEK MEHQVLEQEA ARK
//
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