ID A1CCS9_ASPCL Unreviewed; 2556 AA.
AC A1CCS9;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 112.
DE SubName: Full=Polyketide synthase, putative {ECO:0000313|EMBL:EAW12336.1};
GN ORFNames=ACLA_063030 {ECO:0000313|EMBL:EAW12336.1};
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612 {ECO:0000313|EMBL:EAW12336.1, ECO:0000313|Proteomes:UP000006701};
RN [1] {ECO:0000313|EMBL:EAW12336.1, ECO:0000313|Proteomes:UP000006701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1
RC {ECO:0000313|Proteomes:UP000006701};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
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DR EMBL; DS027050; EAW12336.1; -; Genomic_DNA.
DR RefSeq; XP_001273762.1; XM_001273761.1.
DR STRING; 344612.A1CCS9; -.
DR EnsemblFungi; EAW12336; EAW12336; ACLA_063030.
DR GeneID; 4706058; -.
DR KEGG; act:ACLA_063030; -.
DR VEuPathDB; FungiDB:ACLA_063030; -.
DR eggNOG; KOG1202; Eukaryota.
DR HOGENOM; CLU_000022_31_0_1; -.
DR OMA; EYGIDSH; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775:SF29; ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000006701};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 36..463
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2475..2549
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2556 AA; 280401 MW; 76BAD2AD53D16DC2 CRC64;
MTANSFEGPT NPVPLPPSTP NTDMEDDIPN VVGDVSMPIA IIGMGFRGPA DATDVERLWR
MIVEGREAWS PIPESRWNSG AFYHPDHARH GTVNVQGGHF LAEDVSLFDA PFFNMTSDEA
AAMDPQQRLL LEVTYEGLEN AGLPLSKIMG SQTSCFVGSF NADYTDLLLR DPDAIPMYQC
TNAGQSRAMM SNRVSYFFDL KGPSVTVDTA CSGSLVALHL ACQTLRTGDA QMAIAAGVNV
ILSHEFMSTM TMMKFLSPDG RCHTFDEKAN GYARGEGIGC LILKPLKDAI RDKDTIRAVI
RGSGSNQDGR TPGITLPNGA SQEALIRHVY AMAGLEPHET DFVETHGTGT QAGDPIETGA
LTKVFCPKRS PEQPLRVGSI KTNVGHLEGT SGVAGVIKAV LMLENRTFLH NRNFSSLNPR
ILLDEWKLKI QLHPEAWEST RPRRVSVNSF GYGGSNAHVI VEDAEGYLLL HGLQALVGKQ
PTLYVEKPAE SKSNGTCAHP TQPIRTRLFI LSAFDEYSLT KQLENLESYL LARCKIADDR
YLNNLAYTLN RRRTTLMCRA AIIGDDAMSI SEALKANLKI RKATKKPVVG FVFTGQGAQW
CGMGRELLRA YPVFRQSMER IDAHITQIGS SFSVIDEILE NQDASRLNQP LHSQTICTAL
QIALVDLLGS WDIHPESVTG HSSGEIAAAY AIGALGLEDA MSAAYYRGIA ASRLSQNEEV
RGAMLAVGMP SDSIQPFLDS LKTGKAVVAC INSPTSVTVS GDVTAIGELE GVLREREIFH
RRLMVNVAYH SHHMELVGGE YLGLISNITP QAGDQVQQSR NRVVSFFSSV TGGEVQASDL
GSQYWTRNLL GQVKFVESVR ALCYGTNNTT RRTKRVGGMR KVGVDVLLEV GPHAALSGPI
RQILKEDSKL DAAGVQCISI LTRKSNSVTT ALEAAGTLAC LGYQVNFEAI NDPLQNIGDP
QVLIDLPCYV WNHNRSYWAE ARMSKAYRQR KNPRTDLLGV IDRMSCPFEP RWRNHLRVSE
LPWLRDHKIQ SNIVYPAAGY ISMAIEAVNQ HISDPEPHLN ISGFVLQDVS IQAALVIHEG
SSIEVMISLK ACQSAMSSAD QLFGFRVYSV SGENRWTEHC HGLIGAHTTS VYPDFEVPPP
QPSKTTDFSI IDMPDFYERL ATIGLEYGPC FTNLTHAHCV DNICLAEVII PDTAAVMPMS
FQYPFVVHPC VLDSIFHSIF VHMKNDDDPA IPIHIDELFV SRGVEREPGA KMHVNTEIER
RTRDGILASI TVSGRDDSLA IRVKGLQCKS LANGSLKNTG KSMDRIGYMV TWKPDPDLLS
NNELFSFLKE INARPENNCS DRSLLESCAS YFVHKAVEYL DKSGELQAHR RRQLDFMLSR
AEKNQLDMQF DTINPNLDYV SASGAEGRLL CALGEILPAT MRDQDPAPSP IDPSIWSAYW
DAVRSDPVYD KVARYLELIS HKNPMISILE VEGTIGEASL SFIERMMGIA GQAPGCSEYT
LTHPNLSIPE THSQRLSDMS QWLSLKRLDV EQTLETQGFD KYQYDVVLVP YGLYMARSKR
QALRNLRDLL KPQGQLIIVD PVSQSDGLVN SLIFAGFSAC WSGDQFGTSQ DDWKKAILEA
GFSDLKDFSN SSEGPLLMVT HPLQVHPRSK PDILIISEED ENGVDVLALQ KHLSSISSTI
EITNFAHAEP EERLCVLLSG LTSPLMTNLD KRGLEILQQI LLRATGVLWV TRGSTMNAMD
PNGAITTGFA RTARSESGIE RIVTLDLDGQ NPLSSDRAAD IIYTIVHECI IGGNDRVDME
YAERDGVLLI PRVVENKTFN ESFASSRESK TISYENFHQT SKPIKAMIPE TADADSFCFE
EDSSIAHLPT DYVRIQVHAT CVDKQNAQAL KGLGISSTEA SGCGISGVVE KVGQSVHGFL
PGDRVACFGF ETVASYHQDA ASAFQKLPSN MSVESAAALP VSYCTALYAT QYLARAGSAA
RILIYGAARA NRQAFAELCQ HIGANAFFLV RSEAEKNFII SEDIIDCDQI VDIRDLTYVP
SCGRAAKGKD FDVIISCVSP DNGTLRLLWK SIATSGTFIQ LCNHGDSEKR TWTIPRVSSD
VTFATFDIHQ LWRDKPVLLH KIWSEAMRLF NEGRIPVPKA SAVHRVSDMM EALTKLESDE
DMDLITLTAQ PGDVVKVVTP KLQGKLFQPD VSYMLVGGLG GIGRATALWM SDNGARTLIF
VNRSGLTTVA SQGTAKELEE NGTRVIVHAC DISDSTQVEN MLNELAHNAP PIRGVIQAAM
VLRDIHIEKM TIEDYHAALQ PKHAGTWNLH RYLPSELDWF IMLSSISGII GNATQAAYAA
GSTFLDAFAA YRNALGQPAV SLDLGAITDA GYLADNRELA SKMAQQGFHG TDTATLMSII
ETAIRTPFAA GASPQVITGL GHWKAGQSLS NFDAPLFAHF RRQFQERGGG EHAEELSGKL
RESLREIKSL EEASGIIYTA LSERIASHLS MLVESISPSN AITEYGIDSH MAVELRNWVA
KNMESTVPIL DILASSTLLD LAGKIASKSN LVNLEE
//
