ID A1CD09_ASPCL Unreviewed; 2421 AA.
AC A1CD09;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 24-JAN-2024, entry version 118.
DE SubName: Full=Polyketide synthase, putative {ECO:0000313|EMBL:EAW12416.1};
GN ORFNames=ACLA_063870 {ECO:0000313|EMBL:EAW12416.1};
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612 {ECO:0000313|EMBL:EAW12416.1, ECO:0000313|Proteomes:UP000006701};
RN [1] {ECO:0000313|EMBL:EAW12416.1, ECO:0000313|Proteomes:UP000006701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1
RC {ECO:0000313|Proteomes:UP000006701};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
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DR EMBL; DS027050; EAW12416.1; -; Genomic_DNA.
DR RefSeq; XP_001273842.1; XM_001273841.1.
DR STRING; 344612.A1CD09; -.
DR EnsemblFungi; EAW12416; EAW12416; ACLA_063870.
DR GeneID; 4705895; -.
DR KEGG; act:ACLA_063870; -.
DR VEuPathDB; FungiDB:ACLA_063870; -.
DR eggNOG; KOG1202; Eukaryota.
DR HOGENOM; CLU_000022_31_0_1; -.
DR OMA; STIHCER; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775:SF29; ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000006701};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 5..429
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2339..2416
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2421 AA; 265871 MW; 4A0ADE9ACEDA9CD5 CRC64;
MEQQTMPLAI IGMACQFAGD VSSPEKLWQL CADGNSAWKA IPESRFAQKE LYHPDNQKQG
TTNVEGGHFL EEDVSLFDAA FFNFSSEVAN TMDPQFRLQL ETVYEALENA GIPLDQIAGY
RTSVYAGAFF RDYHDSLMRD PATLTRFFMT GNGSAMASNR ISHFYDLRGP SMTVDTGCST
TLTTLHLACQ SLRNGESDVS IVAGSNILLN PDMFESMSSL GFLSPSGKSY AFDHRASGYG
RGEGVATLIV KPLTSALRDG DPIRAVIRET ALNQDGWTPT ITSPSQKAQE ELIRLFYQRA
GLDPLETSYV EAHGTGTPAG DPVEAAALSA ALNTNRSSQE PLLIGSVKSN IGHTETASGL
ASIIKVTMAL EKGYIPPSAN FEKPNKDIDM NGLNIEIPTL LRPWPQALRR ASVNNFGYGG
ANSHVIIESP AVLTQPSPAI VSESGSLQSR VFVLSAKEGA AVSRMASRMA EHLRGLTLDD
ESAYMRHLAF SLGQRRSNFP WKAAYLASTK KELIEKLEQG QVTPQQATEQ PRLGFVFTGQ
GAQWYAMGRE LIEAYPVFKD ALLEADQCLK SFGAKFSIIE ELSRDEASSK VNTAMLSLPL
CTAVQIALVK LLRSWNISPI GVTGHSSGEV AAAFTAGAID VRSAMAIVYM RGALTSSFQE
KIGSGRGGMV AVGLGKEAAE AYVAKLTTGK VVVACINSPE SVTVSGDITA IEELESQLVG
DGIFARKLKV EAAYHSHHMQ PFADEYSAAL QQILRDGKLD DDIIYSSPVS GTRTNGDEVS
RAEHWVQNML QPVLFLDSLT NLCLSSDLNQ QVDTILEVGP HSALAGPVRQ TMGLPAFEGK
RISYLSCLSR GENAVETMQS LAATLRSQGT RVDLSAVNFP INQEGLRVLH DLPSYPWNHA
HGYWAEPRLN KEHRLRRQKH HDLLGSPLIG GNALSPTWRH IIRLSDTPWL RAHKVQSNII
YPGTGYICMA IEAVHQLSQG QSHAMSSVSL KDVEILKILI VPETEAGVEV HLTLHESSDK
VLTGQLWQEF HIYSCDNSGK WSEHCKGLIA RNQGNEAYQR NASSDDNVYL RQLKPQELYR
TLQAKGIYHG KAFQNLVSIQ YNPGRSLCTL RVADTASSMP YGVEKPHVLH PTTLDSIFQA
VYSSLPTSAL KANTAMVPRA FKRMDVRTSM SSTPGHVFQA QSMLHRANPQ GMESSVVVSD
TTSKDPVLTV DGLYYQSLGI VPEADGEKND KQHHYTLQWA PDISFPTPRT LKAALQFAAD
FDEIGIIRDI REACFYFIRR ALANLAEDRV MKLNWHQQRL WAWMKVQIKL AQLNELGPIS
SEWAGMGGCT ELVLDALREQ DALGSRYRCA SYDFTDISSG FFEAASERFK EVGDVMEFKK
LNIEEDPSEQ GFESNSYDLV IASQVLHATK NINRTLANVR KLLRPGGKLL LVEITRDEID
LQLIFGTLPG WWLGEEAERQ SSPSLTIPEW QAAMKSTGFD GIDMELHDCE DEDFYAFSVL
MASAAIPDPA IYPQFTIVYK EMPPPKWLHK LITSLEKLTT FKPDVQQLGA FDAEGKTCLF
LGEMHEALLD EPGSAEFGFI QSLLIQAAGV LWVSRGSTIH CERPHNTLHT GLLRALRLEH
SSKRLVSLDI DPTTARWPVS AIATILDIAR RRFLLAQNPS HLDNEYAERG GIMCVPRVFE
TVDESSKTAR GIESPGTKTE LFHQSSQKLR LQVSTPGLLD TLGFVAEPMQ INPIPEESIE
VEPKAFGLNF RDVMVAMGQL SMDIMGFECS GVVTQVGSLA SQHGFKIGDR VCALMRGHWE
NRVCLHWTSV VAIPDGMTFE VAASIPMAFT TSYYALYETA RLQPGESVLI HAAAGGVGQA
AIILAQRVGA EVFVTAGSPE KREYLSRQFG IPEDHIFSSR DAEFASQLME ITAGKGVDVV
LNSLAGELLQ RTFNCVAPFG RFVEIGKRDL EQNKQLEMHA FTRHISFSSV DLIALGELKG
AVVSRIMNDI MRLIKDEGLR LIQPITTYPI SRIHEAFRIL QAGRHIGKVI VIPGPDDRVN
LLPSGWPLHL DSESTHLVIG GMGGVGRSIC EWLVQRGARN LIIMSRNAEQ QAQGSAYVNA
LRASGCTVVV ASCDISDKFE LKQTLDGCLQ SMPPLRGVIH SGMVLQDTVY ENMSLEDYAR
AVRPKVQGTW NLHQVLSDVD LVYFIMLSSL SGITGNVSQA NYSAGNTFQD AIARHRSARG
LPAVAIDLGM VREVGYVAET DGVANRLERM GFRAVDEEEV LHLIQEAILR PLRHATDSQI
LTGFNSHLST GDTNAFWAKD PILGGVLRAT GTKSTTRSNR VHDAMDLREQ LTNVPIPNDR
LVVLETAIVR KLAAMFFVEE AAIQVGESLA RYGVDSLVAV ELRNWLVVQL GIEVSIFDIM
QGASVKQLAS SLVAKWAAAA A
//