ID A1CKY6_ASPCL Unreviewed; 359 AA.
AC A1CKY6;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 24-JAN-2024, entry version 86.
DE SubName: Full=G protein complex alpha subunit GanA {ECO:0000313|EMBL:EAW09810.1};
GN ORFNames=ACLA_040260 {ECO:0000313|EMBL:EAW09810.1};
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612 {ECO:0000313|EMBL:EAW09810.1, ECO:0000313|Proteomes:UP000006701};
RN [1] {ECO:0000313|EMBL:EAW09810.1, ECO:0000313|Proteomes:UP000006701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1
RC {ECO:0000313|Proteomes:UP000006701};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- SIMILARITY: Belongs to the G-alpha family. G(q) subfamily.
CC {ECO:0000256|ARBA:ARBA00007976}.
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DR EMBL; DS027056; EAW09810.1; -; Genomic_DNA.
DR RefSeq; XP_001271236.1; XM_001271235.1.
DR AlphaFoldDB; A1CKY6; -.
DR STRING; 344612.A1CKY6; -.
DR EnsemblFungi; EAW09810; EAW09810; ACLA_040260.
DR GeneID; 4703537; -.
DR KEGG; act:ACLA_040260; -.
DR VEuPathDB; FungiDB:ACLA_040260; -.
DR eggNOG; KOG0082; Eukaryota.
DR HOGENOM; CLU_014184_6_0_1; -.
DR OMA; ANSHWFK; -.
DR OrthoDB; 2897309at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0090726; C:cortical dynamic polarity patch; IEA:EnsemblFungi.
DR GO; GO:0005834; C:heterotrimeric G-protein complex; IEA:InterPro.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:InterPro.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:EnsemblFungi.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0043409; P:negative regulation of MAPK cascade; IEA:EnsemblFungi.
DR GO; GO:0071507; P:pheromone response MAPK cascade; IEA:EnsemblFungi.
DR CDD; cd00066; G-alpha; 1.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR002975; Fungi_Gprotein_alpha.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF242; GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR PRINTS; PR01241; GPROTEINAFNG.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006701};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
SQ SEQUENCE 359 AA; 41434 MW; E5180B969E4F25BB CRC64;
MGCMGSKPVE ALDKEAVQQT ARIDKSLKND KKMMDRTIKI LLLGAGESGK STIIKQMRII
HDGGFPDDER RQTRAVIYSN LVIAFKVLLD IVSAENIEYE LETTKKLAEF IDELEPDVSS
DEAFSDYKVR DAMRDMWNDS GVQKAVYRGH EFALHDNLQY FFGSLDRLFQ PGWLPDNQDM
LQARLRTTGI TETLFELGQM NFRMMDVGGQ RSERKKWIHC FEGVQCLLFM VALSGYDQCL
VEDQNANQMH EAMMLFESLV NGEWFKRKPI ILFLNKIDLF RGKLEFSPVS KHFPDYNGSN
SDFDAAARYF ADRFRGINRI PDREIYIHYT NATDTTLLKA TMESVQDMII QKNLHTLIL
//
