ID A1CLU2_ASPCL Unreviewed; 528 AA.
AC A1CLU2;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Cytochrome P450 oxidoreductase, putative {ECO:0000313|EMBL:EAW09071.1};
GN ORFNames=ACLA_078190 {ECO:0000313|EMBL:EAW09071.1};
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612 {ECO:0000313|EMBL:EAW09071.1, ECO:0000313|Proteomes:UP000006701};
RN [1] {ECO:0000313|EMBL:EAW09071.1, ECO:0000313|Proteomes:UP000006701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1
RC {ECO:0000313|Proteomes:UP000006701};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971};
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|RuleBase:RU000461}.
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DR EMBL; DS027057; EAW09071.1; -; Genomic_DNA.
DR RefSeq; XP_001270497.1; XM_001270496.1.
DR AlphaFoldDB; A1CLU2; -.
DR EnsemblFungi; EAW09071; EAW09071; ACLA_078190.
DR GeneID; 4702680; -.
DR KEGG; act:ACLA_078190; -.
DR VEuPathDB; FungiDB:ACLA_078190; -.
DR eggNOG; KOG0156; Eukaryota.
DR HOGENOM; CLU_001570_2_1_1; -.
DR OMA; KNNPRTE; -.
DR OrthoDB; 2900138at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR GO; GO:0044283; P:small molecule biosynthetic process; IEA:UniProt.
DR CDD; cd11065; CYP64-like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR46300:SF1; P450, PUTATIVE (EUROFUNG)-RELATED; 1.
DR PANTHER; PTHR46300; P450, PUTATIVE (EUROFUNG)-RELATED-RELATED; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|RuleBase:RU000461}; Iron {ECO:0000256|RuleBase:RU000461};
KW Metal-binding {ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000006701};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..528
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002633691"
SQ SEQUENCE 528 AA; 59830 MW; D75ED20AE8F60676 CRC64;
MISIYILVGL VLLRLLYEYH RDRNLPPGPR RLPFIGNIHQ VPQSHPWRVF DAWSKRYGPL
MRAQFGRQTL ILIADTRIAR ALLDKRGAVY SDRPRMVMAG ENVTRGMHML LRPYDARYRL
HQRMEAPVLS PRASATYTPL QELESTQLLT DLLRSNNFTI HIQRYTASLV YGLAYGFRLP
TGAEPELLTL RRILHNFGHV ARVGTWLVDA IPLLNYLPAW LAPWKRSANA LFELEADLHR
RNMDTALHNK PWNWTKELAR SPHATPMSPL EFAYDLGNLT TAGYDTTASA MRVFVLAAVT
APAFIAAAQR ELDTIVGPDR LPSFADKENL PYIAAVVEET LRWRSIAPGG PPHATSAEDE
YMGYRIPKGA TVMPLHWSMS MDAGDFPDPL AFQPERWLAA PQQQQQQGGD GKGNEHERFT
SFFGWGRRMC AGRHIARNSL YILIARLLWA FEIRAAEGPD GRPKHVDDMA FDDGLVSSPE
PFEAVFVPRS EAVRRVVEGE WAGLEKDMEV VMGGIRERQR AIGLEVRV
//
