ID A1CQ78_ASPCL Unreviewed; 6262 AA.
AC A1CQ78;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=Nonribosomal peptide synthase Pes1 {ECO:0000313|EMBL:EAW07799.1};
GN ORFNames=ACLA_025160 {ECO:0000313|EMBL:EAW07799.1};
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612 {ECO:0000313|EMBL:EAW07799.1, ECO:0000313|Proteomes:UP000006701};
RN [1] {ECO:0000313|EMBL:EAW07799.1, ECO:0000313|Proteomes:UP000006701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1
RC {ECO:0000313|Proteomes:UP000006701};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- SIMILARITY: Belongs to the NRP synthetase family.
CC {ECO:0000256|ARBA:ARBA00029454}.
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DR EMBL; DS027059; EAW07799.1; -; Genomic_DNA.
DR RefSeq; XP_001269225.1; XM_001269224.1.
DR STRING; 344612.A1CQ78; -.
DR EnsemblFungi; EAW07799; EAW07799; ACLA_025160.
DR GeneID; 4701518; -.
DR KEGG; act:ACLA_025160; -.
DR VEuPathDB; FungiDB:ACLA_025160; -.
DR eggNOG; KOG1178; Eukaryota.
DR HOGENOM; CLU_000022_60_0_1; -.
DR OMA; YPCSRMQ; -.
DR OrthoDB; 2787863at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR CDD; cd05918; A_NRPS_SidN3_like; 4.
DR CDD; cd19542; CT_NRPS-like; 3.
DR CDD; cd19534; E_NRPS; 2.
DR CDD; cd19545; FUM14_C_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 4.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 5.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 6.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 9.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR PANTHER; PTHR45398; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR PANTHER; PTHR45398:SF1; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 4.
DR Pfam; PF00668; Condensation; 8.
DR Pfam; PF00550; PP-binding; 5.
DR SMART; SM00823; PKS_PP; 4.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 4.
DR SUPFAM; SSF47336; ACP-like; 5.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 15.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 5.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000006701}.
FT DOMAIN 801..877
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3378..3454
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4476..4552
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 5546..5622
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 6132..6213
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 5622..5652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6262 AA; 695378 MW; 2FB5E3BD758005BD CRC64;
MAHSAPCYLP KFGATHLGLQ RPLSMRLRIG ASQSAGLLAA WNEGHLNSLL QAAWALLLHR
YTGSEDICFG YHQIGGDGVQ NALQQPLDTA DPSIFKLSIN EDDTPKTFLD HVKTHSYFDS
DLDRSKPLIT TSNADLPFNT ILMIRICHDF KGTSSIPSLF PIALPEKVRN KHRTSKSPCK
NGPSNSCLQC RIRMQAKVLQ EEVGIFFEWW NNDMPTEQVK SIAGVFERIT AELLSAQDVS
LGSLDIFPEN DWSRVCKFNS VFPKKHERCI HDAIYEQTLL QPDHEAVCAW DGSLSYQQLD
DLSSKVAYYL QKRGVGPEVC VALCFEKSKW NIVAMVAVLK AGGAFVPMDP THPTARLQSL
VRGVQAQIML CSRNYAEKLQ TVAETLLPLD DEFVDTLPSP TTTVSSTVKS SNAAYVIFTS
GSTGEPKGTL LEHGAYFSSV MAHGPAFSID STTRILQFAA HTFDASLVDI LTGLMLGACV
CIPSEEARLT DIAGVINDMR IDFACLTPSF IGFLEPSAVP GLKTLVLAGE AMSPSHLATW
SHLTLVNGYG PTESSVTAAL NTKLSATSDC RDIGQQIGVR WWVVNPKNHD QLAPIGCPGE
LVLEGPTLAR CYVNNPQKTN DAFIYDPAWT KRDATGGSGR RFYKTGDLVR YSSVTGSLTY
IGRKDTQVKF HGQRIELGEI ENQLSTDVDV KHCVALLPKS GFSQGKLVAV LSLSAGLKDG
PDSDAVPLKL LENRVKAQYV KDIRERLSAR LPTYMVPSVW LCVETMPMLV SGKLDRKLTS
TWVSGMAQDP DMPATGPTEF RSINATEDQL ASIWSRVLNI SKDRISLKES FLSLGGDSIA
AITCVGQCKK QGIGLTVQEI LRSKSIRDLA TRVKEVQQPA AYHEKIEEPF DLSPIQKLHF
MVREEGQGYF NQSVLTRIDR RINDGELRRA VDAVVMRHSM LRSRLVGPGT GSPLQQRITE
DAAGSYRWRM HTTASQATVE KAVAESQLCI NAFVGPMFSV DFFYANNNTH NFLSLVGHHL
VVDIVSWRII LEDLEDYLND PQAFALQNSS LPFQTWCHLQ DEQCRSLLSE NELQVEDLPA
PDLAYWGMEA RPMTYGDVVC ETFDVDADST QSILLECHES LRTEPVEVFL AALLHTFGQT
FSDRALPVIY NEGHGREVWD SSIDISRTVG WFTTLYPIFV SDIVSNDPAR TVARVKDLRR
QVSDNGRQKF ASRMFTGQGQ EHCRHHCPLE MTFNYVGQHR DLQKQDGLFQ LTGHMAGETG
RGGGAADFGE ETPRFALLEI SALVVQGRLR FTFSFNRFMH RQEGIRDWIS RCQQLLSSLG
QQLQSSAPKP TLSDFPMLSL TYDELDKMVL EKLPRMDISS LDLVEDIYPC SRMQQGILIS
QSRDTSFYAV HDTFEVRGFR TKPDIGLLRL AWQKVVSHHS ILRTVFVQNL TSRDLFSQVV
LKEFESFPNL LTCSGDSDVL PTFESQQPMD YRQHCPAHRL TLCQTASGKL FCRLEISHAA
MDGMSISLIV RDLQLAYSGK LQEDRKPVFQ NYMKYLQTCS HNGGLEYWCD YLADIKPCHF
PVLNDGKLST KQLHTIRLNF ASLRELQTLC ESGGVTLSTA FSTAWGLTLR SFCSSDDVCF
SYMASLRDVA VEEIDAMIGP IINLLACRMK ITETASLRDV LDQVQNDYME SLPYRHTSLI
DIQHALKLSD TILFNSGVSY RKLPSQSLIN TDDIRLVEVG SIHDPAEFPV YVNIETTDDD
AQIDLHYWTD ALSDGQAQNV ASTFLKSLEN IIHCQDEEVR RLDALSEQNK QQIAIWNKHI
PKTVDRCVHE ILEETASSYP EATALSALDG SLTYSKLNEL SALLAFYLTK LGVGPGVLVP
MEFERSSWQI IAMLAVLRLG GICLPLTGIQ SDEIIEKLLV DHDVQVALAS PHKAQILEGT
ISYVVPVSKS LFDYLPRSGE TLTSSVKPTD GAYVVFTTGS VQGSKPVVLD HQTILTRAEA
FASALGLNET TKMLQFAPCT SDMFLQEVLS SLMCGGRVCI PADHSARNLS TSINTSHANT
VSITPSLASL IRPSDVPEVQ VLALHGERMT TQAKDLWSPK VRLHLWYGAA ECSSTSIHTS
DSPDETRNLG RSAGCTSWLV DPADHNLLVP IGCVGELVLE GPVLASGYLL EGEHSSENFI
EEPVWSLDSE HDGTIAETGA EIEHAPPIRR MFKTGDLARY ESDGSLVYMG RKGTGARIDN
WQVQKHLDSF LLPEYPSVLE LIRSDDEAEA ELLAVYIQFK TASSTNVDGQ ESSIGQSSPE
FHQLIAKLHT HLLSVLSAAQ VPNLYIPVPS MPLTSFGKLD RQLLRRETEN LPNSIRAEFD
LKSFHEFWRA ELAKPQATAQ LFPPAMSTSQ GVSATASLRK DAQISGKLNG VDLESAILTA
WALTISGYTQ SDDVVFGELL LEPELSTLDS AEKTPATIVP RRFQLDATST IAELLGRTQE
KRVAALPYQK AGLQGIKNVS ADTSRACGFN NLLSFAAIQN DKSNPLGLEY PLAIFCSIGQ
SELQLNAQYN EQVLSAPQVE RILAQFTSYI EYLNAGHGLQ EVIGEMALLQ SQASCLSSPE
TVYWKEYLAD AEPCHFPSLS AAKGEKRVET AQLTITDVAR LFAFCEMVGV TADALLQIVW
ALVLRCFTGS EEVCFGYYAE ASQTEDSNSA QVFPSRFLLK DASELREIAE DRENDLDQAI
VHPLSEDEVQ HELGLDVNSL FNTVFKFDKV QGLANADDSL FSKPHIVEKS NWILGINAKL
SDARAEIVFE YSTNVLSKAN IESLVDSFKH ILLDIVDHQQ IDRTIGAIDF FSEHACQQVQ
AWNATLPERP DMCAHEIIEQ HVLSRPTSPA ICSWDGDFTY EELDSLSTRL AQHLAGLGVR
PEVFVALCFE KSAWAVIAQV AVMKAGGAFA SVDPTHPEAR LQGLVEDLGA SIVLCSAKYV
DKASKIAQSA FVVSEETMTR LLESPSRTCV TRPDIHNPAY AIFTSGTTGK PKVTVIEHIC
LSVSSPAFTR TLGMTLDTRA LQFSSYTFDV SIMEIILVLM TGGCVCVPSE EERMNDLAGA
IKRLNANFIS CTPSMANTLD PADVPQLRTI VTGGEKMTPS HLERWSDRCV INAYGPSEST
VMATMSMKVD SAGVRLDDDC NSIGTAVCGR TWVVDPQNYH RLLPIGAVGE LVLEGSNVGR
GYLNNEQKTK EVFISEPAWA KSPGLRELFQ QKERMYRTGD LVRYKPDGSI CFISRKDTQI
KFNGQRIELE EIEQQCIACL PEGARVAVDV VDPETKAVAK SLSAFYSVGD IGNRSTVDDT
EMLVPMSEST REFAKKFQEA LTKVLPPSMM PKLFFPIRRL PYSTSGKLDR KKLRAAVETL
PKEQLKPYVS LSAGSRQVSD EGIEGILRGL WEEALGLASG SVSAEDSFFS LGGDSFSAMK
LVGAANSRGI SLTFAGIYED PIFMDMAKRC DTLREKPNKE TVPPFSLLPA STDRHQLLEE
VAEQCCVPRE TITDVYPCSP VQEGLLTLSV KQNGAYVAQP VFRLSERVDL DKFKAAWQRV
VDEMDILRTR VVHTESLNFL QAVLDKEEIA WTTAASLDEL MADSPDLPKH NGGALTDYAI
AGSQTSPARY FVWTIHHALY DGWSIPLVLK RLEEVYSNSS AGSKTLPYGL FIEYLLERNM
SDSDEYWKSQ LANLSCTPFP QSKNSLPDAV RVGNRHQSSM KISRAPGGVD LTVPELIRAA
WAVVVAAHTG SSDVCFGETL MGRNIDLPGV TDIAGPVLTT IPTRIQVENE LPITQYLESV
HHLTTTMLPH QHSGLQRIRK LNSDTASACE FQNLLVIQTG EGQLNENLWM AEPNQTSGDF
FTHPLVVECK VGDSEVTVTM HHDEMVLNSW QTEKLIGQFS FVLEQLLSIG KAETRKLNEL
EIFSPVDRNE VAKWNQRHPE AVEQCAHDII FERCSAHPDS PAICAWDGEV SYREMYDLAS
SFATYLVSRG IGPETLVPIC LDKSLWAVIT ILSIFIAGGA YVPLDPAHPT SRHEEILAEV
DARVVLCSPQ YHNRYSGIVK TIIPVSKETV KAYSALSGNA KRSNHVTPSN MAYAIFTSGS
TGRAKGIIID HRALASSVMA FGPLVGLTET SRAFQFASLT FDAAVMEVLA TLMHGGCICI
PSEDERLNDV AGAIRRMNVT WTFLTPSIAS IIEPSSVPSL EVLVCGGEKL SREVVTKWAH
RVRLINGYGP TETTIFAVLN TEVSSNRDAS CIGFGIPCTL TWIVDPDNHD RLAPLGAIGE
LALEGPALAR EYLKNPQKTA EAFVDEPAWI KNFQSSLPSP RRIYKTGDLV RYNPDGSVEY
ISRKDHQVKL HGQRMELGEI EHRLYEDDHV RHAVVILPKA GPLQQRLVTV LSLNSLNSNA
SIITDNTCEL ISPEDLAKTA YSELIAIQKN LEAQLPIYMV PQTWALIKKL PMLVSGKLDR
KKITYWVEHI DDATYERIMQ DYDNIKRGNV EESVKDDKET SVSILRDIYA QVLNISANKV
DPNRSFVSLG GDSITGMAVI SRARKQGINL TLHKILQSKS IGELTRGIET KTSAVQLEEK
SGENFPLSPI QGLYFQAART FKETGRFNQS MTVRITRKVE PKIIRNALKA ILTQHSMFRA
KFSRSASGKW QQRITSNIDA SYRFGVHSVS NPREMLTKIG ETQSSLDIQN GPIFAADLFE
VATGEQVLFL VANHLCVDMV SWRIVLQDMQ EFIESGSLPS EKPLSFQAWC DLQFQKSKSE
ADVVQPPFAI EPSNIGYWGM DSLPNLYGQI KMESFVLDEK TTSFILGGCH ETLRTETIDI
LLAAVVQSFR RVFTDRNMPT IYNEGHGRES WDSSIDLSRT VGWFTTMCPL QVDECSDFIE
TAKRMKDVRR KMVDNGRSFF AHSLLHSSKA NSTNFPAPLE IVFNYLGRLQ QLERDDSLFQ
HYGQAFDEET FNIAGDMGPD TPRFALLEIS ALIIKDKLQV SFTYNRQMQR EKQIRSWISE
CRNVLERDVL RFKDAVPEPT LSDFPLLPIT YDGLRRFMGS TLPRAGIDSW YTVEDIYPCS
SVQEGILLSQ LRDPNAYMFH VVFEVCHPNK GRQVNPASLK SAWSAVISRH PILRTRFIDS
NHAGGSFDQL VLRKVDDEAI MVESNDSNAL GRLDAIKLSD VNAGQRSKSL HQLTICQTQS
GRVLVKIEMN HAIIDGGSVD LILRDLAMAY NDQLPEGSGP LFSDYIKFIR GKSQDQALYH
WRQYLSNARP CHLTFPAGAA GERQLGSVMV QFNRYAELQQ FCEKNSVTLA NLTLSAWAIV
LQAITGSDDV CFGYPSAGRD APVPGIQDAV GIFLNMLCCR VRFSRGQTLL DLSKTVQSDY
IKKLPYQDCS LASIQHELAQ KERMLFNTTI SIQNHHAASK DSGSDMLSYN VQKAHDPTEY
PVTVNVETAK GHEGILLRYW TDAVPENKAQ DLADAIASIF TSFVDRPSQL VSDLELLGRS
TTGQFSGAGQ YIDNKTLQEL IDRRVTEIIT QMLRDGSLTI PTPQPEKSHI QETVPYSPLE
VPIQARRMPR ERDMSDSTAT LTEDHTRVSD LEKRLWKLWC SALHLSSETI KHRESFFKLG
GDSITAMKMV SAAREDGLTL TVADVFSNPV FEDMLAIISA ANSSPASEPE SHTDSEIEKP
AESVPIQQEQ TPPPPEFSFL KAVDLNDNAL QSGICPKIGV FKGGIADVLP VTDFQAMSIT
ATLFRSRWMV NYFFLDGQGT VDLKRLRESL LRVVDAFDIL RTVFVCFNGQ FYQVVLRKIR
PNIFVHETEK SLDEYTDYLQ QQDREQEARQ GEQYVQFYVL KKKDSNHHRI LIRMSHAQFD
GVCLPSIMSA IKLGYEGSPL PPAPSFANYM RMLSGAITPD HYQHWTNLLR GSSMTQVLRR
SETNTFQHIG AFTEQRKMLE IQPSVLDNIT IATVMQAAWA VTLAKLSAQP DVVFGLTISG
RNTSIPGIEN TVGPCLNVIP VRVKFGEKWT GLDLFRYLQD QQIANMPFEA LGFREIIRRC
TDWPDSTYFT TSVFHQNVEY EGQMQLDNTT YRMGGVGVVD NFTDMTLFSK SISDGKLGVS
LGYSLKGPIQ PKFATKVLNM VCDTVQSLVS NARVVLPSPS MLSSLPCQAV PDVPRMSDEM
FLSSHLKTRS ISEILVYSDV LTKAWQQVLP CKNAETPQSA FQLDSSFFDL GGDVFDVAQV
VWLLEQDGLQ VHLEDLLEHP TFLGQMAVLT LHNSPKNDSM EEIVPVDGLT LPMAKTGNSS
SFGKALTLAK RMAKWSPLSA RG
//
