ID A1CT25_ASPCL Unreviewed; 311 AA.
AC A1CT25;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=C-3 sterol dehydrogenase, putative {ECO:0000313|EMBL:EAW06462.1};
GN ORFNames=ACLA_081520 {ECO:0000313|EMBL:EAW06462.1};
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612 {ECO:0000313|EMBL:EAW06462.1, ECO:0000313|Proteomes:UP000006701};
RN [1] {ECO:0000313|EMBL:EAW06462.1, ECO:0000313|Proteomes:UP000006701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1
RC {ECO:0000313|Proteomes:UP000006701};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. {ECO:0000256|ARBA:ARBA00007637}.
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DR EMBL; DS027060; EAW06462.1; -; Genomic_DNA.
DR RefSeq; XP_001267888.1; XM_001267887.1.
DR AlphaFoldDB; A1CT25; -.
DR STRING; 344612.A1CT25; -.
DR EnsemblFungi; EAW06462; EAW06462; ACLA_081520.
DR GeneID; 4700207; -.
DR KEGG; act:ACLA_081520; -.
DR VEuPathDB; FungiDB:ACLA_081520; -.
DR eggNOG; KOG1430; Eukaryota.
DR HOGENOM; CLU_007383_6_8_1; -.
DR OMA; GDHFKRG; -.
DR OrthoDB; 1133at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43000:SF7; DTDP-D-GLUCOSE 4,6-DEHYDRATASE; 1.
DR PANTHER; PTHR43000; DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006701}.
FT DOMAIN 11..168
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
FT DOMAIN 195..270
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 311 AA; 34214 MW; A166F06E57AF0FF3 CRC64;
MAEVRPALKS VLINGGTGFV GSALTRVLSE KHPECVITVI DLHQPGPVHL IPDDVLFIRV
DITNPAEVSK AMQQVQPDIV IHTAGVIPAV SERFSRRLED DLRKIIVDGT KNMLKAAKST
KVKGFVYTGT CRIITNDMDR SHPNIDEPWP IPHSSLIYGE SKVASTSHAH GCLFPSTFRA
LRTWRLSASA CDTCNALQKK ETPFVVGSGL NLWDITYVIN VADAHVLAAK NLMTSKTAAG
EAFFIQSNEP ITFRDFCLAI WAHFGHVSSF EIHVPRALAY LVRLMSEYWT WMSGTAATLS
RGSVKDACST R
//
