ID A1CX62_NEOFI Unreviewed; 665 AA.
AC A1CX62;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 24-JAN-2024, entry version 92.
DE SubName: Full=GTPase activating protein for Arf, putative {ECO:0000313|EMBL:EAW25214.1};
GN ORFNames=NFIA_107050 {ECO:0000313|EMBL:EAW25214.1};
OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=331117 {ECO:0000313|EMBL:EAW25214.1, ECO:0000313|Proteomes:UP000006702};
RN [1] {ECO:0000313|Proteomes:UP000006702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 /
RC NRRL 181 / WB 181 {ECO:0000313|Proteomes:UP000006702};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS027685; EAW25214.1; -; Genomic_DNA.
DR RefSeq; XP_001267111.1; XM_001267110.1.
DR AlphaFoldDB; A1CX62; -.
DR EnsemblFungi; EAW25214; EAW25214; NFIA_107050.
DR GeneID; 4593798; -.
DR KEGG; nfi:NFIA_107050; -.
DR VEuPathDB; FungiDB:NFIA_107050; -.
DR eggNOG; KOG0703; Eukaryota.
DR HOGENOM; CLU_017628_0_0_1; -.
DR OMA; FQNLQVS; -.
DR OrthoDB; 1022106at2759; -.
DR Proteomes; UP000006702; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR CDD; cd08204; ArfGap; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR45705:SF7; ACTIVATING PROTEIN FOR ARF, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G09120)-RELATED; 1.
DR PANTHER; PTHR45705; FI20236P1; 1.
DR Pfam; PF01412; ArfGap; 1.
DR SMART; SM00105; ArfGap; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50115; ARFGAP; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Reference proteome {ECO:0000313|Proteomes:UP000006702};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 15..129
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REGION 125..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 263..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 431..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 522..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..601
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 624..655
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 665 AA; 71781 MW; 843ADE529C5D1443 CRC64;
MPSIVSKRQQ QRNEKALQDL IRSVPGNDRC ADCGAFNPAL HRKLGTHISK VKSLTMDTWT
AEQVDVSDRF NNVRRRELIV YGAQNMKSHG NTLMNKIFNP KNVKPPVPKD IDEADSSMER
YIRQKYQYRS LEDGKPKPPS RHDSSYDISP EGSPPPLPPK SGRFPGPGLR SASSTSNLQR
SSNRPFATSP RSERPDSPPP RSVSTSGSQG FGLSVRDTSD ASFESKLAQL RDLGFTNERR
NAAALKGLDG NLKMTIETLQ RLGEGPASLG RPSAAGNPTN NSTRGDSSAN PFDLLDSKPS
PQTSSAYNPF DMPTSQAQQQ LAPAPAPVQS LEGSFQHLQV SQPLFPHQTG GYPGRQASLP
QPLYQHPLTP PITSTQSQGT YISSPQAFDG SQNPFFQSST QPQAPFTSTP LTESPGVAQT
NPFFSQFGAA ANSMQSQPQS VSGGALPNPP QHANTMPALS STSPFSQGSY QQQQQPQQQQ
FLQNQPHLQG QGFASQNPFQ SMAAPNTPQN AVYQHQYQPQ LQAGMQQPTQ YMAPQPTGRV
DKGSILSLYN TSSAQASGMQ QPSQMQAPTG MSLNQAPPNQ PMPSISEHQN NGPQASAAPQ
LAGSRNPFMG GQGGPGAGMD LTPKASQLNG NFPRTHMSQQ SVDINGFQSG RHSPDAFANL
SARYR
//
