ID A1D416_NEOFI Unreviewed; 683 AA.
AC A1D416;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 24-JAN-2024, entry version 69.
DE RecName: Full=Cytosolic neutral trehalase {ECO:0000256|ARBA:ARBA00024422};
DE EC=3.2.1.28 {ECO:0000256|ARBA:ARBA00012757};
DE AltName: Full=Alpha,alpha-trehalase {ECO:0000256|ARBA:ARBA00030473};
GN ORFNames=NFIA_018600 {ECO:0000313|EMBL:EAW23159.1};
OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=331117 {ECO:0000313|EMBL:EAW23159.1, ECO:0000313|Proteomes:UP000006702};
RN [1] {ECO:0000313|Proteomes:UP000006702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 /
RC NRRL 181 / WB 181 {ECO:0000313|Proteomes:UP000006702};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 37 family.
CC {ECO:0000256|ARBA:ARBA00005615}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS027688; EAW23159.1; -; Genomic_DNA.
DR RefSeq; XP_001265056.1; XM_001265055.1.
DR AlphaFoldDB; A1D416; -.
DR EnsemblFungi; EAW23159; EAW23159; NFIA_018600.
DR GeneID; 4591725; -.
DR KEGG; nfi:NFIA_018600; -.
DR VEuPathDB; FungiDB:NFIA_018600; -.
DR eggNOG; ENOG502QWE4; Eukaryota.
DR HOGENOM; CLU_007933_3_0_1; -.
DR OMA; LQIMYNT; -.
DR OrthoDB; 67137at2759; -.
DR Proteomes; UP000006702; Unassembled WGS sequence.
DR GO; GO:0004555; F:alpha,alpha-trehalase activity; IEA:UniProtKB-EC.
DR GO; GO:0005991; P:trehalose metabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR Gene3D; 2.60.420.10; Maltose phosphorylase, domain 3; 1.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR035398; Bac_rhamnosid_C.
DR InterPro; IPR001661; Glyco_hydro_37.
DR PANTHER; PTHR34987:SF5; ALPHA-RHAMNOSIDASE; 1.
DR PANTHER; PTHR34987; C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED; 1.
DR Pfam; PF17390; Bac_rhamnosid_C; 1.
DR Pfam; PF01204; Trehalase; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006702};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..683
FT /note="Cytosolic neutral trehalase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002634040"
FT DOMAIN 588..641
FT /note="Alpha-L-rhamnosidase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF17390"
SQ SEQUENCE 683 AA; 74748 MW; 5E7990C68CA7B959 CRC64;
MTRFHFLNVV LSLLALLPVV LAQTCWRNTT CSGPEGSAFE GPWEKGIYAP SSRTVRPKKV
LSITDLSLNS AYAQVMPATL HGNGSLVIFD FGIEVGGIVT LNYTSSGSGA LGVAFTEAKN
WIGEWSDSSN GAFKGPDGAL YANFAQAGKG SYTMPGEALR GGFRYMTVFL VTNKSAKVQI
EDVSLEIGFQ PTWSNLRAYQ GYFHSNDELL NRIWYSGAYT LQTNSVPVNT GRQVPMLHNG
WANNATLGPG DTIIVDGAKR DRAVWPGDMG IAVPSAFVST GDLESVKNAL QIMYNTQNTT
TGAFDESGPP LSQKNSDTYH MWTMIGTYNY VLFSNDTDFL STNWQKYQAA MDFIYGKVDE
MSGLLIVTGT RDWARWQQGY NNSEAQMILY HTLKTGAQLA AWAESTHSLA HTWDTRAENL
KTAINQYCWD DAYGAFKDNA TATSLHPQDA NSMALLFGIV NETRAASISE RLTDNWTPIG
AVAPELPENI SPFISSFEIQ GHFAAGQPTR ALELIRRSWG WYLNNPNGTE STVIEGYLAN
GTFGYRSSRG YSYDASYVSH AHGWSAGPTS ALTNYIVGLS ITSRGGLTWK IAPQFGDLKS
AEAGFTTMLG KYKASWKRNS RGYTLQFSVP QGTRGTLTLP FVTSPKKPSI KIDGHDIKRG
LVYENETVTI TMTGGGSHYV VVR
//
