ID A1DF85_NEOFI Unreviewed; 1847 AA.
AC A1DF85;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=CNH domain protein {ECO:0000313|EMBL:EAW18042.1};
GN ORFNames=NFIA_079840 {ECO:0000313|EMBL:EAW18042.1};
OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=331117 {ECO:0000313|EMBL:EAW18042.1, ECO:0000313|Proteomes:UP000006702};
RN [1] {ECO:0000313|Proteomes:UP000006702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 /
RC NRRL 181 / WB 181 {ECO:0000313|Proteomes:UP000006702};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
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DR EMBL; DS027696; EAW18042.1; -; Genomic_DNA.
DR RefSeq; XP_001259939.1; XM_001259938.1.
DR STRING; 331117.A1DF85; -.
DR EnsemblFungi; EAW18042; EAW18042; NFIA_079840.
DR GeneID; 4586495; -.
DR KEGG; nfi:NFIA_079840; -.
DR VEuPathDB; FungiDB:NFIA_079840; -.
DR eggNOG; KOG4305; Eukaryota.
DR HOGENOM; CLU_001083_0_0_1; -.
DR OMA; DMFYHPG; -.
DR OrthoDB; 2734900at2759; -.
DR Proteomes; UP000006702; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041675; PH_5.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF1; RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF15405; PH_5; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Reference proteome {ECO:0000313|Proteomes:UP000006702};
KW Transferase {ECO:0000256|ARBA:ARBA00022676}.
FT DOMAIN 1012..1204
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1475..1787
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 1..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 547..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1316..1353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..462
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 742..784
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1339..1353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1847 AA; 204629 MW; 5E161BC7E6780605 CRC64;
MAHYQNGQTP YYGQSNNPTP SSTQPPSSSR YDHYNTQQQS ANSQLRRMPS YNVGDDAGLS
GGGSGAQHTR TANGSTRYTG QASNYGTEDG QGSYSLANSG HDDISGPRYA HIPSGGSPHV
TRDRASSQSN YSYQYSSIAS PTQSAYNPQQ YALPPTPLQQ QLGYNPLAYN SSSSNAYTAG
ATAAHQPYNP AAYQSASLAG YGSPTVQRQP SIASLYAQPP QTSQTYSSQQ SLPPPPPPRG
PDHPYGSRAS APYRTDSPAT QYGFSSQSSA SLAYNVAPPM GPTTPYPSTS SLTSTTIAST
FTRSHAHSSQ FPLYTAQSPH HSDAAMAPYP DELPPEPPAH STPAEDLYGK RLSFSRPGSG
RSLPTPPIQQ AQSQTSPRRT DTLTRHPQSR PLPGPPVDAD SDSPPLDDLN GVGGRDPRSD
QPVGYDHLMR EVETAVIDGR MSRETRYDTR PLRVDAQTSR HEEYDPSPPV TATSSMRLSP
DERHTHTNGT LATGTGQYVN YDAYSDDSDA EAAAGLAMLQ MADEEDRIQA EREQARTRRE
TNASIISAYG SHSSARAPSP RRESRQDELH STTNATYSGN HYERYHYDAD MDEHADETRN
EGVDQATRLA PSGSIRSSNV SADDRGEYSD DYDYYPIPDD QVHQYYDYIS AARVDAAGTG
GLSEPGAYER RMSFDYGDEA DAYPDDVHHS GSEGSDTGGM PGDLFFHPGM RPLPPAPVEP
ANNADLMPHL MPAGTYRPQE SGEYPEETQY TSPQYPVSAD SFASTVSTPT SQVPRSTSLS
SHPIGPRTDP PIRSKTDADR AKYKQQLDLL RQQQHGAFKL DAAQEAPAIP LDLPTIPAGR
RKKFNPSKLS SEQFRKCVEP WALSAVLAWI RDLCEEETDL RKSAIVDAIV ALFTHKVPTM
NIADAETLAA RVVENMLEQE ALVKEEEWVK FGSGTLSGVL FQITGTGCYS PLLHEQETEI
LGRCYSHHCM RTLKKVNLKA HKMAPQKKVE DWVTFYKVPK EVWEAYPKKE VDRQNNLHEI
VTTEDAFIGQ LDVLRELYRD QLANMQPAII PPKRLPKFLN DVFGKVDAVK KVNEEYLLAQ
LKYRQKEQGP FIVGFSDIFR EWIRKAKMVY IDYAATFPYA NYLVRKEMER NAHFRQFLNQ
AREHKMSNRL SWDTYLKAPI TRIQRYTLLL STVHKNMVKD CEEKTNLAQA IDEIKVVALD
CDNKVGETSK KVDLMELSAK LQLRPEMKKE VELNLQHLGR EIIYRGDLQR PGTRTRFLVD
THAILFDHYL VLAKLSTTRD PTRGIKYESY DVSKLPIPMD LLVLESTNDD PVVKSSVRGV
STVTPPQATT RGAGAAPLIH SNSGNSGNST SSSGKTLVAA TVLESSKDDK ILYPFKVKHL
GKNGTFTLYA FSAQNRQEWC EKIMEAKTRH AAALFAQNAE PFRLRVLADT AFASSDHSGI
SKRTVTIKGT PLDRAIREVE ERYGGSKSRP VPVCRTSVHC ATVFQQPPGR MMCAVGTDYG
VYISEYNDPR GWVRAIPIIR VSQIAVFEEF NLFLLIADKS LIAYHLDVVC PASGVSSQTT
KDSARRAPQK LSGNREVGFF AAGHMKDRTL VMYKKRDGLS STFKVLEPVL QKSTTSKSRL
FHSRRSQTEF FREYDEFYIP AESYGINMFH SSLAISTQRG IEILTLDKKQ TWSVPDFRSE
APEAQAQLSS IAHRISNLRP LGMFRLSDSE FLVAYTDCAV YVNKHGDVSR SVIMEFVGRA
HSACLYGKFL ILFNEDFVEV RNAMNGRLRQ VIPGHNVVCL DDGSTLPGSG ANTVPTNSGT
SINLASGLSN GVAMASNGRT VKICMQHPEY ERSQLVLELI ENEGQKE
//
