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Database: UniProt
Entry: A1DS18_CAVPO
LinkDB: A1DS18_CAVPO
Original site: A1DS18_CAVPO 
ID   A1DS18_CAVPO            Unreviewed;       165 AA.
AC   A1DS18;
DT   23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT   23-JAN-2007, sequence version 1.
DT   30-AUG-2017, entry version 71.
DE   SubName: Full=Nav1.2 sodium channel protein {ECO:0000313|EMBL:ABK96793.1};
DE   SubName: Full=Sodium voltage-gated channel alpha subunit 2 {ECO:0000313|Ensembl:ENSCPOP00000019487};
DE   Flags: Fragment;
GN   Name=SCN2A {ECO:0000313|Ensembl:ENSCPOP00000019487};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Caviidae; Cavia.
OX   NCBI_TaxID=10141;
RN   [1] {ECO:0000313|EMBL:ABK96793.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Ciocca D., Clerc N., Castets F.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ABK96793.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Sage D., Salin P., Alcaraz G., Castets F., Giraud P., Mazet B.,
RA   Crest M., Clerc N.;
RT   "Nav1.7 and Nav1.3 are the only TTX-sensitive sodium channels
RT   expressed in the adult guinea pig enteric nervous system.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSCPOP00000019487, ECO:0000313|Proteomes:UP000005447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000019487,
RC   ECO:0000313|Proteomes:UP000005447};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [4] {ECO:0000313|Ensembl:ENSCPOP00000019487}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000019487};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AAKN02005772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02005773; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02005774; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02005775; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; EF054796; ABK96793.1; -; mRNA.
DR   Ensembl; ENSCPOT00000024159; ENSCPOP00000019487; ENSCPOG00000002692.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   HOGENOM; HOG000231755; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000002692; -.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   Pfam; PF00520; Ion_trans; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Ion channel {ECO:0000313|EMBL:ABK96793.1};
KW   Ion transport {ECO:0000313|EMBL:ABK96793.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transport {ECO:0000313|EMBL:ABK96793.1}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    165       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5010820055.
FT   DOMAIN        1    151       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:ABK96793.1}.
FT   NON_TER     165    165       {ECO:0000313|EMBL:ABK96793.1}.
SQ   SEQUENCE   165 AA;  19210 MW;  490D300C084465BE CRC64;
     FDISIMILIC LNMVTMMVET DDQSQEMTNI LYWINLVFIV LFTGECVLKL ISLRYYYFTI
     GWNIFDFVVV ILSIVGMFLA ELIEKYFVSP TLFRVIRLAR IGRILRLIKG AKGIRTLLFA
     LMMSLPALFN IGLLLFLVMF IYAIFGMSNF AYVKREVGID DMFNF
//
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