ID A1IMF0_CHICK Unreviewed; 224 AA.
AC A1IMF0; A0A1L1RQZ0; F1NIT5;
DT 06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2007, sequence version 1.
DT 24-JAN-2024, entry version 115.
DE RecName: Full=Ubiquitin carboxyl-terminal hydrolase {ECO:0000256|RuleBase:RU361215};
DE EC=3.4.19.12 {ECO:0000256|RuleBase:RU361215};
GN Name=UCH-L1 {ECO:0000313|EMBL:CAF21961.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:CAF21961.1};
RN [1] {ECO:0000313|EMBL:CAF21961.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=White leghorn {ECO:0000313|EMBL:CAF21961.1};
RC TISSUE=Neural retina {ECO:0000313|EMBL:CAF21961.1};
RA Muhleisen T.W.;
RT "Expression of deubiquitinating enzymes in the embryonic chicken retina.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707,
CC ECO:0000256|RuleBase:RU361215};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004628}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004628}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the peptidase C12 family.
CC {ECO:0000256|ARBA:ARBA00009326, ECO:0000256|RuleBase:RU361215}.
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DR EMBL; AJ621938; CAF21961.1; -; mRNA.
DR RefSeq; NP_001073681.1; NM_001080212.1.
DR AlphaFoldDB; A1IMF0; -.
DR SMR; A1IMF0; -.
DR STRING; 9031.ENSGALP00000061212; -.
DR MEROPS; C12.001; -.
DR PaxDb; 9031-ENSGALP00000023022; -.
DR GeneID; 770302; -.
DR KEGG; gga:770302; -.
DR CTD; 7345; -.
DR VEuPathDB; HostDB:geneid_770302; -.
DR eggNOG; KOG1415; Eukaryota.
DR HOGENOM; CLU_054406_2_0_1; -.
DR InParanoid; A1IMF0; -.
DR OMA; TCFVQAP; -.
DR Reactome; R-GGA-5689603; UCH proteinases.
DR Bgee; ENSGALG00000014261; Expressed in spermatid and 12 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd09616; Peptidase_C12_UCH_L1_L3; 1.
DR Gene3D; 3.40.532.10; Peptidase C12, ubiquitin carboxyl-terminal hydrolase; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001578; Peptidase_C12_UCH.
DR InterPro; IPR036959; Peptidase_C12_UCH_sf.
DR PANTHER; PTHR10589; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR10589:SF19; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L1; 1.
DR Pfam; PF01088; Peptidase_C12; 1.
DR PRINTS; PR00707; UBCTHYDRLASE.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00140; UCH_1; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361215};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Prenylation {ECO:0000256|ARBA:ARBA00023289};
KW Protease {ECO:0000256|RuleBase:RU361215};
KW Thiol protease {ECO:0000256|RuleBase:RU361215};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|RuleBase:RU361215}.
FT DOMAIN 84..100
FT /note="Ubiquitin carboxyl-terminal hydrolase family 1
FT cysteine active-site"
FT /evidence="ECO:0000259|PROSITE:PS00140"
SQ SEQUENCE 224 AA; 25111 MW; 3856F6A4BB177F63 CRC64;
MAWQPMEINP EMLNKVLSRL GVSPGWRFVD VLGFEEEALG AVPSPACALL LLFPLTEQHE
NFRKQQTEKI KDQEISSKVY FLKQTVSNSC GTIGLIHAVA NNKDKVKLDE GSALKKFLDE
TADLSPEERA KRFANNKAIQ EVHNSVAQEG QCRVEDNSVN FHFILFANVD GHLYELDGRL
PFPVNHGTSS DDLLLKDSAK ICRQFTEREK GEVRFSAVAF CKSA
//